FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210822887> ?p ?o ?g. }

• W4210822887 endingPage "4527" @default.
• W4210822887 startingPage "4517" @default.
• W4210822887 abstract "Chronic kidney disease (CKD) in clinical is defined as a gradual loss of kidney function for more than 3 months. The pathologic course of CKD is characterized by extensive renal fibrosis; thus, preventing renal fibrosis is vital for the treatment of CKD. It has been reported that microRNA (miR)-374a-5p was under-expressed in renal venous blood samples from patients with CKD. In addition, it exhibited anti-apoptotic effects in renal tissues suggesting that miR-374a-5p may play an important role in CKD. However, it is not clear whether miR-374a-5p could be delivered to renal cells by exosomes and exerts anti-renal fibrosis effects. To mimic renal fibrosis in vitro, human renal tubular epithelial cell lines (HK-2 cells) were treated by transforming growth factor-β (TGF-β) 1. Reverse transcription-quantitative polymerase-chain reaction (RT-qPCR) or Western blot was carried out to evaluate the mechanism by which miR-374a-5p regulated the development of renal fibrosis. Next, exosomes were isolated using with ultracentrifugation method, and the relationship between miR-374a-5p and MAPK6 was evaluated using dual-Luciferase a reporter assay system. The results indicated TGF-β1 significantly down-regulated the expression of miR-374a-5p in HK-2 cells and miR-374a-5p agomir remarkably inhibited the progression of fibrosis in vitro. In addition, exosomal miR-374a-5p could be internalized by HK-2 cells and obviously enhanced the level of miR-374a-5p in HK-2 cells. Furthermore, exosomal miR-374a-5p prevented the progression of renal fibrosis in vivo by regulating MAPK6/MK5/YAP axis. In conclusion, exosomal miR-374a-5p inhibited the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis." @default.
• W4210822887 created "2022-02-09" @default.
• W4210822887 creator A5021085140 @default.
• W4210822887 creator A5030611214 @default.
• W4210822887 creator A5036362323 @default.
• W4210822887 creator A5064293395 @default.
• W4210822887 creator A5071738759 @default.
• W4210822887 date "2022-02-01" @default.
• W4210822887 modified "2023-09-30" @default.
• W4210822887 title "Exosomes from miR-374a-5p-modified mesenchymal stem cells inhibit the progression of renal fibrosis by regulating MAPK6/MK5/YAP axis" @default.
• W4210822887 cites W1579314656 @default.
• W4210822887 cites W1934417607 @default.
• W4210822887 cites W1972936386 @default.
• W4210822887 cites W2107008239 @default.
• W4210822887 cites W2401390149 @default.
• W4210822887 cites W2411149830 @default.
• W4210822887 cites W2516370793 @default.
• W4210822887 cites W2517894941 @default.
• W4210822887 cites W2559986308 @default.
• W4210822887 cites W2576066242 @default.
• W4210822887 cites W2580826825 @default.
• W4210822887 cites W2587850954 @default.
• W4210822887 cites W2763288540 @default.
• W4210822887 cites W2767549258 @default.
• W4210822887 cites W2801400869 @default.
• W4210822887 cites W2809783743 @default.
• W4210822887 cites W2891340777 @default.
• W4210822887 cites W2900597665 @default.
• W4210822887 cites W2911048719 @default.
• W4210822887 cites W2917790483 @default.
• W4210822887 cites W2939780639 @default.
• W4210822887 cites W2946645851 @default.
• W4210822887 cites W2955452369 @default.
• W4210822887 cites W2968587936 @default.
• W4210822887 cites W2975701363 @default.
• W4210822887 cites W2978713536 @default.
• W4210822887 cites W2979130888 @default.
• W4210822887 cites W2992413241 @default.
• W4210822887 cites W3015859480 @default.
• W4210822887 cites W3023806539 @default.
• W4210822887 cites W3045089985 @default.
• W4210822887 cites W3104014715 @default.
• W4210822887 cites W3196990328 @default.
• W4210822887 cites W3201728835 @default.
• W4210822887 cites W3203164466 @default.
• W4210822887 cites W3204176264 @default.
• W4210822887 cites W3206558545 @default.
• W4210822887 cites W3209944607 @default.
• W4210822887 cites W3210626977 @default.
• W4210822887 cites W3212377491 @default.
• W4210822887 cites W3213439271 @default.
• W4210822887 cites W3214349254 @default.
• W4210822887 cites W4200164305 @default.
• W4210822887 cites W4200191278 @default.
• W4210822887 cites W4229508150 @default.
• W4210822887 doi "https://doi.org/10.1080/21655979.2022.2033465" @default.
• W4210822887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35137672" @default.
• W4210822887 hasPublicationYear "2022" @default.
• W4210822887 type Work @default.
• W4210822887 citedByCount "9" @default.
• W4210822887 countsByYear W42108228872022 @default.
• W4210822887 countsByYear W42108228872023 @default.
• W4210822887 crossrefType "journal-article" @default.
• W4210822887 hasAuthorship W4210822887A5021085140 @default.
• W4210822887 hasAuthorship W4210822887A5030611214 @default.
• W4210822887 hasAuthorship W4210822887A5036362323 @default.
• W4210822887 hasAuthorship W4210822887A5064293395 @default.
• W4210822887 hasAuthorship W4210822887A5071738759 @default.
• W4210822887 hasBestOaLocation W42108228871 @default.
• W4210822887 hasConcept C104317684 @default.
• W4210822887 hasConcept C126322002 @default.
• W4210822887 hasConcept C138798377 @default.
• W4210822887 hasConcept C145059251 @default.
• W4210822887 hasConcept C201750760 @default.
• W4210822887 hasConcept C20518536 @default.
• W4210822887 hasConcept C2778653478 @default.
• W4210822887 hasConcept C2780091579 @default.
• W4210822887 hasConcept C2780559512 @default.
• W4210822887 hasConcept C2781261824 @default.
• W4210822887 hasConcept C28328180 @default.
• W4210822887 hasConcept C502942594 @default.
• W4210822887 hasConcept C55493867 @default.
• W4210822887 hasConcept C71924100 @default.
• W4210822887 hasConcept C86803240 @default.
• W4210822887 hasConcept C95444343 @default.
• W4210822887 hasConceptScore W4210822887C104317684 @default.
• W4210822887 hasConceptScore W4210822887C126322002 @default.
• W4210822887 hasConceptScore W4210822887C138798377 @default.
• W4210822887 hasConceptScore W4210822887C145059251 @default.
• W4210822887 hasConceptScore W4210822887C201750760 @default.
• W4210822887 hasConceptScore W4210822887C20518536 @default.
• W4210822887 hasConceptScore W4210822887C2778653478 @default.
• W4210822887 hasConceptScore W4210822887C2780091579 @default.
• W4210822887 hasConceptScore W4210822887C2780559512 @default.
• W4210822887 hasConceptScore W4210822887C2781261824 @default.
• W4210822887 hasConceptScore W4210822887C28328180 @default.
• W4210822887 hasConceptScore W4210822887C502942594 @default.
• W4210822887 hasConceptScore W4210822887C55493867 @default.

• next