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- W4210771152 abstract "Newly developed chemical methods have been applied to study ADP-ribosyl transferase reactions in intact cells following DNA damage. The intracellular levels of NAD and protein-bound monomeric and polymeric ADP-ribose residues were measured in cultured human cells following UV irradiation and in cultured mouse cells treated with N-methyl-N’-nitro-N-nitrosoguanidine (MNNG). UV irradiation of cells caused a rapid increase in the levels of poly(ADP-ribose). Individual molecules of the polymer are present only transiently and the overall rate of conversion of NAD to poly(ADP-ribose) is proportional to the cellular content of DNA strand breaks. Treatment of cells with MNNG also causes a rapid increase in the levels of both monomers and polymers of ADP-ribose. Non-toxic levels of members of two different classes of ADP-ribosyl transferase inhibitors prevent recovery of cell division following treatment of C3H10T1 /2 cells with MNNG, while closely related compounds that are not inhibitory have no effect. These studies demonstrate that DNA damage results in a rapid perturbation of ADP-ribose metabolism and suggest that ADP-ribosyl transferase activity is necessary for cellular recovery from DNA damage." @default.
- W4210771152 created "2022-02-08" @default.
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- W4210771152 date "2020-07-26" @default.
- W4210771152 modified "2023-09-30" @default.
- W4210771152 title "Mono- and Poly(ADP-ribose) Metabolism Following DNA Damage" @default.
- W4210771152 doi "https://doi.org/10.1201/9781003079491-19" @default.
- W4210771152 hasPublicationYear "2020" @default.
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