Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210761857> ?p ?o ?g. }
- W4210761857 endingPage "301" @default.
- W4210761857 startingPage "301" @default.
- W4210761857 abstract "The fastidious nature of Brachyspira hyodysenteriae limits an accurate in vitro pre-screening of conventionally used antibiotics and other candidate alternative antimicrobials. This results in a non-judicious use of antibiotics, leading to an exponential increase of the antibiotic resistance issue and a slowdown in the research for new molecules that might stop this serious phenomenon. In this study we tested four antibiotics (tylosin, lincomycin, doxycycline, and tiamulin) and medium-chain fatty acids (MCFA; hexanoic, octanoic, decanoic, and dodecanoic acid) against an Italian field strain of B. hyodysenteriae and the ATCC 27164 strain as reference. We determined the minimal inhibitory concentrations of these substances, underlining the multidrug resistance pattern of the field strain and, on the contrary, a consistent and stable inhibitory effect of the tested MCFA against both strains. Then, sub-inhibitory concentrations of antibiotics and MCFA were examined in modulating a panel of B. hyodysenteriae virulence genes (tlyA, tlyB, bhlp16, bhlp29.7, and bhmp39f). Results of gene expression analysis were variable, with up- and downregulations not properly correlated with particular substances or target genes. Decanoic and dodecanoic acid with their direct and indirect antimicrobial property were the most effective among MCFA, suggesting them as good candidates for subsequent in vivo trials." @default.
- W4210761857 created "2022-02-08" @default.
- W4210761857 creator A5001187594 @default.
- W4210761857 creator A5054477784 @default.
- W4210761857 creator A5056031093 @default.
- W4210761857 creator A5083779260 @default.
- W4210761857 date "2022-01-27" @default.
- W4210761857 modified "2023-10-14" @default.
- W4210761857 title "Dual Antimicrobial Effect of Medium-Chain Fatty Acids against an Italian Multidrug Resistant Brachyspira hyodysenteriae Strain" @default.
- W4210761857 cites W1570063046 @default.
- W4210761857 cites W1793924104 @default.
- W4210761857 cites W1821420942 @default.
- W4210761857 cites W1957354265 @default.
- W4210761857 cites W1978152264 @default.
- W4210761857 cites W1982105343 @default.
- W4210761857 cites W1989238853 @default.
- W4210761857 cites W1993998970 @default.
- W4210761857 cites W2007512489 @default.
- W4210761857 cites W2020767440 @default.
- W4210761857 cites W2029840302 @default.
- W4210761857 cites W2030001334 @default.
- W4210761857 cites W2037473914 @default.
- W4210761857 cites W2044671177 @default.
- W4210761857 cites W2049099399 @default.
- W4210761857 cites W2059738917 @default.
- W4210761857 cites W2073759966 @default.
- W4210761857 cites W2074564032 @default.
- W4210761857 cites W2091249255 @default.
- W4210761857 cites W2106427558 @default.
- W4210761857 cites W2107277218 @default.
- W4210761857 cites W2111527827 @default.
- W4210761857 cites W2112079485 @default.
- W4210761857 cites W2122939835 @default.
- W4210761857 cites W2136072677 @default.
- W4210761857 cites W2145552413 @default.
- W4210761857 cites W2146881320 @default.
- W4210761857 cites W2164485104 @default.
- W4210761857 cites W2165453126 @default.
- W4210761857 cites W2192080449 @default.
- W4210761857 cites W2337934269 @default.
- W4210761857 cites W2417083261 @default.
- W4210761857 cites W2419304383 @default.
- W4210761857 cites W2460332768 @default.
- W4210761857 cites W2518803807 @default.
- W4210761857 cites W2621194172 @default.
- W4210761857 cites W2772167507 @default.
- W4210761857 cites W2796092742 @default.
- W4210761857 cites W2897080883 @default.
- W4210761857 cites W2904276508 @default.
- W4210761857 cites W2993850489 @default.
- W4210761857 cites W2998904818 @default.
- W4210761857 cites W3011953604 @default.
- W4210761857 cites W3020321104 @default.
- W4210761857 cites W3030151603 @default.
- W4210761857 cites W3033796013 @default.
- W4210761857 cites W3044029771 @default.
- W4210761857 doi "https://doi.org/10.3390/microorganisms10020301" @default.
- W4210761857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35208756" @default.
- W4210761857 hasPublicationYear "2022" @default.
- W4210761857 type Work @default.
- W4210761857 citedByCount "5" @default.
- W4210761857 countsByYear W42107618572022 @default.
- W4210761857 countsByYear W42107618572023 @default.
- W4210761857 crossrefType "journal-article" @default.
- W4210761857 hasAuthorship W4210761857A5001187594 @default.
- W4210761857 hasAuthorship W4210761857A5054477784 @default.
- W4210761857 hasAuthorship W4210761857A5056031093 @default.
- W4210761857 hasAuthorship W4210761857A5083779260 @default.
- W4210761857 hasBestOaLocation W42107618571 @default.
- W4210761857 hasConcept C2775876089 @default.
- W4210761857 hasConcept C2777179404 @default.
- W4210761857 hasConcept C2777241463 @default.
- W4210761857 hasConcept C4937899 @default.
- W4210761857 hasConcept C501593827 @default.
- W4210761857 hasConcept C86803240 @default.
- W4210761857 hasConcept C89423630 @default.
- W4210761857 hasConcept C94665300 @default.
- W4210761857 hasConceptScore W4210761857C2775876089 @default.
- W4210761857 hasConceptScore W4210761857C2777179404 @default.
- W4210761857 hasConceptScore W4210761857C2777241463 @default.
- W4210761857 hasConceptScore W4210761857C4937899 @default.
- W4210761857 hasConceptScore W4210761857C501593827 @default.
- W4210761857 hasConceptScore W4210761857C86803240 @default.
- W4210761857 hasConceptScore W4210761857C89423630 @default.
- W4210761857 hasConceptScore W4210761857C94665300 @default.
- W4210761857 hasIssue "2" @default.
- W4210761857 hasLocation W42107618571 @default.
- W4210761857 hasLocation W42107618572 @default.
- W4210761857 hasLocation W42107618573 @default.
- W4210761857 hasLocation W42107618574 @default.
- W4210761857 hasLocation W42107618575 @default.
- W4210761857 hasOpenAccess W4210761857 @default.
- W4210761857 hasPrimaryLocation W42107618571 @default.
- W4210761857 hasRelatedWork W2318509744 @default.
- W4210761857 hasRelatedWork W2349061690 @default.
- W4210761857 hasRelatedWork W2791876444 @default.
- W4210761857 hasRelatedWork W2802146129 @default.
- W4210761857 hasRelatedWork W2907284219 @default.