FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210837069> ?p ?o ?g. }

• W4210837069 endingPage "e08887" @default.
• W4210837069 startingPage "e08887" @default.
• W4210837069 abstract "The IL-23/IL-17 axis plays an important role in the development of autoimmune diseases, but the mechanism regulating IL-23 production is mainly unknown. We investigated how TNFAIP3 and Sp1 affect IL-23 production by human macrophages after exposure to resiquimod, a TLR7/8 agonist. IL-23 production was significantly upregulated by resiquimod but only slightly by LPS (a TLR4 agonist). Interestingly, IL-23 levels were significantly attenuated after sequential stimulation with LPS and resiquimod, but IL-12p40 and IL-18 levels were not. TLR4-related factors induced by LPS may regulate IL-23 expression via TLR7/8 signaling. LPS significantly enhanced TNFAIP3 and IRAK-M levels but reduced Sp1 levels. After exposure to resiquimod, RNA interference of TNFAIP3 upregulated IL-23 significantly more than siRNA transfection of IRAK-M did. In contrast, knockdown of Sp1 by RNA interference significantly attenuated IL-23 production. Transfection with siRNA for TNFAIP3 enhanced IL-23 expression significantly. After stimulation with resiquimod, GW7647-an agonist for PPARα (an inducer of NADHP oxidase)-and siRNA for UCP2 (a negative regulator of mitochondrial ROS generation) enhanced TNFAIP3 and reduced IL-23. siRNA for p22phox and gp91phox slightly increased Sp1 levels. However, after exposure to resiquimod siRNA-mediated knockout of DUOX1/2 significantly enhanced Sp1 and IL-23 levels, and decreased TNFα-dependent COX-2 expression. Concomitantly, TNFAIP3 levels was attenuated by DUOX1/2 siRNA. TNFAIP3 and Sp1 levels are reciprocally regulated through ROS generation. In conclusion, after stimulation of the TLR7/8 signaling pathway IL-23 production in human macrophages is regulated negatively by TNFAIP3." @default.
• W4210837069 created "2022-02-09" @default.
• W4210837069 creator A5003484620 @default.
• W4210837069 creator A5004634738 @default.
• W4210837069 creator A5022375813 @default.
• W4210837069 creator A5033193145 @default.
• W4210837069 creator A5060694731 @default.
• W4210837069 creator A5078146127 @default.
• W4210837069 creator A5084769241 @default.
• W4210837069 date "2022-02-01" @default.
• W4210837069 modified "2023-09-26" @default.
• W4210837069 title "IL-23 production in human macrophages is regulated negatively by tumor necrosis factor α-induced protein 3 and positively by specificity protein 1 after stimulation of the toll-like receptor 7/8 signaling pathway" @default.
• W4210837069 cites W1604205457 @default.
• W4210837069 cites W1674844815 @default.
• W4210837069 cites W1697354033 @default.
• W4210837069 cites W1847326477 @default.
• W4210837069 cites W1889825709 @default.
• W4210837069 cites W1967947905 @default.
• W4210837069 cites W1976669514 @default.
• W4210837069 cites W1978642052 @default.
• W4210837069 cites W1979413396 @default.
• W4210837069 cites W1980987507 @default.
• W4210837069 cites W1982530463 @default.
• W4210837069 cites W1987145359 @default.
• W4210837069 cites W1988293824 @default.
• W4210837069 cites W1988942832 @default.
• W4210837069 cites W1997499807 @default.
• W4210837069 cites W1998423564 @default.
• W4210837069 cites W2006016083 @default.
• W4210837069 cites W2016146035 @default.
• W4210837069 cites W2016623432 @default.
• W4210837069 cites W2033158773 @default.
• W4210837069 cites W2034304797 @default.
• W4210837069 cites W2035315634 @default.
• W4210837069 cites W2035824519 @default.
• W4210837069 cites W2039649930 @default.
• W4210837069 cites W2052277212 @default.
• W4210837069 cites W2062555719 @default.
• W4210837069 cites W2068031486 @default.
• W4210837069 cites W2085890276 @default.
• W4210837069 cites W2090859543 @default.
• W4210837069 cites W2093139840 @default.
• W4210837069 cites W2101818249 @default.
• W4210837069 cites W2102552341 @default.
• W4210837069 cites W2106141541 @default.
• W4210837069 cites W2112163729 @default.
• W4210837069 cites W2116665363 @default.
• W4210837069 cites W2116672342 @default.
• W4210837069 cites W2119252289 @default.
• W4210837069 cites W2127704524 @default.
• W4210837069 cites W2129261650 @default.
• W4210837069 cites W2130970560 @default.
• W4210837069 cites W2151640567 @default.
• W4210837069 cites W2159913536 @default.
• W4210837069 cites W2167137743 @default.
• W4210837069 cites W2169015738 @default.
• W4210837069 cites W2209389920 @default.
• W4210837069 cites W2285852644 @default.
• W4210837069 cites W2291592387 @default.
• W4210837069 cites W2468150319 @default.
• W4210837069 cites W2612260650 @default.
• W4210837069 cites W2729009437 @default.
• W4210837069 cites W2740702941 @default.
• W4210837069 cites W2744265558 @default.
• W4210837069 cites W2751533718 @default.
• W4210837069 cites W2792553484 @default.
• W4210837069 cites W2887201177 @default.
• W4210837069 cites W2900436857 @default.
• W4210837069 cites W2939532730 @default.
• W4210837069 cites W2940149808 @default.
• W4210837069 cites W2991897615 @default.
• W4210837069 cites W606905299 @default.
• W4210837069 doi "https://doi.org/10.1016/j.heliyon.2022.e08887" @default.
• W4210837069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35198762" @default.
• W4210837069 hasPublicationYear "2022" @default.
• W4210837069 type Work @default.
• W4210837069 citedByCount "0" @default.
• W4210837069 crossrefType "journal-article" @default.
• W4210837069 hasAuthorship W4210837069A5003484620 @default.
• W4210837069 hasAuthorship W4210837069A5004634738 @default.
• W4210837069 hasAuthorship W4210837069A5022375813 @default.
• W4210837069 hasAuthorship W4210837069A5033193145 @default.
• W4210837069 hasAuthorship W4210837069A5060694731 @default.
• W4210837069 hasAuthorship W4210837069A5078146127 @default.
• W4210837069 hasAuthorship W4210837069A5084769241 @default.
• W4210837069 hasBestOaLocation W42108370691 @default.
• W4210837069 hasConcept C104317684 @default.
• W4210837069 hasConcept C127561419 @default.
• W4210837069 hasConcept C134018914 @default.
• W4210837069 hasConcept C136449434 @default.
• W4210837069 hasConcept C166703698 @default.
• W4210837069 hasConcept C170493617 @default.
• W4210837069 hasConcept C173396325 @default.
• W4210837069 hasConcept C17991360 @default.
• W4210837069 hasConcept C190283241 @default.
• W4210837069 hasConcept C22615655 @default.
• W4210837069 hasConcept C24998067 @default.
• W4210837069 hasConcept C2776070231 @default.

• next