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- W4210808343 abstract "The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the third occurrence of a highly pathogenic coronavirus in the human population since 2003. As the death toll surpasses 5 million globally and economic losses continue, designing drugs that could curtail infection and disease progression is critical. In the US, three highly effective Food and Drug Administration (FDA)-authorized vaccines are currently available, and Remdesivir is approved for the treatment of hospitalized patients. However, moderate vaccination rates and the sustained evolution of new viral variants necessitate the ongoing search for new antivirals. Several viral proteins have been prioritized as SARS-CoV-2 antiviral drug targets, among them the papain-like protease (PLpro) and the main protease (Mpro). Inhibition of these proteases would target viral replication, viral maturation, and suppression of host innate immune responses. Knowledge of inhibitors and assays for viruses were quickly adopted for SARS-CoV-2 protease research. Potential candidates have been identified to show inhibitory effects against PLpro and Mpro, both in biochemical assays and viral replication in cells. These results encourage further optimizations to improve prophylactic and therapeutic efficacy. In this review, we examine the latest developments of potential small-molecule inhibitors and peptide inhibitors for PLpro and Mpro, and how structural biology greatly facilitates this process." @default.
- W4210808343 created "2022-02-08" @default.
- W4210808343 creator A5000997540 @default.
- W4210808343 creator A5059032419 @default.
- W4210808343 creator A5059500596 @default.
- W4210808343 creator A5074359093 @default.
- W4210808343 creator A5079883319 @default.
- W4210808343 creator A5090859327 @default.
- W4210808343 date "2022-02-03" @default.
- W4210808343 modified "2023-10-10" @default.
- W4210808343 title "Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development" @default.
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