FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210757548> ?p ?o ?g. }

• W4210757548 endingPage "942" @default.
• W4210757548 startingPage "933" @default.
• W4210757548 abstract "Abstract Aim The aim of this work was to investigate whether nonsteroidal anti‐inflammatory drugs (NSAIDs) could be beneficial or harmful when used perioperatively for colorectal cancer patients, as inflammation may affect occult disease and anastomotic healing. Method This is a protocol‐based retrospective cohort study on colorectal cancer patients operated on between 2007 and 2012 at 21 hospitals in Sweden. NSAID exposure was retrieved from postoperative analgesia protocols, while outcomes and patient data were retrieved from the Swedish Colorectal Cancer Registry. Older or severely comorbid patients, as well as those with disseminated or nonradically operated tumours were excluded. Multivariable regression with adjustment for confounders was performed, estimating hazard ratios (HRs) for long‐term outcomes and odds ratios (ORs) for short‐term outcomes, including 95% confidence intervals (CIs). Results Some 6945 patients remained after exclusion, of whom 3996 were treated at hospitals where a NSAID protocol was in place. No association was seen between NSAIDs and recurrence‐free survival (HR 0.97, 95% CI 0.87–1.09). However, a reduction in cancer recurrence was detected (HR 0.83, 95% CI 0.72–0.95), which remained significant when stratifying into locoregional (HR 0.68, 95% CI 0.48–0.97) and distant recurrences (HR 0.85, 95% CI 0.74–0.98). Anastomotic leakage was less frequent (HR 0.69%, 95% CI 0.51–0.94) in the NSAID‐exposed, mainly due to a risk reduction in colo‐rectal and ileo‐rectal anastomoses (HR 0.47, 95% CI 0.33–0.68). Conclusion There was no association between NSAID exposure and recurrence‐free survival, but an association with reduced cancer recurrence and the rate of anastomotic leakage was detected, which may depend on tumour site and anastomotic location." @default.
• W4210757548 created "2022-02-08" @default.
• W4210757548 creator A5028320904 @default.
• W4210757548 creator A5030298591 @default.
• W4210757548 creator A5038140282 @default.
• W4210757548 creator A5064503714 @default.
• W4210757548 creator A5071418027 @default.
• W4210757548 creator A5081488291 @default.
• W4210757548 date "2022-02-17" @default.
• W4210757548 modified "2023-10-18" @default.
• W4210757548 title "Postoperative nonsteroidal anti‐inflammatory drugs in relation to recurrence, survival and anastomotic leakage after surgery for colorectal cancer" @default.
• W4210757548 cites W1970738595 @default.
• W4210757548 cites W1979400227 @default.
• W4210757548 cites W1984242781 @default.
• W4210757548 cites W1998459267 @default.
• W4210757548 cites W2010818945 @default.
• W4210757548 cites W2016564725 @default.
• W4210757548 cites W2027698993 @default.
• W4210757548 cites W2027798981 @default.
• W4210757548 cites W2032701488 @default.
• W4210757548 cites W2047819833 @default.
• W4210757548 cites W2077544314 @default.
• W4210757548 cites W2101249156 @default.
• W4210757548 cites W2184736686 @default.
• W4210757548 cites W2256846658 @default.
• W4210757548 cites W2268416834 @default.
• W4210757548 cites W2280178886 @default.
• W4210757548 cites W2539595513 @default.
• W4210757548 cites W2576536258 @default.
• W4210757548 cites W2599076725 @default.
• W4210757548 cites W2619053950 @default.
• W4210757548 cites W2626751126 @default.
• W4210757548 cites W2724506944 @default.
• W4210757548 cites W2736557952 @default.
• W4210757548 cites W2752946091 @default.
• W4210757548 cites W2762467945 @default.
• W4210757548 cites W2782725859 @default.
• W4210757548 cites W2790381016 @default.
• W4210757548 cites W2791897467 @default.
• W4210757548 cites W2807941368 @default.
• W4210757548 cites W2896379731 @default.
• W4210757548 cites W2902299007 @default.
• W4210757548 cites W2903264513 @default.
• W4210757548 cites W2960187349 @default.
• W4210757548 cites W2979642192 @default.
• W4210757548 cites W3005930418 @default.
• W4210757548 cites W3044447021 @default.
• W4210757548 cites W3127013244 @default.
• W4210757548 cites W3130473551 @default.
• W4210757548 cites W3134484374 @default.
• W4210757548 cites W4210757548 @default.
• W4210757548 cites W4211229530 @default.
• W4210757548 cites W4229941561 @default.
• W4210757548 cites W4248429808 @default.
• W4210757548 cites W3092729598 @default.
• W4210757548 doi "https://doi.org/10.1111/codi.16074" @default.
• W4210757548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35108455" @default.
• W4210757548 hasPublicationYear "2022" @default.
• W4210757548 type Work @default.
• W4210757548 citedByCount "7" @default.
• W4210757548 countsByYear W42107575482022 @default.
• W4210757548 countsByYear W42107575482023 @default.
• W4210757548 crossrefType "journal-article" @default.
• W4210757548 hasAuthorship W4210757548A5028320904 @default.
• W4210757548 hasAuthorship W4210757548A5030298591 @default.
• W4210757548 hasAuthorship W4210757548A5038140282 @default.
• W4210757548 hasAuthorship W4210757548A5064503714 @default.
• W4210757548 hasAuthorship W4210757548A5071418027 @default.
• W4210757548 hasAuthorship W4210757548A5081488291 @default.
• W4210757548 hasBestOaLocation W42107575481 @default.
• W4210757548 hasConcept C121608353 @default.
• W4210757548 hasConcept C126322002 @default.
• W4210757548 hasConcept C141071460 @default.
• W4210757548 hasConcept C156957248 @default.
• W4210757548 hasConcept C167135981 @default.
• W4210757548 hasConcept C201903717 @default.
• W4210757548 hasConcept C207103383 @default.
• W4210757548 hasConcept C2778484676 @default.
• W4210757548 hasConcept C2780120127 @default.
• W4210757548 hasConcept C44249647 @default.
• W4210757548 hasConcept C50382708 @default.
• W4210757548 hasConcept C523026621 @default.
• W4210757548 hasConcept C526805850 @default.
• W4210757548 hasConcept C71924100 @default.
• W4210757548 hasConcept C77350462 @default.
• W4210757548 hasConcept C90924648 @default.
• W4210757548 hasConceptScore W4210757548C121608353 @default.
• W4210757548 hasConceptScore W4210757548C126322002 @default.
• W4210757548 hasConceptScore W4210757548C141071460 @default.
• W4210757548 hasConceptScore W4210757548C156957248 @default.
• W4210757548 hasConceptScore W4210757548C167135981 @default.
• W4210757548 hasConceptScore W4210757548C201903717 @default.
• W4210757548 hasConceptScore W4210757548C207103383 @default.
• W4210757548 hasConceptScore W4210757548C2778484676 @default.
• W4210757548 hasConceptScore W4210757548C2780120127 @default.
• W4210757548 hasConceptScore W4210757548C44249647 @default.
• W4210757548 hasConceptScore W4210757548C50382708 @default.
• W4210757548 hasConceptScore W4210757548C523026621 @default.

• next