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- W4210798634 abstract "Embryo fragmentation represents a phenomenon generally characterized by the presence of membrane-bound extracellular cytoplasm into the perivitelline space. Recent evidence supports the cellular and molecular heterogeneity of embryo fragments. In this narrative review, we described the different embryo fragment-like cellular structures in their morphology, molecular content, and supposed function and have reported the proposed theories on their origin over the years. We identified articles related to characterization of embryo fragmentation with a specific literature search string. The occurrence of embryo fragmentation has been related to various mechanisms, of which the most studied are apoptotic cell death, membrane compartmentalization of altered DNA, cytoskeletal disorders, and vesicle formation. These phenomena are thought to result in the extrusion of entire blastomeres, release of apoptotic bodies and other vesicles, and micronuclei formation. Different patterns of fragmentation may have different etiologies and effects on embryo competence. Removal of fragments from the embryo before embryo transfer with the aim to improve implantation potential should be reconsidered on the basis of the present observations." @default.
- W4210798634 created "2022-02-08" @default.
- W4210798634 creator A5007584093 @default.
- W4210798634 creator A5017392671 @default.
- W4210798634 creator A5045042141 @default.
- W4210798634 creator A5073215211 @default.
- W4210798634 creator A5073892131 @default.
- W4210798634 date "2022-01-25" @default.
- W4210798634 modified "2023-10-16" @default.
- W4210798634 title "Cellular and Molecular Nature of Fragmentation of Human Embryos" @default.
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