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- W4210689591 abstract "Abstract Comorbid Type 2 diabetes (T2D), a metabolic complication of obesity, associates with worse cancer outcomes for prostate, breast, head and neck, colorectal and several other solid tumors. However, the molecular mechanisms remain poorly understood. Emerging evidence shows that exosomes carry miRNAs in blood that encode the metabolic status of originating tissues and deliver their cargo to target tissues to modulate expression of critical genes. Exosomal communication potentially connects abnormal metabolism to cancer progression. Here, we hypothesized that T2D plasma exosomes induce epithelial-mesenchymal transition (EMT) and immune checkpoints in prostate cancer cells. We demonstrate that plasma exosomes from subjects with T2D induce EMT features in prostate cancer cells and upregulate the checkpoint genes CD274 and CD155 . We demonstrate that specific exosomal miRNAs that are differentially abundant in plasma of T2D adults compared to nondiabetic controls (miR374a-5p, miR-93-5p and let-7b-3p) are delivered to cancer cells, thereby regulating critical target genes. We build on our previous reports showing BRD4 controls migration and dissemination of castration-resistant prostate cancer, and transcription of key EMT genes, to show that T2D exosomes require BRD4 to drive EMT and immune ligand expression. We validate our findings with gene set enrichment analysis of human prostate tumor tissue in TGCA genomic data. These results suggest novel, non-invasive approaches to evaluate and potentially block progression of prostate and other cancers in patients with comorbid T2D." @default.
- W4210689591 created "2022-02-08" @default.
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- W4210689591 date "2022-02-04" @default.
- W4210689591 modified "2023-09-26" @default.
- W4210689591 title "Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease" @default.
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- W4210689591 cites W1987409881 @default.
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- W4210689591 cites W2032315444 @default.
- W4210689591 cites W2035446368 @default.
- W4210689591 cites W2035844407 @default.
- W4210689591 cites W2046453881 @default.
- W4210689591 cites W2049598073 @default.
- W4210689591 cites W2083393874 @default.
- W4210689591 cites W2084371653 @default.
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- W4210689591 cites W2101821830 @default.
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- W4210689591 cites W2335064330 @default.
- W4210689591 cites W2335679869 @default.
- W4210689591 cites W2416273502 @default.
- W4210689591 cites W2508265039 @default.
- W4210689591 cites W2513352023 @default.
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- W4210689591 cites W2906749248 @default.
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- W4210689591 doi "https://doi.org/10.1101/2022.02.01.478722" @default.
- W4210689591 hasPublicationYear "2022" @default.
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