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- W4210859652 abstract "<b><i>Background:</i></b> Pancreatic ductal adenocarcinoma (PDAC) is a gland-forming malignancy arising in the pancreas. It is estimated that in developed countries the incidence of PDAC will continue to rise, and PDAC is now the fourth leading cause of cancer-related deaths in the USA. The mortality of PDAC patients closely parallels the incidence rate, as this malignancy generally remains asymptomatic until it reaches an advanced stage. <b><i>Summary:</i></b> The poor prognosis results from the aggressive nature of the tumor, late detection, and resistance to chemotherapy and radiotherapy. Retinoids, vitamin A (retinol) and its metabolites, such as retinoic acid (RA), play critical roles in important biological functions, including cell growth and differentiation, development, metabolism, and immunity. The actions of retinoids in maintaining normal pancreatic functions have generated considerable research interest from investigators interested in understanding and treating PDAC. Altered expression of retinoid receptors and other RA signaling pathway genes in human cancers offers opportunities for target discovery, drug design, and personalized medicine for distinct molecular retinoid subtypes. <b><i>Key Messages:</i></b> The goals of this review are to explore the potential activities of retinoids in the pancreas, to assess the evidence that retinoid functions become dysregulated in PDAC, and to describe the actions of retinoids in new therapies developed to increase patient survival." @default.
- W4210859652 created "2022-02-09" @default.
- W4210859652 creator A5005429262 @default.
- W4210859652 creator A5053798825 @default.
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- W4210859652 date "2022-01-01" @default.
- W4210859652 modified "2023-10-14" @default.
- W4210859652 title "Pancreatic Ductal Adenocarcinoma: New Insights into the Actions of Vitamin A" @default.
- W4210859652 cites W1500816076 @default.
- W4210859652 cites W1503818179 @default.
- W4210859652 cites W1628133229 @default.
- W4210859652 cites W1837432055 @default.
- W4210859652 cites W1878829759 @default.
- W4210859652 cites W1945319061 @default.
- W4210859652 cites W1964048135 @default.
- W4210859652 cites W1964543779 @default.
- W4210859652 cites W1968888940 @default.
- W4210859652 cites W1969831578 @default.
- W4210859652 cites W1970539851 @default.
- W4210859652 cites W1973147485 @default.
- W4210859652 cites W1981599964 @default.
- W4210859652 cites W1983669367 @default.
- W4210859652 cites W1987220381 @default.
- W4210859652 cites W1991313250 @default.
- W4210859652 cites W1993913862 @default.
- W4210859652 cites W1994177577 @default.
- W4210859652 cites W1995496390 @default.
- W4210859652 cites W1996912024 @default.
- W4210859652 cites W1998027923 @default.
- W4210859652 cites W1998544155 @default.
- W4210859652 cites W2009290673 @default.
- W4210859652 cites W2014738732 @default.
- W4210859652 cites W2030901256 @default.
- W4210859652 cites W2031959007 @default.
- W4210859652 cites W2034328471 @default.
- W4210859652 cites W2037970435 @default.
- W4210859652 cites W2040213004 @default.
- W4210859652 cites W2040847490 @default.
- W4210859652 cites W2041381266 @default.
- W4210859652 cites W2042651276 @default.
- W4210859652 cites W2048669411 @default.
- W4210859652 cites W2050601193 @default.
- W4210859652 cites W2050859161 @default.
- W4210859652 cites W2064402415 @default.
- W4210859652 cites W2078165473 @default.
- W4210859652 cites W2079080809 @default.
- W4210859652 cites W2079673038 @default.
- W4210859652 cites W2081923494 @default.
- W4210859652 cites W2083695927 @default.
- W4210859652 cites W2083904574 @default.
- W4210859652 cites W2087404248 @default.
- W4210859652 cites W2089174697 @default.
- W4210859652 cites W2091799578 @default.
- W4210859652 cites W2096343073 @default.
- W4210859652 cites W2102304454 @default.
- W4210859652 cites W2102803053 @default.
- W4210859652 cites W2108254285 @default.
- W4210859652 cites W2108741557 @default.
- W4210859652 cites W2111288662 @default.
- W4210859652 cites W2122808667 @default.
- W4210859652 cites W2123412097 @default.
- W4210859652 cites W2123852594 @default.
- W4210859652 cites W2128746061 @default.
- W4210859652 cites W2133506852 @default.
- W4210859652 cites W2141478391 @default.
- W4210859652 cites W2144869905 @default.
- W4210859652 cites W2145962904 @default.
- W4210859652 cites W2147582263 @default.
- W4210859652 cites W2148078342 @default.
- W4210859652 cites W2151253787 @default.
- W4210859652 cites W2157733612 @default.
- W4210859652 cites W2157739976 @default.
- W4210859652 cites W2159159025 @default.
- W4210859652 cites W2162561885 @default.
- W4210859652 cites W2163112976 @default.
- W4210859652 cites W2165480504 @default.
- W4210859652 cites W2181261671 @default.
- W4210859652 cites W2192855047 @default.
- W4210859652 cites W2285174330 @default.
- W4210859652 cites W2291790203 @default.
- W4210859652 cites W2336612200 @default.
- W4210859652 cites W2337683177 @default.
- W4210859652 cites W2416217723 @default.
- W4210859652 cites W2463926211 @default.
- W4210859652 cites W2510391033 @default.
- W4210859652 cites W2512572928 @default.
- W4210859652 cites W2546965449 @default.
- W4210859652 cites W2560508005 @default.
- W4210859652 cites W2561394427 @default.
- W4210859652 cites W2570618306 @default.
- W4210859652 cites W2588727861 @default.
- W4210859652 cites W2593410994 @default.
- W4210859652 cites W2802707526 @default.
- W4210859652 cites W2894046142 @default.
- W4210859652 cites W2898368508 @default.
- W4210859652 cites W2920686366 @default.
- W4210859652 cites W2921682352 @default.
- W4210859652 cites W2929149171 @default.