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- W4210834259 abstract "Alzheimer's disease (AD) pathology is characterized by loss of memory cognitive and behavioral deterioration. One of the hallmarks of AD is amyloid β (Aβ) plaques in the brain that consists of Aβ oligomers and fibrils. It is accepted that oligomers, particularly dimers, are toxic species that are produced extracellularly and intracellularly in membranes. It is believed that the disruption of membranes by polymorphic Aβ oligomers is the key for the pathology of AD. This is a first study that investigate the effect of polymorphic α-helix/random coil and fibril-like Aβ dimers on 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membrane. It has been found that the DOPC membrane promotes Aβ1-42 fibril-like dimers and impedes Aβ1-42 α-helix/random coil dimers. The N-termini domains within Aβ1-42 dimers play a role in Aβ aggregation in membrane milieus. In addition, the aromatic π-π interactions (involving residues F19 and F20 in Aβ1-42 ) are the driving forces for the hydrophobic interactions that initiate the primary nucleation of polymorphic Aβ1-42 dimers within DOPC membrane. Finally, the DOPC bilayer membrane thickness is locally decreased, and it is disrupted by an embedded distinct Aβ1-42 dimer, due to relatively large contacts between Aβ1-42 monomers and the DOPC membrane. This study reveals insights into the molecular mechanisms by which polymorphic early-stage Aβ1-42 dimers have distinct impacts on DOPC membrane." @default.
- W4210834259 created "2022-02-09" @default.
- W4210834259 creator A5027274925 @default.
- W4210834259 creator A5049627179 @default.
- W4210834259 date "2022-04-09" @default.
- W4210834259 modified "2023-10-14" @default.
- W4210834259 title "Molecular insights into the primary nucleation of polymorphic amyloid β dimers in <scp>DOPC</scp> lipid bilayer membrane" @default.
- W4210834259 cites W1031578623 @default.
- W4210834259 cites W1455259219 @default.
- W4210834259 cites W1967838681 @default.
- W4210834259 cites W1971511188 @default.
- W4210834259 cites W1976499671 @default.
- W4210834259 cites W1978498560 @default.
- W4210834259 cites W1980825524 @default.
- W4210834259 cites W1984890358 @default.
- W4210834259 cites W1986276470 @default.
- W4210834259 cites W1987503846 @default.
- W4210834259 cites W1991794210 @default.
- W4210834259 cites W1993368030 @default.
- W4210834259 cites W2005092840 @default.
- W4210834259 cites W2007236469 @default.
- W4210834259 cites W2007593295 @default.
- W4210834259 cites W2026714067 @default.
- W4210834259 cites W2026981923 @default.
- W4210834259 cites W2028872675 @default.
- W4210834259 cites W2031868460 @default.
- W4210834259 cites W2035687084 @default.
- W4210834259 cites W2035906765 @default.
- W4210834259 cites W2039701693 @default.
- W4210834259 cites W2039706105 @default.
- W4210834259 cites W2041638382 @default.
- W4210834259 cites W2052038479 @default.
- W4210834259 cites W2052586778 @default.
- W4210834259 cites W2057477511 @default.
- W4210834259 cites W2060914703 @default.
- W4210834259 cites W2061531041 @default.
- W4210834259 cites W2063679630 @default.
- W4210834259 cites W2067174909 @default.
- W4210834259 cites W2067464601 @default.
- W4210834259 cites W2074619433 @default.
- W4210834259 cites W2075537193 @default.
- W4210834259 cites W2075930760 @default.
- W4210834259 cites W2081693079 @default.
- W4210834259 cites W2083118855 @default.
- W4210834259 cites W2084219899 @default.
- W4210834259 cites W2091514612 @default.
- W4210834259 cites W2096336861 @default.
- W4210834259 cites W2099653907 @default.
- W4210834259 cites W2100817247 @default.
- W4210834259 cites W2103435773 @default.
- W4210834259 cites W2109727228 @default.
- W4210834259 cites W2118280241 @default.
- W4210834259 cites W2121963977 @default.
- W4210834259 cites W2122064497 @default.
- W4210834259 cites W2122294662 @default.
- W4210834259 cites W2128572087 @default.
- W4210834259 cites W2134909516 @default.
- W4210834259 cites W2135701488 @default.
- W4210834259 cites W2140323904 @default.
- W4210834259 cites W2149081087 @default.
- W4210834259 cites W2151747945 @default.
- W4210834259 cites W2156835500 @default.
- W4210834259 cites W2160557120 @default.
- W4210834259 cites W2163182995 @default.
- W4210834259 cites W2170323442 @default.
- W4210834259 cites W2171727742 @default.
- W4210834259 cites W2208177230 @default.
- W4210834259 cites W2252753559 @default.
- W4210834259 cites W2279613858 @default.
- W4210834259 cites W2313725855 @default.
- W4210834259 cites W2319217996 @default.
- W4210834259 cites W2333661022 @default.
- W4210834259 cites W2416362275 @default.
- W4210834259 cites W2509622579 @default.
- W4210834259 cites W2580969766 @default.
- W4210834259 cites W2583728075 @default.
- W4210834259 cites W2621904939 @default.
- W4210834259 cites W2745423572 @default.
- W4210834259 cites W2754103216 @default.
- W4210834259 cites W2787331998 @default.
- W4210834259 cites W2919571355 @default.
- W4210834259 cites W2919694858 @default.
- W4210834259 cites W2922582556 @default.
- W4210834259 cites W2935029136 @default.
- W4210834259 cites W2946968312 @default.
- W4210834259 cites W2952292812 @default.
- W4210834259 cites W2958817025 @default.
- W4210834259 cites W2973638461 @default.
- W4210834259 cites W3000429722 @default.
- W4210834259 cites W3039058174 @default.
- W4210834259 cites W3105586528 @default.
- W4210834259 cites W3200190491 @default.
- W4210834259 cites W3208106178 @default.
- W4210834259 cites W3209008080 @default.
- W4210834259 cites W4210834259 @default.
- W4210834259 cites W4256195416 @default.
- W4210834259 doi "https://doi.org/10.1002/pro.4283" @default.
- W4210834259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35129859" @default.
- W4210834259 hasPublicationYear "2022" @default.
- W4210834259 type Work @default.