Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210848811> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W4210848811 endingPage "115093" @default.
- W4210848811 startingPage "115093" @default.
- W4210848811 abstract "Acalypha indica Linn (Euphorbiaceae), a popular traditional medicine, is an erect herb found throughout various parts of India. In Ayurveda, Acalypha indica was commonly used in asthma and allergy. However, no attempts were made in past to validate the antiasthmatic potential of Acalypha indica.The present study was aimed to assess the anti-asthmatic potential of ethanolic extracts of Acalypha indica leaves (EAIL) using various experimental animal models.EAIL was analyzed using different screening methods such as acetylcholine and histamine-induced contraction of goat tracheal chain, clonidine-induced catalepsy in mice, milk-induced leucocytosis and eosinophilia in mice, clonidine-induced mast cell degranulation in rats, passive paw anaphylaxis in rats, histamine-induced bronchoconstriction in guinea pigs, and ovalbumin (OVA)-induced histopathological alterations in mice.Data received in the present study showed that EAIL drastically antagonized acetylcholine and histamine-induced contraction of goat tracheal chain, suggesting its anticholinergic and antihistaminic activity respectively. The duration of immobility, produced by clonidine, was found to be decreased in mice which showed its H1 receptor blocking activity. In milk-induced leucocytosis and eosinophilia in mice, EAIL significantly reduced the number of leucocytes and eosinophils suggesting its adaptogenic and anti-allergic potential. Inhibition of clonidine-induced mast cell degranulation in rats displayed its mast cell stabilizing potential. Reduction of paw edema in passive paw anaphylaxis exhibited antianaphylactic activity of EAIL. Guinea pigs were protected from histamine-induced bronchoconstriction by EAIL which revealed its bronchodilator potential. Furthermore, the histopathological architecture of lung tissue was near to normal.Our results contribute towards validation of the traditional use of Acalypha indica in the treatment of asthma due to the presence of a wide range of phytoconstituents. Hence our investigation revealed that EAIL possessed strong antiasthmatic property by virtue of various mechanisms." @default.
- W4210848811 created "2022-02-09" @default.
- W4210848811 creator A5001004350 @default.
- W4210848811 creator A5056895098 @default.
- W4210848811 date "2022-05-01" @default.
- W4210848811 modified "2023-10-14" @default.
- W4210848811 title "Pharmacological screening of Acalypha indica L.: Possible role in the treatment of asthma" @default.
- W4210848811 cites W2003154020 @default.
- W4210848811 cites W2022277127 @default.
- W4210848811 cites W2040957219 @default.
- W4210848811 cites W2041321691 @default.
- W4210848811 cites W2044496940 @default.
- W4210848811 cites W2047577412 @default.
- W4210848811 cites W2073419937 @default.
- W4210848811 cites W2076877981 @default.
- W4210848811 cites W2078020718 @default.
- W4210848811 cites W2080417621 @default.
- W4210848811 cites W2084071295 @default.
- W4210848811 cites W2090724562 @default.
- W4210848811 cites W2119621206 @default.
- W4210848811 cites W2133359176 @default.
- W4210848811 cites W2137789711 @default.
- W4210848811 cites W2323426201 @default.
- W4210848811 cites W2333837063 @default.
- W4210848811 cites W2560690367 @default.
- W4210848811 cites W2580550072 @default.
- W4210848811 cites W4232687989 @default.
- W4210848811 doi "https://doi.org/10.1016/j.jep.2022.115093" @default.
- W4210848811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35149129" @default.
- W4210848811 hasPublicationYear "2022" @default.
- W4210848811 type Work @default.
- W4210848811 citedByCount "2" @default.
- W4210848811 countsByYear W42108488112023 @default.
- W4210848811 crossrefType "journal-article" @default.
- W4210848811 hasAuthorship W4210848811A5001004350 @default.
- W4210848811 hasAuthorship W4210848811A5056895098 @default.
- W4210848811 hasConcept C1122143 @default.
- W4210848811 hasConcept C126322002 @default.
- W4210848811 hasConcept C147483822 @default.
- W4210848811 hasConcept C170493617 @default.
- W4210848811 hasConcept C203014093 @default.
- W4210848811 hasConcept C207480886 @default.
- W4210848811 hasConcept C2775933838 @default.
- W4210848811 hasConcept C2776042228 @default.
- W4210848811 hasConcept C2776946954 @default.
- W4210848811 hasConcept C2777129736 @default.
- W4210848811 hasConcept C2778399450 @default.
- W4210848811 hasConcept C2779726688 @default.
- W4210848811 hasConcept C2780571441 @default.
- W4210848811 hasConcept C2780769369 @default.
- W4210848811 hasConcept C49802076 @default.
- W4210848811 hasConcept C556039675 @default.
- W4210848811 hasConcept C71924100 @default.
- W4210848811 hasConcept C98274493 @default.
- W4210848811 hasConceptScore W4210848811C1122143 @default.
- W4210848811 hasConceptScore W4210848811C126322002 @default.
- W4210848811 hasConceptScore W4210848811C147483822 @default.
- W4210848811 hasConceptScore W4210848811C170493617 @default.
- W4210848811 hasConceptScore W4210848811C203014093 @default.
- W4210848811 hasConceptScore W4210848811C207480886 @default.
- W4210848811 hasConceptScore W4210848811C2775933838 @default.
- W4210848811 hasConceptScore W4210848811C2776042228 @default.
- W4210848811 hasConceptScore W4210848811C2776946954 @default.
- W4210848811 hasConceptScore W4210848811C2777129736 @default.
- W4210848811 hasConceptScore W4210848811C2778399450 @default.
- W4210848811 hasConceptScore W4210848811C2779726688 @default.
- W4210848811 hasConceptScore W4210848811C2780571441 @default.
- W4210848811 hasConceptScore W4210848811C2780769369 @default.
- W4210848811 hasConceptScore W4210848811C49802076 @default.
- W4210848811 hasConceptScore W4210848811C556039675 @default.
- W4210848811 hasConceptScore W4210848811C71924100 @default.
- W4210848811 hasConceptScore W4210848811C98274493 @default.
- W4210848811 hasLocation W42108488111 @default.
- W4210848811 hasLocation W42108488112 @default.
- W4210848811 hasOpenAccess W4210848811 @default.
- W4210848811 hasPrimaryLocation W42108488111 @default.
- W4210848811 hasRelatedWork W1967213352 @default.
- W4210848811 hasRelatedWork W2012378759 @default.
- W4210848811 hasRelatedWork W2020986186 @default.
- W4210848811 hasRelatedWork W2039852465 @default.
- W4210848811 hasRelatedWork W2077706878 @default.
- W4210848811 hasRelatedWork W2094020747 @default.
- W4210848811 hasRelatedWork W2094403085 @default.
- W4210848811 hasRelatedWork W2146544010 @default.
- W4210848811 hasRelatedWork W2299053288 @default.
- W4210848811 hasRelatedWork W2413223805 @default.
- W4210848811 hasVolume "290" @default.
- W4210848811 isParatext "false" @default.
- W4210848811 isRetracted "false" @default.
- W4210848811 workType "article" @default.