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- W4210827906 abstract "Pulsatile RhoA dynamics underlie a wide range of cell and tissue behaviors. The circuits that produce these dynamics in different cells share common architectures based on fast positive and delayed negative feedback through F-actin, but they can produce very different spatiotemporal patterns of RhoA activity. However, the underlying causes of this variation remain poorly understood. Here we asked how this variation could arise through modulation of actin network dynamics downstream of active RhoA in early Caenorhabditis elegans embryos. We find that perturbing two RhoA effectors-formin and anillin-induce transitions from nonrecurrent focal pulses to either large noisy oscillatory pulses (formin depletion) or noisy oscillatory waves (anillin depletion). In both cases these transitions could be explained by changes in local F-actin levels and depletion dynamics, leading to changes in spatial and temporal patterns of RhoA inhibition. However, the underlying mechanisms for F-actin depletion are distinct, with different dependencies on myosin II activity. Thus, modulating actomyosin network dynamics could shape the spatiotemporal dynamics of RhoA activity for different physiological or morphogenetic functions." @default.
- W4210827906 created "2022-02-09" @default.
- W4210827906 creator A5013007051 @default.
- W4210827906 creator A5021203238 @default.
- W4210827906 creator A5029620798 @default.
- W4210827906 creator A5068671796 @default.
- W4210827906 date "2022-05-15" @default.
- W4210827906 modified "2023-10-10" @default.
- W4210827906 title "Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in <i>Caenorhabditis elegans</i> zygotes" @default.
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- W4210827906 doi "https://doi.org/10.1091/mbc.e21-11-0542" @default.
- W4210827906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35138935" @default.
- W4210827906 hasPublicationYear "2022" @default.
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