Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210688520> ?p ?o ?g. }
- W4210688520 abstract "Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on HER2-targeted therapies. Deregulation in HER2 signaling pathways is accompanied by sustained tumor cells growth concomitant with their migration and also tumor angiogenesis and metastasis by stimulation of proliferation of a network of blood vessels. A large number of studies have provided clear evidence that the emerging HER2-directed treatments could be the outcome of patients suffering from HER2 positive breast and also gastric/gastroesophageal cancers. Thanks to its great anti-tumor competence, immunotherapy using HER2-specific chimeric antigen receptor (CAR) expressing immune cell has recently attracted increasing attention. Human T cells and also natural killer (NK) cells can largely be found in the tumor microenvironment, mainly contributing to the tumor immune surveillance. Such properties make them perfect candidate for genetically modification to express constructed CARs. Herein, we will describe the potential targets of the HER2 signaling in tumor cells to clarify HER2-mediated tumorigenesis and also discuss recent findings respecting the HER2-specific CAR-expressing immune cells (CAR T and CAR NK cell) for the treatment of HER2-expressing tumors." @default.
- W4210688520 created "2022-02-08" @default.
- W4210688520 creator A5008877659 @default.
- W4210688520 creator A5017273456 @default.
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- W4210688520 creator A5057841900 @default.
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- W4210688520 date "2022-01-29" @default.
- W4210688520 modified "2023-10-05" @default.
- W4210688520 title "Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress" @default.
- W4210688520 cites W109340176 @default.
- W4210688520 cites W1493661170 @default.
- W4210688520 cites W1506365371 @default.
- W4210688520 cites W1595135214 @default.
- W4210688520 cites W1800095175 @default.
- W4210688520 cites W1965850768 @default.
- W4210688520 cites W1973421681 @default.
- W4210688520 cites W1974562505 @default.
- W4210688520 cites W1974784117 @default.
- W4210688520 cites W1980311294 @default.
- W4210688520 cites W1984617792 @default.
- W4210688520 cites W1985827132 @default.
- W4210688520 cites W1991647049 @default.
- W4210688520 cites W1998007325 @default.
- W4210688520 cites W2003539449 @default.
- W4210688520 cites W2011395706 @default.
- W4210688520 cites W2014476931 @default.
- W4210688520 cites W2016523043 @default.
- W4210688520 cites W2017737191 @default.
- W4210688520 cites W2018849561 @default.
- W4210688520 cites W2018863770 @default.
- W4210688520 cites W2018939316 @default.
- W4210688520 cites W2025068963 @default.
- W4210688520 cites W2027863358 @default.
- W4210688520 cites W2030229250 @default.
- W4210688520 cites W2033488181 @default.
- W4210688520 cites W2038702089 @default.
- W4210688520 cites W2041140906 @default.
- W4210688520 cites W2044455803 @default.
- W4210688520 cites W2051841612 @default.
- W4210688520 cites W2056579307 @default.
- W4210688520 cites W2058526541 @default.
- W4210688520 cites W2064394610 @default.
- W4210688520 cites W2068854353 @default.
- W4210688520 cites W2071798310 @default.
- W4210688520 cites W2072015736 @default.
- W4210688520 cites W2072996947 @default.
- W4210688520 cites W2074043387 @default.
- W4210688520 cites W2077374035 @default.
- W4210688520 cites W2078059553 @default.
- W4210688520 cites W2078454159 @default.
- W4210688520 cites W2087209798 @default.
- W4210688520 cites W2090712779 @default.
- W4210688520 cites W2093654081 @default.
- W4210688520 cites W2093912650 @default.
- W4210688520 cites W2097637166 @default.
- W4210688520 cites W2101339244 @default.
- W4210688520 cites W2104543708 @default.
- W4210688520 cites W2105879190 @default.
- W4210688520 cites W2110641339 @default.
- W4210688520 cites W2114283516 @default.
- W4210688520 cites W2119909440 @default.
- W4210688520 cites W2120672212 @default.
- W4210688520 cites W2124637769 @default.
- W4210688520 cites W2125608197 @default.
- W4210688520 cites W2127033802 @default.
- W4210688520 cites W2129525703 @default.
- W4210688520 cites W2139185517 @default.
- W4210688520 cites W2141393790 @default.
- W4210688520 cites W2154946742 @default.
- W4210688520 cites W2155008430 @default.
- W4210688520 cites W2159222883 @default.
- W4210688520 cites W2161187689 @default.
- W4210688520 cites W2167121370 @default.
- W4210688520 cites W2169344919 @default.
- W4210688520 cites W2169782526 @default.
- W4210688520 cites W2181222348 @default.
- W4210688520 cites W2192976324 @default.
- W4210688520 cites W2212171768 @default.
- W4210688520 cites W2237678788 @default.
- W4210688520 cites W2260497117 @default.
- W4210688520 cites W2262992387 @default.
- W4210688520 cites W2263449577 @default.
- W4210688520 cites W2325780118 @default.
- W4210688520 cites W2331962566 @default.
- W4210688520 cites W2397006483 @default.
- W4210688520 cites W2402659606 @default.
- W4210688520 cites W2417352852 @default.
- W4210688520 cites W2460144533 @default.
- W4210688520 cites W2481298264 @default.
- W4210688520 cites W2507936305 @default.
- W4210688520 cites W2558333564 @default.
- W4210688520 cites W2562960180 @default.
- W4210688520 cites W2566001673 @default.
- W4210688520 cites W2572742978 @default.
- W4210688520 cites W2574942548 @default.