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• W4210800432 startingPage "47" @default.
• W4210800432 abstract "The multistep translational science behind new drugs comprehends the entire process through laboratory, clinical, and community observations turned into health interventions. The development of new drug options from discovering targets and leading compounds in basic research for implementing therapeutic guidelines contributes to the emergence of health policies essential for infection control. This review updates the translational research in the scenario of the most common non-viral sexually transmitted infection (STI), trichomoniasis. Paradoxically to its high occurrence, it is considered neglected since notification is not mandatory. It turns into a stable disease with health complications, and receives little emphasis from public health programs to control STI. Although related to curable STIs, the current drugs, metronidazole and tinidazole, present therapeutic failures. The need for new options to treat trichomoniasis is established by basic research studies and patents revealing novel synthetic compounds and natural products presenting anti-Trichomonas vaginalis activities, mainly based on in vitro findings. Clinical trials are still focused on new routes of administration for conventional drugs. In addition, nanotechnology approaches are in their infancy, shedding light on potential possibilities for creating more effective, targeted, and safe delivery systems. Overall, the novel proposed approaches need, in addition to pharmaceutical development and efficacy assessments, to ensure that the quality requirements for their use as medicines are met. It is essential to overcome these issues to cross the “Death Valley” of drug discovery and to advance in the translational science criteria in the trichomoniasis drug development field." @default.
• W4210800432 created "2022-02-08" @default.
• W4210800432 creator A5020363917 @default.
• W4210800432 creator A5027412822 @default.
• W4210800432 creator A5046207663 @default.
• W4210800432 creator A5055484696 @default.
• W4210800432 creator A5068855331 @default.
• W4210800432 date "2022-01-29" @default.
• W4210800432 modified "2023-09-26" @default.
• W4210800432 title "Novel Treatment Approaches to Combat Trichomoniasis, a Neglected and Sexually Transmitted Infection Caused by Trichomonas vaginalis: Translational Perspectives" @default.
• W4210800432 cites W1597858695 @default.
• W4210800432 cites W1943168996 @default.
• W4210800432 cites W1947125990 @default.
• W4210800432 cites W1947668386 @default.
• W4210800432 cites W1957242060 @default.
• W4210800432 cites W1964506433 @default.
• W4210800432 cites W1966707547 @default.
• W4210800432 cites W1974075673 @default.
• W4210800432 cites W1974131041 @default.
• W4210800432 cites W1977905204 @default.
• W4210800432 cites W1979439261 @default.
• W4210800432 cites W1980462681 @default.
• W4210800432 cites W1984229242 @default.
• W4210800432 cites W1994627440 @default.
• W4210800432 cites W2002727005 @default.
• W4210800432 cites W2009292648 @default.
• W4210800432 cites W2014096824 @default.
• W4210800432 cites W2015828091 @default.
• W4210800432 cites W2033494253 @default.
• W4210800432 cites W2035898942 @default.
• W4210800432 cites W2041800910 @default.
• W4210800432 cites W2048794344 @default.
• W4210800432 cites W2058082432 @default.
• W4210800432 cites W2060272137 @default.
• W4210800432 cites W2068076121 @default.
• W4210800432 cites W2069108701 @default.
• W4210800432 cites W2069266885 @default.
• W4210800432 cites W2072731790 @default.
• W4210800432 cites W2077448072 @default.
• W4210800432 cites W2080920767 @default.
• W4210800432 cites W2084017410 @default.
• W4210800432 cites W2088226047 @default.
• W4210800432 cites W2089199361 @default.
• W4210800432 cites W2092212913 @default.
• W4210800432 cites W2103580630 @default.
• W4210800432 cites W2131315067 @default.
• W4210800432 cites W2135769723 @default.
• W4210800432 cites W2153529285 @default.
• W4210800432 cites W2187995112 @default.
• W4210800432 cites W2213749173 @default.
• W4210800432 cites W2251934274 @default.
• W4210800432 cites W2265889136 @default.
• W4210800432 cites W2298340155 @default.
• W4210800432 cites W2300704577 @default.
• W4210800432 cites W2313361335 @default.
• W4210800432 cites W2328948344 @default.
• W4210800432 cites W2345082447 @default.
• W4210800432 cites W2513450278 @default.
• W4210800432 cites W2524866294 @default.
• W4210800432 cites W2545030312 @default.
• W4210800432 cites W2547463189 @default.
• W4210800432 cites W2552197898 @default.
• W4210800432 cites W2554328878 @default.
• W4210800432 cites W2580891590 @default.
• W4210800432 cites W2591329288 @default.
• W4210800432 cites W2592216494 @default.
• W4210800432 cites W2605088273 @default.
• W4210800432 cites W2620283047 @default.
• W4210800432 cites W2752812832 @default.
• W4210800432 cites W2755181067 @default.
• W4210800432 cites W2756423660 @default.
• W4210800432 cites W2779431579 @default.
• W4210800432 cites W2779518696 @default.
• W4210800432 cites W2787297984 @default.
• W4210800432 cites W2792126313 @default.
• W4210800432 cites W2792916938 @default.
• W4210800432 cites W2793286278 @default.
• W4210800432 cites W2796155092 @default.
• W4210800432 cites W2802452463 @default.
• W4210800432 cites W2887631041 @default.
• W4210800432 cites W2887964279 @default.
• W4210800432 cites W2890662649 @default.
• W4210800432 cites W2895441253 @default.
• W4210800432 cites W2898005124 @default.
• W4210800432 cites W2901234277 @default.
• W4210800432 cites W2903767141 @default.
• W4210800432 cites W2905500959 @default.
• W4210800432 cites W2905961248 @default.
• W4210800432 cites W2906362926 @default.
• W4210800432 cites W2908989434 @default.
• W4210800432 cites W2926259352 @default.
• W4210800432 cites W2943597774 @default.
• W4210800432 cites W2963541510 @default.
• W4210800432 cites W2982344625 @default.
• W4210800432 cites W2989108935 @default.
• W4210800432 cites W2994766728 @default.
• W4210800432 cites W2999689663 @default.
• W4210800432 cites W3008607175 @default.

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