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- W4210653875 abstract "Clopidogrel is a prodrug chiefly metabolized by the hepatic isoenzyme CYP2C19 to its active metabolite that inhibits the platelet aggregation. It has been proven in many populations that the genetic polymorphism of CYP2C19 has influence on the pharmacokinetic and or pharmacodynamics of this drug and resulting in high inter-individual variability in the treatment outcomes. As CYP2C19 genetic polymorphism is highly prevalent among the Asian population, the influence of the same on the pharmacokinetics and; thereby, the pharmacodynamics of clopidogrel needs more attention. Using the pharmacogenetic information for drug therapy could help overcome these issues and to optimize the dosage regimen of clopidogrel, this review advocates the precision medicine approach for reducing the clopidogrel resistance and adverse cardiovascular events." @default.
- W4210653875 created "2022-02-08" @default.
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- W4210653875 date "2022-02-01" @default.
- W4210653875 modified "2023-09-27" @default.
- W4210653875 title "Dosage optimization of clopidogrel via a precision medicine approach: the way forward" @default.
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- W4210653875 doi "https://doi.org/10.2217/pgs-2020-0198" @default.
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