Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210840643> ?p ?o ?g. }
- W4210840643 endingPage "102261" @default.
- W4210840643 startingPage "102261" @default.
- W4210840643 abstract "Retinal pigment epithelium (RPE) dysfunction and atrophy occur in dry age-related macular degeneration (AMD), often leading to photoreceptor degeneration and vision loss. Accumulated oxidative stress during aging contributes to RPE dysfunction and degeneration. Here we show that the nuclear receptor REV-ERBα, a redox sensitive transcription factor, protects RPE from age-related degeneration and oxidative stress-induced damage. Genetic deficiency of REV-ERBα leads to accumulated oxidative stress, dysfunction and degeneration of RPE, and AMD-like ocular pathologies in aging mice. Loss of REV-ERBα exacerbates chemical-induced RPE damage, and pharmacological activation of REV-ERBα protects RPE from oxidative damage both in vivo and in vitro. REV-ERBα directly regulates transcription of nuclear factor erythroid 2-related factor 2 (NRF2) and its downstream antioxidant enzymes superoxide dismutase 1 (SOD1) and catalase to counter oxidative damage. Moreover, aged mice with RPE specific knockout of REV-ERBα also exhibit accumulated oxidative stress and fundus and RPE pathologies. Together, our results suggest that REV-ERBα is a novel intrinsic protector of the RPE against age-dependent oxidative stress and a new molecular target for developing potential therapies to treat age-related retinal degeneration." @default.
- W4210840643 created "2022-02-09" @default.
- W4210840643 creator A5000901768 @default.
- W4210840643 creator A5014799358 @default.
- W4210840643 creator A5022633411 @default.
- W4210840643 creator A5039842062 @default.
- W4210840643 creator A5042157374 @default.
- W4210840643 creator A5049233554 @default.
- W4210840643 creator A5058317587 @default.
- W4210840643 creator A5066500327 @default.
- W4210840643 creator A5070284401 @default.
- W4210840643 creator A5079275806 @default.
- W4210840643 date "2022-05-01" @default.
- W4210840643 modified "2023-09-30" @default.
- W4210840643 title "REV-ERBα regulates age-related and oxidative stress-induced degeneration in retinal pigment epithelium via NRF2" @default.
- W4210840643 cites W1450659139 @default.
- W4210840643 cites W1491374817 @default.
- W4210840643 cites W149224901 @default.
- W4210840643 cites W1499123544 @default.
- W4210840643 cites W1513413810 @default.
- W4210840643 cites W1566896910 @default.
- W4210840643 cites W1572091120 @default.
- W4210840643 cites W1603165537 @default.
- W4210840643 cites W1883306593 @default.
- W4210840643 cites W1898328784 @default.
- W4210840643 cites W1917315694 @default.
- W4210840643 cites W1965121033 @default.
- W4210840643 cites W1965546595 @default.
- W4210840643 cites W1975191711 @default.
- W4210840643 cites W1976263073 @default.
- W4210840643 cites W1984370593 @default.
- W4210840643 cites W1985105928 @default.
- W4210840643 cites W1990356462 @default.
- W4210840643 cites W1990630966 @default.
- W4210840643 cites W1998585946 @default.
- W4210840643 cites W2004170725 @default.
- W4210840643 cites W2008654807 @default.
- W4210840643 cites W2011072921 @default.
- W4210840643 cites W2017136158 @default.
- W4210840643 cites W2020391754 @default.
- W4210840643 cites W2021122140 @default.
- W4210840643 cites W2024991121 @default.
- W4210840643 cites W2031172417 @default.
- W4210840643 cites W2034940836 @default.
- W4210840643 cites W2036275511 @default.
- W4210840643 cites W2036419084 @default.
- W4210840643 cites W2043984428 @default.
- W4210840643 cites W2050672796 @default.
- W4210840643 cites W2056048638 @default.
- W4210840643 cites W2056337410 @default.
- W4210840643 cites W2061676785 @default.
- W4210840643 cites W2064170412 @default.
- W4210840643 cites W2064959471 @default.
- W4210840643 cites W2065711792 @default.
- W4210840643 cites W2066167805 @default.
- W4210840643 cites W2070698569 @default.
- W4210840643 cites W2077483301 @default.
- W4210840643 cites W2093505571 @default.
- W4210840643 cites W2095412797 @default.
- W4210840643 cites W2103752249 @default.
- W4210840643 cites W2104301336 @default.
- W4210840643 cites W2108995381 @default.
- W4210840643 cites W2115583552 @default.
- W4210840643 cites W2117917811 @default.
- W4210840643 cites W2123444655 @default.
- W4210840643 cites W2136899592 @default.
- W4210840643 cites W2143187099 @default.
- W4210840643 cites W2155314510 @default.
- W4210840643 cites W2207241376 @default.
- W4210840643 cites W2275799577 @default.
- W4210840643 cites W2322120913 @default.
- W4210840643 cites W2347205644 @default.
- W4210840643 cites W2507267592 @default.
- W4210840643 cites W2522090979 @default.
- W4210840643 cites W2560840508 @default.
- W4210840643 cites W2602573314 @default.
- W4210840643 cites W2753995352 @default.
- W4210840643 cites W2765087085 @default.
- W4210840643 cites W2793930217 @default.
- W4210840643 cites W2801800016 @default.
- W4210840643 cites W2892155992 @default.
- W4210840643 cites W2906111406 @default.
- W4210840643 cites W2937740908 @default.
- W4210840643 cites W2945672034 @default.
- W4210840643 cites W4234756901 @default.
- W4210840643 cites W4247214019 @default.
- W4210840643 cites W4256101427 @default.
- W4210840643 doi "https://doi.org/10.1016/j.redox.2022.102261" @default.
- W4210840643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35176707" @default.
- W4210840643 hasPublicationYear "2022" @default.
- W4210840643 type Work @default.
- W4210840643 citedByCount "9" @default.
- W4210840643 countsByYear W42108406432022 @default.
- W4210840643 countsByYear W42108406432023 @default.
- W4210840643 crossrefType "journal-article" @default.
- W4210840643 hasAuthorship W4210840643A5000901768 @default.
- W4210840643 hasAuthorship W4210840643A5014799358 @default.
- W4210840643 hasAuthorship W4210840643A5022633411 @default.