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- W4210769397 abstract "Abstract The kinetics of amyloid beta turnover within human brain is still poorly understood. We previously found a dramatic decline in the turnover of Aβ peptides in normal aging. It was not known if brain interstitial fluid/cerebrospinal fluid (ISF/CSF) fluid exchange, CSF turnover, blood-brain barrier function or proteolysis were affected by aging or the presence of β amyloid plaques. Here, we describe a non-steady state physiological model developed to decouple CSF fluid transport from other processes. Kinetic parameters were estimated using: (1) MRI-derived brain volumes, (2) stable isotope labeling kinetics (SILK) of amyloid-β peptide (Aβ), and (3) lumbar CSF Aβ concentration during SILK. Here we show that changes in blood-brain barrier transport and/or proteolysis were largely responsible for the age-related decline in Aβ turnover rates. CSF-based clearance declined modestly in normal aging but became increasingly important due to the slowing of other processes. The magnitude of CSF-based clearance was also lower than that due to blood-brain barrier function plus proteolysis. These results suggest important roles for blood-brain barrier transport and proteolytic degradation of Aβ in the development Alzheimer’s Disease in humans." @default.
- W4210769397 created "2022-02-08" @default.
- W4210769397 creator A5029941147 @default.
- W4210769397 creator A5047976243 @default.
- W4210769397 creator A5051059746 @default.
- W4210769397 creator A5051999483 @default.
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- W4210769397 date "2022-01-27" @default.
- W4210769397 modified "2023-10-14" @default.
- W4210769397 title "Importance of CSF-based Aβ clearance with age in humans increases with declining efficacy of blood-brain barrier/proteolytic pathways" @default.
- W4210769397 cites W139300322 @default.
- W4210769397 cites W1480236339 @default.
- W4210769397 cites W1613370405 @default.
- W4210769397 cites W1776336091 @default.
- W4210769397 cites W1846188986 @default.
- W4210769397 cites W1919284595 @default.
- W4210769397 cites W1963683269 @default.
- W4210769397 cites W1968740432 @default.
- W4210769397 cites W1969329146 @default.
- W4210769397 cites W1969652816 @default.
- W4210769397 cites W1977128117 @default.
- W4210769397 cites W1977593264 @default.
- W4210769397 cites W1985323612 @default.
- W4210769397 cites W2000706612 @default.
- W4210769397 cites W2005860242 @default.
- W4210769397 cites W2019675628 @default.
- W4210769397 cites W2030325989 @default.
- W4210769397 cites W2033061580 @default.
- W4210769397 cites W2035300851 @default.
- W4210769397 cites W2038228524 @default.
- W4210769397 cites W2040456615 @default.
- W4210769397 cites W2045454808 @default.
- W4210769397 cites W2046952010 @default.
- W4210769397 cites W2059264110 @default.
- W4210769397 cites W2063236931 @default.
- W4210769397 cites W2081273944 @default.
- W4210769397 cites W2083579475 @default.
- W4210769397 cites W2088151512 @default.
- W4210769397 cites W2088714934 @default.
- W4210769397 cites W2090097368 @default.
- W4210769397 cites W2090592195 @default.
- W4210769397 cites W2097674782 @default.
- W4210769397 cites W2099390250 @default.
- W4210769397 cites W2112856433 @default.
- W4210769397 cites W2120575449 @default.
- W4210769397 cites W2120740638 @default.
- W4210769397 cites W2125136428 @default.
- W4210769397 cites W2125368074 @default.
- W4210769397 cites W2127690375 @default.
- W4210769397 cites W2129379145 @default.
- W4210769397 cites W2133541776 @default.
- W4210769397 cites W2136321415 @default.
- W4210769397 cites W2137273166 @default.
- W4210769397 cites W2143795852 @default.
- W4210769397 cites W2152734721 @default.
- W4210769397 cites W2161420960 @default.
- W4210769397 cites W2163408319 @default.
- W4210769397 cites W2163958074 @default.
- W4210769397 cites W2164765564 @default.
- W4210769397 cites W2165503155 @default.
- W4210769397 cites W2166601114 @default.
- W4210769397 cites W2166613874 @default.
- W4210769397 cites W2167183660 @default.
- W4210769397 cites W2170656454 @default.
- W4210769397 cites W2187829723 @default.
- W4210769397 cites W2296326130 @default.
- W4210769397 cites W2309633614 @default.
- W4210769397 cites W2319697373 @default.
- W4210769397 cites W2419455538 @default.
- W4210769397 cites W2560579910 @default.
- W4210769397 cites W2566617049 @default.
- W4210769397 cites W2588581682 @default.
- W4210769397 cites W2592552360 @default.
- W4210769397 cites W2619381903 @default.
- W4210769397 cites W2620935551 @default.
- W4210769397 cites W2746870493 @default.
- W4210769397 cites W2747884879 @default.
- W4210769397 cites W2750130602 @default.
- W4210769397 cites W2751474624 @default.
- W4210769397 cites W2766474578 @default.
- W4210769397 cites W2773346142 @default.
- W4210769397 cites W2775928354 @default.
- W4210769397 cites W2788532030 @default.
- W4210769397 cites W2789872951 @default.
- W4210769397 cites W2796079430 @default.
- W4210769397 cites W2801863964 @default.
- W4210769397 cites W2804841099 @default.
- W4210769397 cites W2807029080 @default.
- W4210769397 cites W2892061688 @default.
- W4210769397 cites W2898255378 @default.
- W4210769397 cites W2913773261 @default.
- W4210769397 cites W3025374083 @default.
- W4210769397 cites W3033935909 @default.
- W4210769397 cites W3044217620 @default.
- W4210769397 cites W3103673483 @default.
- W4210769397 cites W3134957406 @default.
- W4210769397 doi "https://doi.org/10.1038/s42003-022-03037-0" @default.
- W4210769397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35087179" @default.
- W4210769397 hasPublicationYear "2022" @default.
- W4210769397 type Work @default.