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• W4210755263 startingPage "457" @default.
• W4210755263 abstract "The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone very well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain, and it displays critical roles in neuroprotection by activating the GLP-1 receptor signaling pathways. GLP-1 enhances learning and memory in the hippocampus, promotes neurogenesis, decreases inflammation and apoptosis, modulates reward behavior, and reduces food intake. Its pharmacokinetics have been improved to enhance the peptide's half-life, enhancing exposure and time of action. The GLP-1 agonists are successfully in clinical use for the treatment of type-2 diabetes, obesity, and clinical evaluation for the treatment of neurodegenerative diseases." @default.
• W4210755263 created "2022-02-08" @default.
• W4210755263 creator A5022233474 @default.
• W4210755263 creator A5057841370 @default.
• W4210755263 creator A5074609207 @default.
• W4210755263 creator A5090051162 @default.
• W4210755263 date "2022-01-01" @default.
• W4210755263 modified "2023-09-30" @default.
• W4210755263 title "Effects of Glucagon-like peptide 1 (GLP-1) analogs in the hippocampus" @default.
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