Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210751516> ?p ?o ?g. }
- W4210751516 endingPage "978" @default.
- W4210751516 startingPage "970" @default.
- W4210751516 abstract "Approximately 1 in 36 children are diagnosed with autism spectrum disorder (ASD). The disorder is four times more common in males than in females. Zinc deficiency and mutations in SHANK2 and SHANK3 (members of a family of excitatory postsynaptic scaffolding proteins) are all risk factors that may contribute to the pathophysiology of the disease. The presence of shankopathies (loss of one copy of the SHANK3 gene) can lead to the development of Phelan-McDermid syndrome (PMDS)-a rare genetic disorder characterized by developmental delay, intellectual disability, poor motor tone, and ASD-like symptoms. We reviewed the relationship between zinc, ASD, and PMDS as well as the effect of zinc supplementation in improving symptoms of ASD and PMDS based on 22 studies published within 6 years (2015-2020). Zinc deficiency (assessed by either dietary intake, blood, hair, or tooth matrix) was shown to be highly prevalent in ASD and PMDS patients as well as in preclinical models of ASD and PMDS. Zinc supplements improved the behavioral deficits in animal models of ASD and PMDS. Clinical trials are still needed to validate the beneficial therapeutic effects of zinc supplements in ASD and PMDS patients." @default.
- W4210751516 created "2022-02-08" @default.
- W4210751516 creator A5000312211 @default.
- W4210751516 creator A5006130348 @default.
- W4210751516 creator A5023058300 @default.
- W4210751516 creator A5029219321 @default.
- W4210751516 creator A5036453844 @default.
- W4210751516 creator A5055142582 @default.
- W4210751516 creator A5081640744 @default.
- W4210751516 date "2022-02-03" @default.
- W4210751516 modified "2023-10-13" @default.
- W4210751516 title "Zinc deficiency and supplementation in autism spectrum disorder and <scp>Phelan‐McDermid</scp> syndrome" @default.
- W4210751516 cites W1667338708 @default.
- W4210751516 cites W1872255622 @default.
- W4210751516 cites W1962159122 @default.
- W4210751516 cites W1963858631 @default.
- W4210751516 cites W1967764516 @default.
- W4210751516 cites W1968155359 @default.
- W4210751516 cites W1973138133 @default.
- W4210751516 cites W1983194657 @default.
- W4210751516 cites W1984283832 @default.
- W4210751516 cites W1984331840 @default.
- W4210751516 cites W1991772685 @default.
- W4210751516 cites W1994145782 @default.
- W4210751516 cites W1995454866 @default.
- W4210751516 cites W2003540539 @default.
- W4210751516 cites W2003831090 @default.
- W4210751516 cites W2005817756 @default.
- W4210751516 cites W2008718711 @default.
- W4210751516 cites W2011258416 @default.
- W4210751516 cites W2012491213 @default.
- W4210751516 cites W2016489565 @default.
- W4210751516 cites W2022609707 @default.
- W4210751516 cites W2031217837 @default.
- W4210751516 cites W2047772327 @default.
- W4210751516 cites W2064332273 @default.
- W4210751516 cites W2074258117 @default.
- W4210751516 cites W2077482892 @default.
- W4210751516 cites W2080287250 @default.
- W4210751516 cites W2087373760 @default.
- W4210751516 cites W2092828620 @default.
- W4210751516 cites W2106490877 @default.
- W4210751516 cites W2109002457 @default.
- W4210751516 cites W2110374888 @default.
- W4210751516 cites W2111110903 @default.
- W4210751516 cites W2123194540 @default.
- W4210751516 cites W2134914855 @default.
- W4210751516 cites W2141041915 @default.
- W4210751516 cites W2142239668 @default.
- W4210751516 cites W2147881724 @default.
- W4210751516 cites W2154511345 @default.
- W4210751516 cites W2157368272 @default.
- W4210751516 cites W2166384415 @default.
- W4210751516 cites W2310417648 @default.
- W4210751516 cites W2323422917 @default.
- W4210751516 cites W2327581584 @default.
- W4210751516 cites W2352734153 @default.
- W4210751516 cites W2555434491 @default.
- W4210751516 cites W2600098552 @default.
- W4210751516 cites W2620629113 @default.
- W4210751516 cites W2726271110 @default.
- W4210751516 cites W2735562864 @default.
- W4210751516 cites W2751300432 @default.
- W4210751516 cites W2784028610 @default.
- W4210751516 cites W2787232631 @default.
- W4210751516 cites W2794286333 @default.
- W4210751516 cites W2801551952 @default.
- W4210751516 cites W2801740650 @default.
- W4210751516 cites W2806188324 @default.
- W4210751516 cites W2836767872 @default.
- W4210751516 cites W2838558797 @default.
- W4210751516 cites W2895242578 @default.
- W4210751516 cites W2899268802 @default.
- W4210751516 cites W2908406027 @default.
- W4210751516 cites W2915170188 @default.
- W4210751516 cites W2975030365 @default.
- W4210751516 cites W3004830039 @default.
- W4210751516 cites W3014676394 @default.
- W4210751516 cites W3020286246 @default.
- W4210751516 cites W3021334131 @default.
- W4210751516 cites W3031353382 @default.
- W4210751516 cites W3047398645 @default.
- W4210751516 cites W38426550 @default.
- W4210751516 cites W4229611071 @default.
- W4210751516 doi "https://doi.org/10.1002/jnr.25019" @default.
- W4210751516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35114017" @default.
- W4210751516 hasPublicationYear "2022" @default.
- W4210751516 type Work @default.
- W4210751516 citedByCount "6" @default.
- W4210751516 countsByYear W42107515162022 @default.
- W4210751516 countsByYear W42107515162023 @default.
- W4210751516 crossrefType "journal-article" @default.
- W4210751516 hasAuthorship W4210751516A5000312211 @default.
- W4210751516 hasAuthorship W4210751516A5006130348 @default.
- W4210751516 hasAuthorship W4210751516A5023058300 @default.
- W4210751516 hasAuthorship W4210751516A5029219321 @default.
- W4210751516 hasAuthorship W4210751516A5036453844 @default.
- W4210751516 hasAuthorship W4210751516A5055142582 @default.