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• W4210762912 abstract "ABSTRACT Polycystins are conserved mechanosensitive channels whose mutations lead to the common human renal disorder autosomal dominant polycystic kidney disease (ADPKD). Previously, we discovered that the plasma membrane-localized fission yeast polycystin homolog Pkd2p is an essential protein required for cytokinesis; however, its role remains unclear. Here, we isolated a novel temperature-sensitive pkd2 mutant, pkd2-B42. Among the strong growth defects of this mutant, the most striking was that many mutant cells often lost a significant portion of their volume in just 5 min followed by a gradual recovery, a process that we termed ‘deflation’. Unlike cell lysis, deflation did not result in plasma membrane rupture and occurred independently of cell cycle progression. The tip extension of pkd2-B42 cells was 80% slower than that of wild-type cells, and their turgor pressure was 50% lower. Both pkd2-B42 and the hypomorphic depletion mutant pkd2-81KD partially rescued mutants of the septation initiation network (SIN), a yeast Hippo-related signaling pathway, by preventing cell lysis, enhancing septum formation and doubling the number of Sid2p and Mob1p molecules at the spindle pole bodies. We conclude that Pkd2p promotes cell size expansion during interphase by regulating turgor pressure and antagonizes the SIN during cytokinesis. This article has an associated First Person interview with the first author of the paper." @default.
• W4210762912 created "2022-02-08" @default.
• W4210762912 creator A5005467111 @default.
• W4210762912 creator A5042082198 @default.
• W4210762912 creator A5047985331 @default.
• W4210762912 creator A5074219312 @default.
• W4210762912 creator A5082476504 @default.
• W4210762912 creator A5082547313 @default.
• W4210762912 date "2022-02-15" @default.
• W4210762912 modified "2023-10-01" @default.
• W4210762912 title "Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway" @default.
• W4210762912 cites W1492104840 @default.
• W4210762912 cites W1572472250 @default.
• W4210762912 cites W1963498090 @default.
• W4210762912 cites W1965271485 @default.
• W4210762912 cites W1969971205 @default.
• W4210762912 cites W1971197630 @default.
• W4210762912 cites W1972311512 @default.
• W4210762912 cites W1974469080 @default.
• W4210762912 cites W1981171373 @default.
• W4210762912 cites W1983410565 @default.
• W4210762912 cites W1985768637 @default.
• W4210762912 cites W1989759690 @default.
• W4210762912 cites W1994802218 @default.
• W4210762912 cites W1997487958 @default.
• W4210762912 cites W1998176022 @default.
• W4210762912 cites W2005026678 @default.
• W4210762912 cites W2006111579 @default.
• W4210762912 cites W2010227280 @default.
• W4210762912 cites W2013199563 @default.
• W4210762912 cites W2013430161 @default.
• W4210762912 cites W2014264816 @default.
• W4210762912 cites W2014276510 @default.
• W4210762912 cites W2023532525 @default.
• W4210762912 cites W2037766522 @default.
• W4210762912 cites W2043042730 @default.
• W4210762912 cites W2046593460 @default.
• W4210762912 cites W2048032817 @default.
• W4210762912 cites W2052029354 @default.
• W4210762912 cites W2056747087 @default.
• W4210762912 cites W2057150869 @default.
• W4210762912 cites W2060074423 @default.
• W4210762912 cites W2070517400 @default.
• W4210762912 cites W2081659168 @default.
• W4210762912 cites W2085308794 @default.
• W4210762912 cites W2091060631 @default.
• W4210762912 cites W2095869636 @default.
• W4210762912 cites W2097665654 @default.
• W4210762912 cites W2100073779 @default.
• W4210762912 cites W2100465045 @default.
• W4210762912 cites W2101222380 @default.
• W4210762912 cites W2106008443 @default.
• W4210762912 cites W2108667280 @default.
• W4210762912 cites W2109123964 @default.
• W4210762912 cites W2109689528 @default.
• W4210762912 cites W2110123230 @default.
• W4210762912 cites W2112591804 @default.
• W4210762912 cites W2117659967 @default.
• W4210762912 cites W2121734455 @default.
• W4210762912 cites W2127303707 @default.
• W4210762912 cites W2128126813 @default.
• W4210762912 cites W2131938193 @default.
• W4210762912 cites W2133610066 @default.
• W4210762912 cites W2133918532 @default.
• W4210762912 cites W2136955958 @default.
• W4210762912 cites W2141595533 @default.
• W4210762912 cites W2142224436 @default.
• W4210762912 cites W2146420402 @default.
• W4210762912 cites W2148056172 @default.
• W4210762912 cites W2152548624 @default.
• W4210762912 cites W2152560257 @default.
• W4210762912 cites W2153785134 @default.
• W4210762912 cites W2155249865 @default.
• W4210762912 cites W2158081530 @default.
• W4210762912 cites W2159376228 @default.
• W4210762912 cites W2161695152 @default.
• W4210762912 cites W2164429360 @default.
• W4210762912 cites W2188979715 @default.
• W4210762912 cites W2194986544 @default.
• W4210762912 cites W2215082513 @default.
• W4210762912 cites W2234646024 @default.
• W4210762912 cites W2405928886 @default.
• W4210762912 cites W2465930762 @default.
• W4210762912 cites W2768079938 @default.
• W4210762912 cites W2796763039 @default.
• W4210762912 cites W2887272845 @default.
• W4210762912 cites W2887884663 @default.
• W4210762912 cites W2896842033 @default.
• W4210762912 cites W2920797766 @default.
• W4210762912 cites W2946006621 @default.
• W4210762912 cites W2987483766 @default.
• W4210762912 cites W3014393039 @default.
• W4210762912 cites W3017153080 @default.
• W4210762912 cites W3019753637 @default.
• W4210762912 cites W3105246569 @default.
• W4210762912 cites W3158865878 @default.
• W4210762912 cites W3160225587 @default.
• W4210762912 cites W4231007273 @default.
• W4210762912 cites W4319290968 @default.
• W4210762912 doi "https://doi.org/10.1242/jcs.259046" @default.

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