FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210823897> ?p ?o ?g. }

• W4210823897 abstract "Abstract Motivation Epitope-based molecular mimicry occurs when an antibody cross-reacts with two different antigens due to structural and chemical similarities. Molecular mimicry between proteins from two viruses can lead to beneficial cross-protection when the antibodies produced by exposure to one also react with the other. On the other hand, mimicry between a protein from a pathogen and a human protein can lead to auto-immune disorders if the antibodies resulting from exposure to the virus end up interacting with host proteins. While cross-protection can suggest the possible reuse of vaccines developed for other pathogens, cross-reaction with host proteins may explain side effects. There are no computational tools available to date for a large-scale search of antibody cross-reactivity. Results We present a comprehensive Epitope-based Molecular Mimicry Search ( EMoMiS ) pipeline for computational molecular mimicry searches. EMoMiS , when applied to the SARS-CoV-2 Spike protein, identified eight examples of molecular mimicry with viral and human proteins. These findings provide possible explanations for (a) differential severity of COVID-19 caused by cross-protection due to prior vaccinations and/or exposure to other viruses, and (b) commonly seen COVID-19 side effects such as thrombocytopenia and thrombophilia. Our findings are supported by previously reported research but need validation with laboratory experiments. The developed pipeline is generic and can be applied to find mimicry for novel pathogens. It has applications in improving vaccine design. Availability The developed Epitope-based Molecular Mimicry Search Pipeline ( EMoMiS ) is available from https://biorg.cs.fiu.edu/emomis/ . Contact giri@cs.fiu.edu" @default.
• W4210823897 created "2022-02-09" @default.
• W4210823897 creator A5013657335 @default.
• W4210823897 creator A5015279499 @default.
• W4210823897 creator A5024069342 @default.
• W4210823897 creator A5030005377 @default.
• W4210823897 creator A5037360822 @default.
• W4210823897 creator A5045295085 @default.
• W4210823897 creator A5060905723 @default.
• W4210823897 creator A5068890173 @default.
• W4210823897 creator A5069453041 @default.
• W4210823897 creator A5071186045 @default.
• W4210823897 creator A5084012065 @default.
• W4210823897 date "2022-02-07" @default.
• W4210823897 modified "2023-10-15" @default.
• W4210823897 title "EMoMiS: A Pipeline for Epitope-based Molecular Mimicry Search in Protein Structures with Applications to SARS-CoV-2" @default.
• W4210823897 cites W1543980776 @default.
• W4210823897 cites W1829437510 @default.
• W4210823897 cites W1996423252 @default.
• W4210823897 cites W1999114258 @default.
• W4210823897 cites W2018470704 @default.
• W4210823897 cites W2019355614 @default.
• W4210823897 cites W2065897299 @default.
• W4210823897 cites W2073189639 @default.
• W4210823897 cites W2084534408 @default.
• W4210823897 cites W2086463570 @default.
• W4210823897 cites W2102245393 @default.
• W4210823897 cites W2110505462 @default.
• W4210823897 cites W2114850508 @default.
• W4210823897 cites W2128196947 @default.
• W4210823897 cites W2130479394 @default.
• W4210823897 cites W2137879329 @default.
• W4210823897 cites W2142056945 @default.
• W4210823897 cites W2146939455 @default.
• W4210823897 cites W2154865008 @default.
• W4210823897 cites W2155645351 @default.
• W4210823897 cites W2158714788 @default.
• W4210823897 cites W2266901554 @default.
• W4210823897 cites W2326896496 @default.
• W4210823897 cites W2613409207 @default.
• W4210823897 cites W2775376782 @default.
• W4210823897 cites W2789199387 @default.
• W4210823897 cites W2801537519 @default.
• W4210823897 cites W2898389621 @default.
• W4210823897 cites W2966620487 @default.
• W4210823897 cites W2990689232 @default.
• W4210823897 cites W2992752586 @default.
• W4210823897 cites W3000099904 @default.
• W4210823897 cites W3016404849 @default.
• W4210823897 cites W3016492430 @default.
• W4210823897 cites W3018759429 @default.
• W4210823897 cites W3020409391 @default.
• W4210823897 cites W3022788428 @default.
• W4210823897 cites W3038674692 @default.
• W4210823897 cites W3047998398 @default.
• W4210823897 cites W3048945192 @default.
• W4210823897 cites W3083908457 @default.
• W4210823897 cites W3089321178 @default.
• W4210823897 cites W3096976925 @default.
• W4210823897 cites W3103498104 @default.
• W4210823897 cites W3115059693 @default.
• W4210823897 cites W3120974536 @default.
• W4210823897 cites W3129414840 @default.
• W4210823897 cites W3129715843 @default.
• W4210823897 cites W3131414937 @default.
• W4210823897 cites W3136437538 @default.
• W4210823897 cites W3138740255 @default.
• W4210823897 cites W3160811128 @default.
• W4210823897 cites W3173081728 @default.
• W4210823897 cites W3173163233 @default.
• W4210823897 cites W3174731125 @default.
• W4210823897 cites W3177828909 @default.
• W4210823897 cites W3191459258 @default.
• W4210823897 cites W3192545069 @default.
• W4210823897 cites W3198119820 @default.
• W4210823897 cites W3215596827 @default.
• W4210823897 cites W4210637293 @default.
• W4210823897 cites W4255594044 @default.
• W4210823897 cites W4293003482 @default.
• W4210823897 doi "https://doi.org/10.1101/2022.02.05.479274" @default.
• W4210823897 hasPublicationYear "2022" @default.
• W4210823897 type Work @default.
• W4210823897 citedByCount "7" @default.
• W4210823897 countsByYear W42108238972021 @default.
• W4210823897 countsByYear W42108238972022 @default.
• W4210823897 countsByYear W42108238972023 @default.
• W4210823897 crossrefType "posted-content" @default.
• W4210823897 hasAuthorship W4210823897A5013657335 @default.
• W4210823897 hasAuthorship W4210823897A5015279499 @default.
• W4210823897 hasAuthorship W4210823897A5024069342 @default.
• W4210823897 hasAuthorship W4210823897A5030005377 @default.
• W4210823897 hasAuthorship W4210823897A5037360822 @default.
• W4210823897 hasAuthorship W4210823897A5045295085 @default.
• W4210823897 hasAuthorship W4210823897A5060905723 @default.
• W4210823897 hasAuthorship W4210823897A5068890173 @default.
• W4210823897 hasAuthorship W4210823897A5069453041 @default.
• W4210823897 hasAuthorship W4210823897A5071186045 @default.
• W4210823897 hasAuthorship W4210823897A5084012065 @default.
• W4210823897 hasBestOaLocation W42108238971 @default.
• W4210823897 hasConcept C159047783 @default.

• next