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- W4210757307 abstract "Innate immunity is mediated by a variety of cell types, including microglia, macrophages, and neutrophils, and serves as the immune system's first line of defense. There are numerous pathways involved in innate immunity, including the interferon (IFN) pathway, TRK pathway, mitogen-activated protein kinase (MAPK) pathway, Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, interleukin (IL) pathways, chemokine pathways (CCR5), GSK signaling, and Fas signaling.JAK/STAT is one of these important signaling pathways and this review focused on JAK/STAT signaling pathway only. The overactivation of microglia and astrocytes influences JAK/STAT's role in neuroinflammatory disease by initiating innate immunity, orchestrating adaptive immune mechanisms, and ultimately constraining inflammatory and immunological responses. The JAK/STAT signaling pathway is one of the critical factors that promotes neuroinflammation in neurodegenerative diseases.Given the importance of the JAK/STAT pathway in neurodegenerative disease, this review discussed the feasibility of targeting the JAK/STAT pathway as a neuroprotective therapy for neurodegenerative diseases in near future." @default.
- W4210757307 created "2022-02-08" @default.
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- W4210757307 date "2021-07-01" @default.
- W4210757307 modified "2023-10-15" @default.
- W4210757307 title "Role of JAK/STAT in the Neuroinflammation and its Association with Neurological Disorders" @default.
- W4210757307 cites W1480927111 @default.
- W4210757307 cites W1607206274 @default.
- W4210757307 cites W1817666133 @default.
- W4210757307 cites W1876850155 @default.
- W4210757307 cites W1973454407 @default.
- W4210757307 cites W1977681992 @default.
- W4210757307 cites W1988160418 @default.
- W4210757307 cites W1993108139 @default.
- W4210757307 cites W1993573917 @default.
- W4210757307 cites W1994554610 @default.
- W4210757307 cites W1999218213 @default.
- W4210757307 cites W2000397914 @default.
- W4210757307 cites W2004805241 @default.
- W4210757307 cites W2021133027 @default.
- W4210757307 cites W2026287451 @default.
- W4210757307 cites W2034038847 @default.
- W4210757307 cites W2039395590 @default.
- W4210757307 cites W2041964216 @default.
- W4210757307 cites W2046927378 @default.
- W4210757307 cites W2052593121 @default.
- W4210757307 cites W2053815296 @default.
- W4210757307 cites W2059099306 @default.
- W4210757307 cites W2075490622 @default.
- W4210757307 cites W2083802827 @default.
- W4210757307 cites W2098038342 @default.
- W4210757307 cites W2107376426 @default.
- W4210757307 cites W2113617025 @default.
- W4210757307 cites W2117503265 @default.
- W4210757307 cites W2118742454 @default.
- W4210757307 cites W2121516058 @default.
- W4210757307 cites W2130295086 @default.
- W4210757307 cites W2132173287 @default.
- W4210757307 cites W2139815913 @default.
- W4210757307 cites W2141515445 @default.
- W4210757307 cites W2148159882 @default.
- W4210757307 cites W2156023352 @default.
- W4210757307 cites W2160239222 @default.
- W4210757307 cites W2162790692 @default.
- W4210757307 cites W2162893658 @default.
- W4210757307 cites W2163751922 @default.
- W4210757307 cites W2182121804 @default.
- W4210757307 cites W2205544783 @default.
- W4210757307 cites W2315720146 @default.
- W4210757307 cites W2329190288 @default.
- W4210757307 cites W2346322633 @default.
- W4210757307 cites W2510322558 @default.
- W4210757307 cites W2512528003 @default.
- W4210757307 cites W2528968729 @default.
- W4210757307 cites W2592397452 @default.
- W4210757307 cites W2594135991 @default.
- W4210757307 cites W2601742683 @default.
- W4210757307 cites W2602156859 @default.
- W4210757307 cites W2608543149 @default.
- W4210757307 cites W2613148122 @default.
- W4210757307 cites W2618219849 @default.
- W4210757307 cites W2718751133 @default.
- W4210757307 cites W2728496947 @default.
- W4210757307 cites W2734800566 @default.
- W4210757307 cites W2774835162 @default.
- W4210757307 cites W2802731336 @default.
- W4210757307 cites W2806388412 @default.
- W4210757307 cites W2887497469 @default.
- W4210757307 cites W2889787710 @default.
- W4210757307 cites W2890354388 @default.
- W4210757307 cites W2890627020 @default.
- W4210757307 cites W2894541720 @default.
- W4210757307 cites W2942222993 @default.
- W4210757307 cites W2965717703 @default.
- W4210757307 cites W2990235536 @default.
- W4210757307 cites W3000480166 @default.
- W4210757307 cites W3001721938 @default.
- W4210757307 cites W3014540555 @default.
- W4210757307 cites W3033026625 @default.
- W4210757307 cites W3084203681 @default.
- W4210757307 cites W3111509171 @default.
- W4210757307 cites W3196445684 @default.
- W4210757307 cites W4205416135 @default.
- W4210757307 cites W4211144854 @default.
- W4210757307 cites W51414459 @default.
- W4210757307 cites W605176161 @default.
- W4210757307 doi "https://doi.org/10.1177/09727531211070532" @default.
- W4210757307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35341232" @default.
- W4210757307 hasPublicationYear "2021" @default.
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