FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210667110> ?p ?o ?g. }

• W4210667110 abstract "Seasonal influenza vaccination takes into account primarily hemagglutinin (HA)-specific neutralizing antibody responses. However, the accumulation of substitutions in the antigenic regions of HA (i.e., antigenic drift) occasionally results in a mismatch between the vaccine and circulating strains. To prevent poor vaccine performance, we investigated whether an antigenically matched neuraminidase (NA) may compensate for reduced vaccine efficacy due to a mismatched HA. Ferrets were vaccinated twice with adjuvanted split inactivated influenza vaccines containing homologous HA and NA (vacH3N2), only homologous HA (vacH3N1), only homologous NA (vacH1N2), heterologous HA and NA (vacH1N1), or phosphate-buffered saline (vacPBS), followed by challenge with H3N2 virus (A/Netherlands/16190/1968). Ferrets vaccinated with homologous HA (vacH3N2 and vacH3N1) displayed minimum fever and weight loss compared to vacH1N1 and vacPBS ferrets, while ferrets vaccinated with NA-matched vacH1N2 displayed intermediate fever and weight loss. Vaccination with vacH1N2 further led to a reduction in virus shedding from the nose and undetectable virus titers in the lower respiratory tract, similarly to when the homologous vacH3N2 was used. Some protection was observed upon vacH1N1 vaccination, but this was not comparable to that observed for vacH1N2, again highlighting the important role of NA in vaccine-induced protection. These results illustrate that NA antibodies can prevent severe disease caused by influenza virus infection and that an antigenically matched NA in seasonal vaccines might prevent lower respiratory tract complications. This underlines the importance of considering NA during the yearly vaccine strain selection process, which may be particularly beneficial in seasons when the HA component of the vaccine is mismatched. IMPORTANCE Despite the availability of vaccines, influenza virus infections continue to cause substantial morbidity and mortality in humans. Currently available influenza vaccines take primarily the hemagglutinin (HA) into account, but the highly variable nature of this protein as a result of antigenic drift has led to a recurrent decline in vaccine effectiveness. While the protective effect of neuraminidase (NA) antibodies has been highlighted by several studies, there are no requirements with regard to quantity or quality of NA in licensed vaccines, and NA immunity remains largely unexploited. Since antigenic changes in HA and NA are thought to occur asynchronously, NA immunity could compensate for reduced vaccine efficacy when drift in HA occurs. By matching and mismatching the HA and NA components of monovalent split inactivated vaccines, we demonstrated the potential of NA immunity to protect against disease, virus replication in the lower respiratory tract, and virus shedding in the ferret model." @default.
• W4210667110 created "2022-02-08" @default.
• W4210667110 creator A5008146809 @default.
• W4210667110 creator A5025392719 @default.
• W4210667110 creator A5035749443 @default.
• W4210667110 creator A5037869659 @default.
• W4210667110 creator A5044926437 @default.
• W4210667110 creator A5046072546 @default.
• W4210667110 creator A5048080933 @default.
• W4210667110 creator A5055462574 @default.
• W4210667110 creator A5057567289 @default.
• W4210667110 creator A5064800797 @default.
• W4210667110 creator A5067643421 @default.
• W4210667110 creator A5086491948 @default.
• W4210667110 date "2022-03-23" @default.
• W4210667110 modified "2023-10-10" @default.
• W4210667110 title "Contribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model" @default.
• W4210667110 cites W1508264729 @default.
• W4210667110 cites W1808739935 @default.
• W4210667110 cites W1964088165 @default.
• W4210667110 cites W1965540493 @default.
• W4210667110 cites W1969266602 @default.
• W4210667110 cites W1972280510 @default.
• W4210667110 cites W1980177337 @default.
• W4210667110 cites W1982394675 @default.
• W4210667110 cites W1984221593 @default.
• W4210667110 cites W1999441390 @default.
• W4210667110 cites W2013574284 @default.
• W4210667110 cites W2040173124 @default.
• W4210667110 cites W2041114103 @default.
• W4210667110 cites W2047278455 @default.
• W4210667110 cites W2060539718 @default.
• W4210667110 cites W2064958841 @default.
• W4210667110 cites W2082104694 @default.
• W4210667110 cites W2084959328 @default.
• W4210667110 cites W2087447110 @default.
• W4210667110 cites W2091527885 @default.
• W4210667110 cites W2100624829 @default.
• W4210667110 cites W2105842989 @default.
• W4210667110 cites W2106367546 @default.
• W4210667110 cites W2107587363 @default.
• W4210667110 cites W2108358599 @default.
• W4210667110 cites W2113352022 @default.
• W4210667110 cites W2117430529 @default.
• W4210667110 cites W2119621200 @default.
• W4210667110 cites W2129220932 @default.
• W4210667110 cites W2134902321 @default.
• W4210667110 cites W2136713302 @default.
• W4210667110 cites W2144155542 @default.
• W4210667110 cites W2161637522 @default.
• W4210667110 cites W2164759517 @default.
• W4210667110 cites W2314489476 @default.
• W4210667110 cites W2338736253 @default.
• W4210667110 cites W2529693366 @default.
• W4210667110 cites W2603791674 @default.
• W4210667110 cites W2624708886 @default.
• W4210667110 cites W2775569101 @default.
• W4210667110 cites W2788638702 @default.
• W4210667110 cites W2795794761 @default.
• W4210667110 cites W2802410352 @default.
• W4210667110 cites W2921802962 @default.
• W4210667110 cites W2946611861 @default.
• W4210667110 cites W2982030442 @default.
• W4210667110 cites W3005033296 @default.
• W4210667110 cites W3016394521 @default.
• W4210667110 cites W3086796595 @default.
• W4210667110 cites W3143592654 @default.
• W4210667110 cites W3154332013 @default.
• W4210667110 cites W3157009081 @default.
• W4210667110 doi "https://doi.org/10.1128/jvi.01959-21" @default.
• W4210667110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35107371" @default.
• W4210667110 hasPublicationYear "2022" @default.
• W4210667110 type Work @default.
• W4210667110 citedByCount "6" @default.
• W4210667110 countsByYear W42106671102022 @default.
• W4210667110 countsByYear W42106671102023 @default.
• W4210667110 crossrefType "journal-article" @default.
• W4210667110 hasAuthorship W4210667110A5008146809 @default.
• W4210667110 hasAuthorship W4210667110A5025392719 @default.
• W4210667110 hasAuthorship W4210667110A5035749443 @default.
• W4210667110 hasAuthorship W4210667110A5037869659 @default.
• W4210667110 hasAuthorship W4210667110A5044926437 @default.
• W4210667110 hasAuthorship W4210667110A5046072546 @default.
• W4210667110 hasAuthorship W4210667110A5048080933 @default.
• W4210667110 hasAuthorship W4210667110A5055462574 @default.
• W4210667110 hasAuthorship W4210667110A5057567289 @default.
• W4210667110 hasAuthorship W4210667110A5064800797 @default.
• W4210667110 hasAuthorship W4210667110A5067643421 @default.
• W4210667110 hasAuthorship W4210667110A5086491948 @default.
• W4210667110 hasBestOaLocation W42106671101 @default.
• W4210667110 hasConcept C104317684 @default.
• W4210667110 hasConcept C134164806 @default.
• W4210667110 hasConcept C147483822 @default.
• W4210667110 hasConcept C159047783 @default.
• W4210667110 hasConcept C159654299 @default.
• W4210667110 hasConcept C191942190 @default.
• W4210667110 hasConcept C203014093 @default.
• W4210667110 hasConcept C22070199 @default.
• W4210667110 hasConcept C2522874641 @default.
• W4210667110 hasConcept C2778692840 @default.

• next