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- W4210742344 endingPage "582" @default.
- W4210742344 startingPage "573" @default.
- W4210742344 abstract "Basal cell carcinoma (BCC) is the most common skin cancer in humans. Recently, BCCs were suggested to be classified into 'easy to treat' and 'difficult to treat,' and different therapeutic options are suggested for their management.In this review, the authors discuss treatment options that are approved, recommended for, or are still in development for treatment of BCC. The review covers approved local therapies, such as imiquimod and 5-fluorouracil, and systemic therapies, such as hedgehog inhibitors. New medical agents, investigated in clinical trials, are reviewed. These include: targeted therapies, such as GLI antagonists or anti-VEGFR agents, immunotherapies, such as checkpoint inhibitors, recombinant cytokines or silencing RNA, as well as intralesional virotherapies with modified adeno- or herpes viruses.The progress made in recent years has improved the management of patients with advanced BCC; however, neither tumor targeting nor immune system engaging agents provide a cure. New treatment approaches directed not only to known targets but also the tumor microenvironment are in development and are anticipated to improve the management of difficult to treat BCC." @default.
- W4210742344 created "2022-02-08" @default.
- W4210742344 creator A5013521399 @default.
- W4210742344 creator A5016968396 @default.
- W4210742344 creator A5017247203 @default.
- W4210742344 creator A5056878063 @default.
- W4210742344 creator A5089297467 @default.
- W4210742344 date "2022-01-27" @default.
- W4210742344 modified "2023-09-30" @default.
- W4210742344 title "Advances in the drug management of basal cell carcinoma" @default.
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