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- W4210725303 abstract "Living cells exposed to stressful environmental situations can elicit cellular responses that guarantee maximal cell survival. Most of these responses are mediated by mitogen-activated protein kinase (MAPK) cascades, which are highly conserved from yeast to humans. Cell wall damage conditions in the yeast Saccharomyces cerevisiae elicit rescue mechanisms mainly associated with reprogramming specific transcriptional responses via the cell wall integrity (CWI) pathway. Regulation of gene expression by this pathway is coordinated by the MAPK Slt2/Mpk1, mainly via Rlm1 and, to a lesser extent, through SBF (Swi4/Swi6) transcription factors. In this review, we summarize the molecular mechanisms controlling gene expression upon cell wall stress and the role of chromatin structure in these processes. Some of these mechanisms are also discussed in the context of other stresses governed by different yeast MAPK pathways. Slt2 regulates both transcriptional initiation and elongation by interacting with chromatin at the promoter and coding regions of CWI-responsive genes but using different mechanisms for Rlm1- and SBF-dependent genes. Since MAPK pathways are very well conserved in eukaryotic cells and are essential for controlling cellular physiology, improving our knowledge regarding how they regulate gene expression could impact the future identification of novel targets for therapeutic intervention." @default.
- W4210725303 created "2022-02-08" @default.
- W4210725303 creator A5044960006 @default.
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- W4210725303 creator A5058230336 @default.
- W4210725303 creator A5065691817 @default.
- W4210725303 creator A5090425163 @default.
- W4210725303 date "2022-02-04" @default.
- W4210725303 modified "2023-10-01" @default.
- W4210725303 title "Control of Gene Expression via the Yeast CWI Pathway" @default.
- W4210725303 cites W1509357297 @default.
- W4210725303 cites W1533604650 @default.
- W4210725303 cites W1552907764 @default.
- W4210725303 cites W1556555540 @default.
- W4210725303 cites W1597773685 @default.
- W4210725303 cites W1615851665 @default.
- W4210725303 cites W1744656122 @default.
- W4210725303 cites W1857242751 @default.
- W4210725303 cites W1891964745 @default.
- W4210725303 cites W1907909844 @default.
- W4210725303 cites W1938343654 @default.
- W4210725303 cites W1964318436 @default.
- W4210725303 cites W1965114482 @default.
- W4210725303 cites W1971765644 @default.
- W4210725303 cites W1975035065 @default.
- W4210725303 cites W1975676532 @default.
- W4210725303 cites W1976761307 @default.
- W4210725303 cites W1980006363 @default.
- W4210725303 cites W1981585431 @default.
- W4210725303 cites W1981977553 @default.
- W4210725303 cites W1988051570 @default.
- W4210725303 cites W1988972530 @default.
- W4210725303 cites W1991036368 @default.
- W4210725303 cites W1992902970 @default.
- W4210725303 cites W1994752994 @default.
- W4210725303 cites W1995277971 @default.
- W4210725303 cites W1995559933 @default.
- W4210725303 cites W1997308071 @default.
- W4210725303 cites W2001360952 @default.
- W4210725303 cites W2008240036 @default.
- W4210725303 cites W2008619144 @default.
- W4210725303 cites W2009559661 @default.
- W4210725303 cites W2012466702 @default.
- W4210725303 cites W2013571070 @default.
- W4210725303 cites W2014119967 @default.
- W4210725303 cites W2016786878 @default.
- W4210725303 cites W2020747998 @default.
- W4210725303 cites W2021510896 @default.
- W4210725303 cites W2025744458 @default.
- W4210725303 cites W2026368142 @default.
- W4210725303 cites W2035849174 @default.
- W4210725303 cites W2038372746 @default.
- W4210725303 cites W2041847099 @default.
- W4210725303 cites W2043148368 @default.
- W4210725303 cites W2043679962 @default.
- W4210725303 cites W2046638114 @default.
- W4210725303 cites W2048912944 @default.
- W4210725303 cites W2048988294 @default.
- W4210725303 cites W2050690313 @default.
- W4210725303 cites W2051756496 @default.
- W4210725303 cites W2052837845 @default.
- W4210725303 cites W2055588739 @default.
- W4210725303 cites W2057894015 @default.
- W4210725303 cites W2057968730 @default.
- W4210725303 cites W2058101616 @default.
- W4210725303 cites W2063679723 @default.
- W4210725303 cites W2067393096 @default.
- W4210725303 cites W2069545688 @default.
- W4210725303 cites W2071113403 @default.
- W4210725303 cites W2073354180 @default.
- W4210725303 cites W2074743540 @default.
- W4210725303 cites W2075213209 @default.
- W4210725303 cites W2079122560 @default.
- W4210725303 cites W2081954942 @default.
- W4210725303 cites W2082020317 @default.
- W4210725303 cites W2082605090 @default.
- W4210725303 cites W2082847873 @default.
- W4210725303 cites W2083329762 @default.
- W4210725303 cites W2086202782 @default.
- W4210725303 cites W2089060759 @default.
- W4210725303 cites W2089245424 @default.
- W4210725303 cites W2090120584 @default.
- W4210725303 cites W2096083625 @default.
- W4210725303 cites W2097127232 @default.
- W4210725303 cites W2098665858 @default.
- W4210725303 cites W2099826949 @default.
- W4210725303 cites W2100716254 @default.
- W4210725303 cites W2103082923 @default.
- W4210725303 cites W2103302926 @default.
- W4210725303 cites W2103491947 @default.
- W4210725303 cites W2104006062 @default.
- W4210725303 cites W2104254337 @default.
- W4210725303 cites W2106031809 @default.
- W4210725303 cites W2106248803 @default.
- W4210725303 cites W2109143007 @default.
- W4210725303 cites W2111374113 @default.
- W4210725303 cites W2111732181 @default.
- W4210725303 cites W2114136380 @default.