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• W4210837701 startingPage "105292" @default.
• W4210837701 abstract "There has been recent success in prediction of the three-dimensional folded native structures of proteins, most famously by the AlphaFold Algorithm running on Google's/Alphabet's DeepMind computer. However, this largely involves machine learning of protein structures and is not a de novo protein structure prediction method for predicting three-dimensional structures from amino acid residue sequences. A de novo approach would be based almost entirely on general principles of energy and entropy that govern protein folding energetics, and importantly do so without the use of the amino acid sequences and structural features of other proteins. Most consider that problem as still unsolved even though it has occupied leading scientists for decades. Many consider that it remains one of the major outstanding issues in modern science. There is crucial continuing help from experimental findings on protein unfolding and refolding in the laboratory, but only to a limited extent because many researchers consider that the speed by which real proteins folds themselves, often from milliseconds to minutes, is itself still not fully understood. This is unfortunate, because a practical solution to the problem would probably have a major effect on personalized medicine, the pharmaceutical industry, biotechnology, and nanotechnology, including for example smaller tasks such as better modeling of flexible unfolded regions of the SARS-COV-2 spike glycoprotein when interacting with its cell receptor, antibodies, and therapeutic agents. Some important ideas from earlier studies are given before moving on to lessons from periodic and aperiodic crystals, and a possible role for quantum phenomena. The conclusion is that better computation of entropy should be the priority, though that is presented guardedly." @default.
• W4210837701 created "2022-02-09" @default.
• W4210837701 creator A5009453283 @default.
• W4210837701 date "2022-04-01" @default.
• W4210837701 modified "2023-09-29" @default.
• W4210837701 title "De novo protein folding on computers. Benefits and challenges" @default.
• W4210837701 cites W113688923 @default.
• W4210837701 cites W1164840235 @default.
• W4210837701 cites W1481590908 @default.
• W4210837701 cites W1496368635 @default.
• W4210837701 cites W1506812273 @default.
• W4210837701 cites W1512176015 @default.
• W4210837701 cites W1526480265 @default.
• W4210837701 cites W1546896179 @default.
• W4210837701 cites W1561293737 @default.
• W4210837701 cites W1606365631 @default.
• W4210837701 cites W1657648701 @default.
• W4210837701 cites W1658649599 @default.
• W4210837701 cites W179258906 @default.
• W4210837701 cites W1965838279 @default.
• W4210837701 cites W1966069639 @default.
• W4210837701 cites W1968879813 @default.
• W4210837701 cites W1969554454 @default.
• W4210837701 cites W1970043658 @default.
• W4210837701 cites W1971731200 @default.
• W4210837701 cites W1973473385 @default.
• W4210837701 cites W1974105492 @default.
• W4210837701 cites W1974621200 @default.
• W4210837701 cites W1976493332 @default.
• W4210837701 cites W1978683232 @default.
• W4210837701 cites W1979018519 @default.
• W4210837701 cites W1979847090 @default.
• W4210837701 cites W1985697934 @default.
• W4210837701 cites W1985821185 @default.
• W4210837701 cites W1987846414 @default.
• W4210837701 cites W1988397041 @default.
• W4210837701 cites W1989373400 @default.
• W4210837701 cites W1989447327 @default.
• W4210837701 cites W1990351127 @default.
• W4210837701 cites W1991498388 @default.
• W4210837701 cites W1992050258 @default.
• W4210837701 cites W1998347411 @default.
• W4210837701 cites W1999200626 @default.
• W4210837701 cites W2003343920 @default.
• W4210837701 cites W2006253061 @default.
• W4210837701 cites W2007577495 @default.
• W4210837701 cites W2009538777 @default.
• W4210837701 cites W2012020905 @default.
• W4210837701 cites W2014095962 @default.
• W4210837701 cites W2015265223 @default.
• W4210837701 cites W2016019576 @default.
• W4210837701 cites W2016936793 @default.
• W4210837701 cites W2019218232 @default.
• W4210837701 cites W2019447526 @default.
• W4210837701 cites W2022074454 @default.
• W4210837701 cites W2024132895 @default.
• W4210837701 cites W2024562806 @default.
• W4210837701 cites W2026101733 @default.
• W4210837701 cites W2027465657 @default.
• W4210837701 cites W2029851506 @default.
• W4210837701 cites W2032836888 @default.
• W4210837701 cites W2033417620 @default.
• W4210837701 cites W2041672614 @default.
• W4210837701 cites W2042612222 @default.
• W4210837701 cites W2043224212 @default.
• W4210837701 cites W2045777307 @default.
• W4210837701 cites W2049033408 @default.
• W4210837701 cites W2050799629 @default.
• W4210837701 cites W2052364252 @default.
• W4210837701 cites W2053111993 @default.
• W4210837701 cites W2053712028 @default.
• W4210837701 cites W2054407685 @default.
• W4210837701 cites W2055118532 @default.
• W4210837701 cites W2057980421 @default.
• W4210837701 cites W2064100411 @default.
• W4210837701 cites W2065159516 @default.
• W4210837701 cites W2068628419 @default.
• W4210837701 cites W2071075252 @default.
• W4210837701 cites W2072292331 @default.
• W4210837701 cites W2073739993 @default.
• W4210837701 cites W2075973109 @default.
• W4210837701 cites W2076713412 @default.
• W4210837701 cites W2077793638 @default.
• W4210837701 cites W2079193139 @default.
• W4210837701 cites W2083303808 @default.
• W4210837701 cites W2086034633 @default.
• W4210837701 cites W2087616070 @default.
• W4210837701 cites W2087729059 @default.
• W4210837701 cites W2089597488 @default.
• W4210837701 cites W2095450147 @default.
• W4210837701 cites W2099950967 @default.
• W4210837701 cites W2105903067 @default.
• W4210837701 cites W2112032866 @default.
• W4210837701 cites W2116441099 @default.
• W4210837701 cites W2119619424 @default.
• W4210837701 cites W2129020329 @default.
• W4210837701 cites W2139433006 @default.
• W4210837701 cites W2139774535 @default.

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