FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210830913> ?p ?o ?g. }

• W4210830913 abstract "Hagfish are an excellent model species in which to draw inferences on the evolution of transport systems in early vertebrates owing to their basal position in vertebrate phylogeny. Glucose is a ubiquitous cellular energy source that is transported into cells via two classes of carrier proteins: sodium-glucose-linked transporters (Sglt; Slc5a) and glucose transporters (Glut; Slc2a). Although previous pharmacological evidence has suggested the presence of both sodium-dependent and -independent transport mechanisms in the hagfish, the molecular identities were heretofore unconfirmed. We have identified and phylogenetically characterized both a Slc5a1-like and Slc2a-like gene in the Pacific hagfish (Eptatretus stoutii), the latter sharing common ancestry with other glucose-transporting isoforms of the Slc2a family. To assess the potential postprandial regulation of these glucose transporters, we examined the abundance and localization of these transporters with qPCR and immunohistochemistry alongside functional studies using radiolabeled d-[14C]glucose. The effects of glucose or insulin injection on glucose transport rate and transporter expression were also examined to determine their potential role(s) in the regulation of intestinal glucose carrier proteins. Feeding prompted an increase in glucose uptake across the hindgut at both 0.5 mM (∼84%) and 1 mM (∼183%) concentrations. Concomitant increases were observed in hindgut Slc5a1 protein expression. These effects were not observed following either of glucose or insulin injection, indicating these postprandial factors are not the driving force for transporter regulation over this timeframe. We conclude that Pacific hagfish utilize evolutionarily conserved mechanisms of glucose uptake and so represent a useful model to understand early-vertebrate evolution of glucose uptake and regulation." @default.
• W4210830913 created "2022-02-09" @default.
• W4210830913 creator A5009016406 @default.
• W4210830913 creator A5044830104 @default.
• W4210830913 creator A5050977143 @default.
• W4210830913 creator A5051058138 @default.
• W4210830913 creator A5065856517 @default.
• W4210830913 creator A5066037376 @default.
• W4210830913 date "2022-02-09" @default.
• W4210830913 modified "2023-09-27" @default.
• W4210830913 title "Molecular identification and post-prandial regulation of glucose carrier proteins in the hindgut of Pacific hagfish, Eptatretus stoutii" @default.
• W4210830913 cites W1914628154 @default.
• W4210830913 cites W1963957860 @default.
• W4210830913 cites W1977878035 @default.
• W4210830913 cites W1980799022 @default.
• W4210830913 cites W1999349827 @default.
• W4210830913 cites W2010765166 @default.
• W4210830913 cites W2028302194 @default.
• W4210830913 cites W2030324194 @default.
• W4210830913 cites W2031476702 @default.
• W4210830913 cites W2040465012 @default.
• W4210830913 cites W2053795827 @default.
• W4210830913 cites W2062526841 @default.
• W4210830913 cites W2074231493 @default.
• W4210830913 cites W2077888771 @default.
• W4210830913 cites W2078374645 @default.
• W4210830913 cites W2092568641 @default.
• W4210830913 cites W2127898622 @default.
• W4210830913 cites W2132926880 @default.
• W4210830913 cites W2133469996 @default.
• W4210830913 cites W2134948484 @default.
• W4210830913 cites W2136409488 @default.
• W4210830913 cites W2149531726 @default.
• W4210830913 cites W2157656299 @default.
• W4210830913 cites W2159957100 @default.
• W4210830913 cites W2163627198 @default.
• W4210830913 cites W2167023561 @default.
• W4210830913 cites W2263517846 @default.
• W4210830913 cites W2309487596 @default.
• W4210830913 cites W2559191318 @default.
• W4210830913 cites W2572578157 @default.
• W4210830913 cites W2580706476 @default.
• W4210830913 cites W2736323022 @default.
• W4210830913 cites W2767372646 @default.
• W4210830913 cites W2773056470 @default.
• W4210830913 cites W2902940703 @default.
• W4210830913 cites W2908516728 @default.
• W4210830913 cites W2908650979 @default.
• W4210830913 cites W2935376038 @default.
• W4210830913 cites W2960312428 @default.
• W4210830913 cites W2973211785 @default.
• W4210830913 cites W2980851030 @default.
• W4210830913 cites W3013879228 @default.
• W4210830913 cites W3031469457 @default.
• W4210830913 cites W4237424488 @default.
• W4210830913 cites W4245203016 @default.
• W4210830913 cites W4361867816 @default.
• W4210830913 doi "https://doi.org/10.1152/ajpregu.00003.2022" @default.
• W4210830913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35138949" @default.
• W4210830913 hasPublicationYear "2022" @default.
• W4210830913 type Work @default.
• W4210830913 citedByCount "0" @default.
• W4210830913 crossrefType "journal-article" @default.
• W4210830913 hasAuthorship W4210830913A5009016406 @default.
• W4210830913 hasAuthorship W4210830913A5044830104 @default.
• W4210830913 hasAuthorship W4210830913A5050977143 @default.
• W4210830913 hasAuthorship W4210830913A5051058138 @default.
• W4210830913 hasAuthorship W4210830913A5065856517 @default.
• W4210830913 hasAuthorship W4210830913A5066037376 @default.
• W4210830913 hasConcept C104317684 @default.
• W4210830913 hasConcept C126322002 @default.
• W4210830913 hasConcept C134018914 @default.
• W4210830913 hasConcept C149011108 @default.
• W4210830913 hasConcept C150149183 @default.
• W4210830913 hasConcept C161573976 @default.
• W4210830913 hasConcept C173758957 @default.
• W4210830913 hasConcept C18903297 @default.
• W4210830913 hasConcept C2776942755 @default.
• W4210830913 hasConcept C2777810479 @default.
• W4210830913 hasConcept C2777866211 @default.
• W4210830913 hasConcept C2778199505 @default.
• W4210830913 hasConcept C2778961482 @default.
• W4210830913 hasConcept C2779306644 @default.
• W4210830913 hasConcept C55493867 @default.
• W4210830913 hasConcept C71924100 @default.
• W4210830913 hasConcept C86803240 @default.
• W4210830913 hasConcept C95444343 @default.
• W4210830913 hasConceptScore W4210830913C104317684 @default.
• W4210830913 hasConceptScore W4210830913C126322002 @default.
• W4210830913 hasConceptScore W4210830913C134018914 @default.
• W4210830913 hasConceptScore W4210830913C149011108 @default.
• W4210830913 hasConceptScore W4210830913C150149183 @default.
• W4210830913 hasConceptScore W4210830913C161573976 @default.
• W4210830913 hasConceptScore W4210830913C173758957 @default.
• W4210830913 hasConceptScore W4210830913C18903297 @default.
• W4210830913 hasConceptScore W4210830913C2776942755 @default.
• W4210830913 hasConceptScore W4210830913C2777810479 @default.
• W4210830913 hasConceptScore W4210830913C2777866211 @default.
• W4210830913 hasConceptScore W4210830913C2778199505 @default.
• W4210830913 hasConceptScore W4210830913C2778961482 @default.

• next