FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210644602> ?p ?o ?g. }

• W4210644602 endingPage "2012" @default.
• W4210644602 startingPage "1999" @default.
• W4210644602 abstract "Macrophages are white blood cells with diverse functions contributing to a healthy immune response as well as the pathogenesis of cancer, osteoarthritis, atherosclerosis, and obesity. Due to their pleiotropic and dynamic nature, tools for imaging and tracking these cells at scales spanning the whole body down to microns could help to understand their role in disease states. Here we report fluorescent and radioisotopic quantum dots (QDs) for multimodal imaging of macrophage cells in vivo, ex vivo, and in situ. Macrophage specificity is imparted by click-conjugation to dextran, a biocompatible polysaccharide that natively targets these cell types. The emission spectral band of the crystalline semiconductor core was tuned to the near-infrared for optical imaging deep in tissue, and probes were covalently conjugated to radioactive iodine for nuclear imaging. The performance of these probes was compared with all-organic dextran probe analogues in terms of their capacity to target macrophages in visceral adipose tissue using in vivo positron emission tomography/computed tomography (PET/CT) imaging, in vivo fluorescence imaging, ex vivo fluorescence, post-mortem isotopic analyses, and optical microscopy. All probe classes exhibited equivalent physicochemical characteristics in aqueous solution and similar in vivo targeting specificity. However, dextran-mimetic QDs provided enhanced signal-to-noise ratio for improved optical quantification, long-term photostability, and resistance to chemical fixation. In addition, the vascular circulation time for the QD-based probes was extended 9-fold compared with dextran, likely due to differences in conformational flexibility. The enhanced photophysical and photochemical properties of dextran-mimetic QDs may accelerate applications in macrophage targeting, tracking, and imaging across broad resolution scales, particularly advancing capabilities in single-cell and single-molecule imaging and quantification." @default.
• W4210644602 created "2022-02-08" @default.
• W4210644602 creator A5003195041 @default.
• W4210644602 creator A5004490629 @default.
• W4210644602 creator A5014609535 @default.
• W4210644602 creator A5020694281 @default.
• W4210644602 creator A5022084087 @default.
• W4210644602 creator A5025892124 @default.
• W4210644602 creator A5034220753 @default.
• W4210644602 creator A5036358235 @default.
• W4210644602 creator A5044281693 @default.
• W4210644602 creator A5045336762 @default.
• W4210644602 creator A5045925125 @default.
• W4210644602 creator A5049272413 @default.
• W4210644602 creator A5052777043 @default.
• W4210644602 creator A5053823114 @default.
• W4210644602 creator A5063618245 @default.
• W4210644602 creator A5064715597 @default.
• W4210644602 creator A5065329522 @default.
• W4210644602 creator A5066198297 @default.
• W4210644602 creator A5075328681 @default.
• W4210644602 creator A5079896142 @default.
• W4210644602 creator A5083126550 @default.
• W4210644602 date "2022-02-02" @default.
• W4210644602 modified "2023-10-17" @default.
• W4210644602 title "Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging <i>In Vivo, Ex Vivo</i>, and <i>In Situ</i>" @default.
• W4210644602 cites W1236654308 @default.
• W4210644602 cites W1707007402 @default.
• W4210644602 cites W1770306429 @default.
• W4210644602 cites W1965694893 @default.
• W4210644602 cites W1966460610 @default.
• W4210644602 cites W1971620413 @default.
• W4210644602 cites W1974309635 @default.
• W4210644602 cites W1978654303 @default.
• W4210644602 cites W1980195389 @default.
• W4210644602 cites W1984014880 @default.
• W4210644602 cites W1985859986 @default.
• W4210644602 cites W1993575340 @default.
• W4210644602 cites W1997479687 @default.
• W4210644602 cites W1997730366 @default.
• W4210644602 cites W2004150448 @default.
• W4210644602 cites W2004937569 @default.
• W4210644602 cites W2005998801 @default.
• W4210644602 cites W2006512709 @default.
• W4210644602 cites W2008869160 @default.
• W4210644602 cites W2011032800 @default.
• W4210644602 cites W2011809692 @default.
• W4210644602 cites W2014358738 @default.
• W4210644602 cites W2014700803 @default.
• W4210644602 cites W2019099719 @default.
• W4210644602 cites W2023074414 @default.
• W4210644602 cites W2025410711 @default.
• W4210644602 cites W2028512575 @default.
• W4210644602 cites W2030996837 @default.
• W4210644602 cites W2031084334 @default.
• W4210644602 cites W2032706441 @default.
• W4210644602 cites W2033503179 @default.
• W4210644602 cites W2038510533 @default.
• W4210644602 cites W2047172201 @default.
• W4210644602 cites W2048313558 @default.
• W4210644602 cites W2050613857 @default.
• W4210644602 cites W2052230654 @default.
• W4210644602 cites W2054472394 @default.
• W4210644602 cites W2057315451 @default.
• W4210644602 cites W2059139365 @default.
• W4210644602 cites W2063575064 @default.
• W4210644602 cites W2064119981 @default.
• W4210644602 cites W2064158921 @default.
• W4210644602 cites W2066671159 @default.
• W4210644602 cites W2067203318 @default.
• W4210644602 cites W2069237192 @default.
• W4210644602 cites W2070855360 @default.
• W4210644602 cites W2072587957 @default.
• W4210644602 cites W2076633494 @default.
• W4210644602 cites W2078947783 @default.
• W4210644602 cites W2080243002 @default.
• W4210644602 cites W2080860848 @default.
• W4210644602 cites W2082454728 @default.
• W4210644602 cites W2083249145 @default.
• W4210644602 cites W2092877053 @default.
• W4210644602 cites W2094469434 @default.
• W4210644602 cites W2094941678 @default.
• W4210644602 cites W2096428863 @default.
• W4210644602 cites W2101312385 @default.
• W4210644602 cites W2101407387 @default.
• W4210644602 cites W2115907801 @default.
• W4210644602 cites W2117398327 @default.
• W4210644602 cites W2118278569 @default.
• W4210644602 cites W2121626779 @default.
• W4210644602 cites W2122088044 @default.
• W4210644602 cites W2131348155 @default.
• W4210644602 cites W2131761283 @default.
• W4210644602 cites W2132160740 @default.
• W4210644602 cites W2143345040 @default.
• W4210644602 cites W2143463421 @default.
• W4210644602 cites W2145697808 @default.
• W4210644602 cites W2147364425 @default.
• W4210644602 cites W2148060280 @default.

• next