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• W4210850430 endingPage "3089" @default.
• W4210850430 startingPage "3072" @default.
• W4210850430 abstract "Abstract Primitive erythropoiesis is a critical component of the fetal cardiovascular network and is essential for the growth and survival of the mammalian embryo. The need to rapidly establish a functional cardiovascular system is met, in part, by the intravascular circulation of primitive erythroid precursors that mature as a single semisynchronous cohort. To better understand the processes that regulate erythroid precursor maturation, we analyzed the proteome, metabolome, and lipidome of primitive erythroblasts isolated from embryonic day (E) 10.5 and E12.5 of mouse gestation, representing their transition from basophilic erythroblast to orthochromatic erythroblast (OrthoE) stages of maturation. Previous transcriptional and biomechanical characterizations of these precursors have highlighted a transition toward the expression of protein elements characteristic of mature red blood cell structure and function. Our analysis confirmed a loss of organelle-specific protein components involved in messenger RNA processing, proteostasis, and metabolism. In parallel, we observed metabolic rewiring toward the pentose phosphate pathway, glycolysis, and the Rapoport-Luebering shunt. Activation of the pentose phosphate pathway in particular may have stemmed from increased expression of hemoglobin chains and band 3, which together control oxygen-dependent metabolic modulation. Increased expression of several antioxidant enzymes also indicated modification to redox homeostasis. In addition, accumulation of oxylipins and cholesteryl esters in primitive OrthoE cells was paralleled by increased transcript levels of the p53-regulated cholesterol transporter (ABCA1) and decreased transcript levels of cholesterol synthetic enzymes. The present study characterizes the extensive metabolic rewiring that occurs in primary embryonic erythroid precursors as they prepare to enucleate and continue circulating without internal organelles." @default.
• W4210850430 created "2022-02-09" @default.
• W4210850430 creator A5017163801 @default.
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• W4210850430 date "2022-05-18" @default.
• W4210850430 modified "2023-10-12" @default.
• W4210850430 title "Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation" @default.
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• W4210850430 doi "https://doi.org/10.1182/bloodadvances.2021005975" @default.
• W4210850430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35139174" @default.
• W4210850430 hasPublicationYear "2022" @default.
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