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• W4210804018 abstract "The amacrine neurons in the mammalian retina comprise a large variety of cell types with distinct properties and functions that serve to integrate and modulate signals presented to output neurons. The majority of them use either glycine or GABA as inhibitory neurotransmitters and express the glycine transporter 1 (GlyT1) or glutamic acid decarboxylase (GAD67) and GABA transporters (GAT1 and GAT3), as a glycinergic or GABAergic marker respectively. We report here a novel subpopulation of amacrine neurons expressing both, GABAergic and glycinergic markers, in retinas from wild-type C57BL/6J mice and two transgenic lines. In retinal sections from the transgenic line expressing eGFP under the control of the glycine transporter 2, eGFP expression was exclusively found in cell bodies and dendrites of inhibitory amacrine neurons, identified for their immunoreactivity to syntaxin 1A. All of the glycinergic and a large portion of the GABAergic amacrine neurons contained eGFP; of these, 8-10% of GlyT1 positive neurons were also labeled either with GAD67, GAT1 or GAT3. These findings were confirmed in retinas from a wild-type and a mouse line expressing eGFP under the GAD67 promoter and two different anti-GlyT1 antibodies, showing the presence of a subpopulation with a dual phenotype. Moreover, eGFP-positive dendrites on both mouse lines were found juxtaposed to GlyR subunits and the scaffold protein gephyrin in several areas of the inner plexiform layer, demonstrating the glycinergic character of these neurons. This dual phenotype was also demonstrated in primary retina cultures, in which isolated neurons were positive for GlyT1 and GAD67 or GAT1/3. Altogether, these data provide compelling evidence of a subpopulation of dual inhibitory, glycinergic/GABAergic amacrine neurons. The co-release of both neurotransmitters may serve to strengthen the inhibition on ganglion cells under synaptic hyperexcitability." @default.
• W4210804018 created "2022-02-08" @default.
• W4210804018 creator A5004974996 @default.
• W4210804018 creator A5009602373 @default.
• W4210804018 creator A5015831158 @default.
• W4210804018 creator A5040661972 @default.
• W4210804018 creator A5061334871 @default.
• W4210804018 creator A5069029279 @default.
• W4210804018 creator A5082566777 @default.
• W4210804018 date "2022-01-01" @default.
• W4210804018 modified "2023-09-27" @default.
• W4210804018 title "Identification of Amacrine Neurons with a Glycinergic and Gabaergic Phenotype in the Mouse Retina" @default.
• W4210804018 cites W1482769507 @default.
• W4210804018 cites W1488048016 @default.
• W4210804018 cites W1516906688 @default.
• W4210804018 cites W1525811169 @default.
• W4210804018 cites W1540473838 @default.
• W4210804018 cites W1549420378 @default.
• W4210804018 cites W1759675687 @default.
• W4210804018 cites W1768795272 @default.
• W4210804018 cites W1770930219 @default.
• W4210804018 cites W1852646540 @default.
• W4210804018 cites W1908164157 @default.
• W4210804018 cites W1924525922 @default.
• W4210804018 cites W1965305290 @default.
• W4210804018 cites W1965956049 @default.
• W4210804018 cites W1966187441 @default.
• W4210804018 cites W1968490089 @default.
• W4210804018 cites W1972342888 @default.
• W4210804018 cites W1977199897 @default.
• W4210804018 cites W1979820522 @default.
• W4210804018 cites W1982256785 @default.
• W4210804018 cites W1985097707 @default.
• W4210804018 cites W1985814681 @default.
• W4210804018 cites W1986058895 @default.
• W4210804018 cites W1988838201 @default.
• W4210804018 cites W1989524951 @default.
• W4210804018 cites W1990816409 @default.
• W4210804018 cites W1992896202 @default.
• W4210804018 cites W1995569557 @default.
• W4210804018 cites W1997447156 @default.
• W4210804018 cites W1999490342 @default.
• W4210804018 cites W1999612489 @default.
• W4210804018 cites W2002191155 @default.
• W4210804018 cites W2002598925 @default.
• W4210804018 cites W2012708985 @default.
• W4210804018 cites W2016873833 @default.
• W4210804018 cites W2022198005 @default.
• W4210804018 cites W2028437994 @default.
• W4210804018 cites W2034302571 @default.
• W4210804018 cites W2034845337 @default.
• W4210804018 cites W2036239753 @default.
• W4210804018 cites W2037820041 @default.
• W4210804018 cites W2042070545 @default.
• W4210804018 cites W2043000322 @default.
• W4210804018 cites W2043057314 @default.
• W4210804018 cites W2049879893 @default.
• W4210804018 cites W2055623289 @default.
• W4210804018 cites W2060943169 @default.
• W4210804018 cites W2061068333 @default.
• W4210804018 cites W2067744991 @default.
• W4210804018 cites W2070424298 @default.
• W4210804018 cites W2077853373 @default.
• W4210804018 cites W2078647525 @default.
• W4210804018 cites W2080937698 @default.
• W4210804018 cites W2081678712 @default.
• W4210804018 cites W2086262272 @default.
• W4210804018 cites W2090596818 @default.
• W4210804018 cites W2090625429 @default.
• W4210804018 cites W2092150344 @default.
• W4210804018 cites W2093347794 @default.
• W4210804018 cites W2093753588 @default.
• W4210804018 cites W2096089101 @default.
• W4210804018 cites W2099153171 @default.
• W4210804018 cites W2101630258 @default.
• W4210804018 cites W2109298408 @default.
• W4210804018 cites W2115487032 @default.
• W4210804018 cites W2119051861 @default.
• W4210804018 cites W2135911939 @default.
• W4210804018 cites W2145566545 @default.
• W4210804018 cites W2147137091 @default.
• W4210804018 cites W2154776297 @default.
• W4210804018 cites W2156269367 @default.
• W4210804018 cites W2158404383 @default.
• W4210804018 cites W2159050782 @default.
• W4210804018 cites W2160214073 @default.
• W4210804018 cites W2165664498 @default.
• W4210804018 cites W2165917097 @default.
• W4210804018 cites W2167058119 @default.
• W4210804018 cites W2191536914 @default.
• W4210804018 cites W2257198069 @default.
• W4210804018 cites W2300106671 @default.
• W4210804018 cites W2329913331 @default.
• W4210804018 cites W2538373155 @default.
• W4210804018 cites W2602548552 @default.
• W4210804018 cites W2755462365 @default.
• W4210804018 cites W2806150294 @default.
• W4210804018 cites W2899688632 @default.
• W4210804018 cites W2947421158 @default.
• W4210804018 cites W98874919 @default.

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