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• W4210661813 abstract "Rapid adenosine signaling has been detected spontaneously or after mechanical stimulation in the brain, providing rapid neuromodulation in a local area. To measure rapid adenosine signaling, a single carbon-fiber microelectrode has traditionally been used, which limits spatial resolution and an understanding of regional coordination. In this study, we utilized dual-channel fast-scan cyclic voltammetry to measure the spontaneous or mechanically stimulated adenosine release at two electrodes placed at different spacings in hippocampal CA1 mouse brain slices. For mechanically stimulated adenosine release, adenosine can be detected up to 150 μm away from where it was stimulated, although the signal is smaller and delayed. While spontaneous adenosine transients were detected at both electrodes, only 10 percent of the events were detected concurrently, and that number was similar at 50 and 200 μm electrode spacings. Thus, most adenosine transients were not caused by the widespread coordination of release. There was no evidence of diffusion of spontaneous transients to a second electrode 50-200 μm away. This study shows that spontaneous adenosine events are very localized and thus provide only local neuromodulation. Injury, such as mechanical stimulation, allows adenosine to diffuse farther, but the neuroprotective effects are still regional. These results provide a better understanding of the spatial and temporal profiles of adenosine available to act at receptors, which is crucial for future studies that design neuroprotective treatments based on rapid adenosine signaling." @default.
• W4210661813 created "2022-02-08" @default.
• W4210661813 creator A5032109168 @default.
• W4210661813 creator A5081790927 @default.
• W4210661813 date "2022-01-25" @default.
• W4210661813 modified "2023-09-26" @default.
• W4210661813 title "Dual-Channel Electrochemical Measurements Reveal Rapid Adenosine is Localized in Brain Slices" @default.
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• W4210661813 doi "https://doi.org/10.1021/acschemneuro.1c00679" @default.
• W4210661813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35077156" @default.
• W4210661813 hasPublicationYear "2022" @default.
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