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- W4210706809 abstract "Abstract Enlarged perivascular spaces (PVS) are considered a biomarker for vascular pathology and are observed in normal aging and neurological conditions; however, research on the role of PVS in health and disease are hindered by the lack of knowledge regarding the normative time course of PVS alterations with age. To this end, we characterized the influence of age, sex and cognitive performance on PVS anatomical characteristics in a large cross-sectional cohort (∼1400) of healthy subjects between 8 and 90 years of age using multimodal structural MRI data. Our results show age is associated with wider and more numerous MRI-visible PVS over the course of the lifetime with spatially-varying patterns of PVS enlargement trajectories. In particular, regions with low PVS volume fraction in childhood are associated with rapid age-related PVS enlargement (e.g., temporal regions), while regions with high PVS volume fraction in childhood are associated with minimal age-related PVS alterations (e.g., limbic regions). PVS burden was significantly elevated in males compared to females with differing morphological time courses with age. Together, these findings contribute to our understanding of perivascular physiology across the healthy lifespan and provide a normative reference for the spatial distribution of PVS enlargement patterns to which pathological alterations can be compared." @default.
- W4210706809 created "2022-02-08" @default.
- W4210706809 creator A5012771982 @default.
- W4210706809 creator A5027984749 @default.
- W4210706809 creator A5034709143 @default.
- W4210706809 creator A5058078272 @default.
- W4210706809 date "2022-01-27" @default.
- W4210706809 modified "2023-10-16" @default.
- W4210706809 title "Brain perivascular space imaging across the human lifespan" @default.
- W4210706809 cites W1177847716 @default.
- W4210706809 cites W1731947656 @default.
- W4210706809 cites W1899329334 @default.
- W4210706809 cites W1967448179 @default.
- W4210706809 cites W1969726234 @default.
- W4210706809 cites W1979924329 @default.
- W4210706809 cites W1982252004 @default.
- W4210706809 cites W1983208069 @default.
- W4210706809 cites W1990814941 @default.
- W4210706809 cites W1991792523 @default.
- W4210706809 cites W2004293194 @default.
- W4210706809 cites W2006277962 @default.
- W4210706809 cites W2012403261 @default.
- W4210706809 cites W2020044743 @default.
- W4210706809 cites W2023114245 @default.
- W4210706809 cites W2024729467 @default.
- W4210706809 cites W2024955728 @default.
- W4210706809 cites W2028963876 @default.
- W4210706809 cites W2030827970 @default.
- W4210706809 cites W2030944096 @default.
- W4210706809 cites W2031603518 @default.
- W4210706809 cites W2039605938 @default.
- W4210706809 cites W2051610846 @default.
- W4210706809 cites W2057291185 @default.
- W4210706809 cites W2062905260 @default.
- W4210706809 cites W2068472245 @default.
- W4210706809 cites W2077725268 @default.
- W4210706809 cites W2078207339 @default.
- W4210706809 cites W2078813675 @default.
- W4210706809 cites W2086974237 @default.
- W4210706809 cites W2089435027 @default.
- W4210706809 cites W2094258912 @default.
- W4210706809 cites W2098819343 @default.
- W4210706809 cites W2100314515 @default.
- W4210706809 cites W2101135654 @default.
- W4210706809 cites W2103481737 @default.
- W4210706809 cites W2104842795 @default.
- W4210706809 cites W2115126473 @default.
- W4210706809 cites W2115505196 @default.
- W4210706809 cites W211905087 @default.
- W4210706809 cites W2121369614 @default.
- W4210706809 cites W2124127780 @default.
- W4210706809 cites W2128278384 @default.
- W4210706809 cites W2129534965 @default.
- W4210706809 cites W2134730295 @default.
- W4210706809 cites W2149722331 @default.
- W4210706809 cites W2156717321 @default.
- W4210706809 cites W2157270343 @default.
- W4210706809 cites W2157848968 @default.
- W4210706809 cites W2158742097 @default.
- W4210706809 cites W2159899308 @default.
- W4210706809 cites W2167183660 @default.
- W4210706809 cites W2172230288 @default.
- W4210706809 cites W2323566945 @default.
- W4210706809 cites W2591605663 @default.
- W4210706809 cites W2602043626 @default.
- W4210706809 cites W2612273352 @default.
- W4210706809 cites W2742497781 @default.
- W4210706809 cites W2766060569 @default.
- W4210706809 cites W2768025036 @default.
- W4210706809 cites W2768806315 @default.
- W4210706809 cites W2768909676 @default.
- W4210706809 cites W2886797059 @default.
- W4210706809 cites W2888149555 @default.
- W4210706809 cites W2890224686 @default.
- W4210706809 cites W2892387330 @default.
- W4210706809 cites W2893411620 @default.
- W4210706809 cites W2895786705 @default.
- W4210706809 cites W2896555885 @default.
- W4210706809 cites W2914584287 @default.
- W4210706809 cites W2950086191 @default.
- W4210706809 cites W2964384375 @default.
- W4210706809 cites W2970100807 @default.
- W4210706809 cites W2972368830 @default.
- W4210706809 cites W2993515580 @default.
- W4210706809 cites W3007815224 @default.
- W4210706809 cites W3016491660 @default.
- W4210706809 cites W3022500555 @default.
- W4210706809 cites W3026922848 @default.
- W4210706809 cites W3084363438 @default.
- W4210706809 cites W3092519303 @default.
- W4210706809 cites W3095187647 @default.
- W4210706809 cites W3100311673 @default.
- W4210706809 cites W3112639274 @default.
- W4210706809 cites W3125874714 @default.
- W4210706809 cites W3143505018 @default.
- W4210706809 cites W4239096779 @default.
- W4210706809 doi "https://doi.org/10.1101/2022.01.25.475887" @default.
- W4210706809 hasPublicationYear "2022" @default.
- W4210706809 type Work @default.
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