FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210868143> ?p ?o ?g. }

• W4210868143 abstract "Cognitive impairment (CI) is among the most common non-motor symptoms of Parkinson's disease (PD), with a substantially negative impact on patient management and outcome. The development and progression of CI exhibits high interindividual variability, which requires better diagnostic and monitoring strategies. PD patients often display sweating disorders resulting from autonomic dysfunction, which has been associated with CI. Because the axillary microbiota is known to change with humidity level and sweat composition, we hypothesized that the axillary microbiota of PD patients shifts in association with CI progression, and thus can be used as a proxy for classification of CI stages in PD. We compared the axillary microbiota compositions of 103 PD patients (55 PD patients with dementia [PDD] and 48 PD patients with mild cognitive impairment [PD-MCI]) and 26 cognitively normal healthy controls (HC). We found that axillary microbiota profiles differentiate HC, PD-MCI, and PDD groups based on differential ranking analysis, and detected an increasing trend in the log ratio of Corynebacterium to Anaerococcus in progression from HC to PDD. In addition, phylogenetic factorization revealed that the depletion of the Anaerococcus, Peptoniphilus, and W5053 genera is associated with PD-MCI and PDD. Moreover, functional predictions suggested significant increases in myo-inositol degradation, ergothioneine biosynthesis, propionate biosynthesis, menaquinone biosynthesis, and the proportion of aerobic bacteria and biofilm formation capacity, in parallel to increasing CI. Our results suggest that alterations in axillary microbiota are associated with CI in PD. Thus, axillary microbiota has the potential to be exploited as a noninvasive tool in the development of novel strategies. IMPORTANCE Parkinson's disease (PD) is the second most common neurodegenerative disease. Cognitive impairment (CI) in PD has significant negative impacts on life quality of patients. The emergence and progression of cognitive impairment shows high variability among PD patients, and thus requires better diagnostic and monitoring strategies. Recent findings indicate a close link between autonomic dysfunction and cognitive impairment. Since thermoregulatory dysfunction and skin changes are among the main manifestations of autonomic dysfunction in PD, we hypothesized that alterations in the axillary microbiota may be useful for tracking cognitive impairment stages in PD. To our knowledge, this the first study characterizing the axillary microbiota of PD patients and exploring its association with cognitive impairment stages in PD. Future studies should include larger cohorts and multicenter studies to validate our results and investigate potential biological mechanisms." @default.
• W4210868143 created "2022-02-09" @default.
• W4210868143 creator A5026473473 @default.
• W4210868143 creator A5031840327 @default.
• W4210868143 creator A5037614127 @default.
• W4210868143 creator A5051418409 @default.
• W4210868143 creator A5051772474 @default.
• W4210868143 creator A5052818360 @default.
• W4210868143 creator A5066011256 @default.
• W4210868143 date "2022-02-23" @default.
• W4210868143 modified "2023-10-17" @default.
• W4210868143 title "Axillary Microbiota Is Associated with Cognitive Impairment in Parkinson’s Disease Patients" @default.
• W4210868143 cites W1963528082 @default.
• W4210868143 cites W1985062780 @default.
• W4210868143 cites W1987197936 @default.
• W4210868143 cites W2034285706 @default.
• W4210868143 cites W2056279562 @default.
• W4210868143 cites W2115701239 @default.
• W4210868143 cites W2156013560 @default.
• W4210868143 cites W2166171121 @default.
• W4210868143 cites W2293713895 @default.
• W4210868143 cites W2508023300 @default.
• W4210868143 cites W2555202449 @default.
• W4210868143 cites W2555932918 @default.
• W4210868143 cites W2556385052 @default.
• W4210868143 cites W2578475518 @default.
• W4210868143 cites W2611146598 @default.
• W4210868143 cites W2756438808 @default.
• W4210868143 cites W2760290205 @default.
• W4210868143 cites W2771043801 @default.
• W4210868143 cites W2784164089 @default.
• W4210868143 cites W2802324252 @default.
• W4210868143 cites W2900983333 @default.
• W4210868143 cites W2911520506 @default.
• W4210868143 cites W2915888768 @default.
• W4210868143 cites W2950067305 @default.
• W4210868143 cites W2951061751 @default.
• W4210868143 cites W2952463830 @default.
• W4210868143 cites W2963276645 @default.
• W4210868143 cites W2967674535 @default.
• W4210868143 cites W3022006686 @default.
• W4210868143 cites W3030441098 @default.
• W4210868143 cites W3087945872 @default.
• W4210868143 cites W3093994795 @default.
• W4210868143 cites W3109539788 @default.
• W4210868143 cites W3118629821 @default.
• W4210868143 cites W3127379712 @default.
• W4210868143 cites W3137147084 @default.
• W4210868143 cites W3192544272 @default.
• W4210868143 cites W3211779138 @default.
• W4210868143 cites W4230096730 @default.
• W4210868143 cites W98651834 @default.
• W4210868143 doi "https://doi.org/10.1128/spectrum.02358-21" @default.
• W4210868143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35138147" @default.
• W4210868143 hasPublicationYear "2022" @default.
• W4210868143 type Work @default.
• W4210868143 citedByCount "1" @default.
• W4210868143 countsByYear W42108681432022 @default.
• W4210868143 crossrefType "journal-article" @default.
• W4210868143 hasAuthorship W4210868143A5026473473 @default.
• W4210868143 hasAuthorship W4210868143A5031840327 @default.
• W4210868143 hasAuthorship W4210868143A5037614127 @default.
• W4210868143 hasAuthorship W4210868143A5051418409 @default.
• W4210868143 hasAuthorship W4210868143A5051772474 @default.
• W4210868143 hasAuthorship W4210868143A5052818360 @default.
• W4210868143 hasAuthorship W4210868143A5066011256 @default.
• W4210868143 hasBestOaLocation W42108681431 @default.
• W4210868143 hasConcept C126322002 @default.
• W4210868143 hasConcept C203014093 @default.
• W4210868143 hasConcept C2777165150 @default.
• W4210868143 hasConcept C2779134260 @default.
• W4210868143 hasConcept C2779483572 @default.
• W4210868143 hasConcept C2779734285 @default.
• W4210868143 hasConcept C42407357 @default.
• W4210868143 hasConcept C539455810 @default.
• W4210868143 hasConcept C71924100 @default.
• W4210868143 hasConcept C86803240 @default.
• W4210868143 hasConceptScore W4210868143C126322002 @default.
• W4210868143 hasConceptScore W4210868143C203014093 @default.
• W4210868143 hasConceptScore W4210868143C2777165150 @default.
• W4210868143 hasConceptScore W4210868143C2779134260 @default.
• W4210868143 hasConceptScore W4210868143C2779483572 @default.
• W4210868143 hasConceptScore W4210868143C2779734285 @default.
• W4210868143 hasConceptScore W4210868143C42407357 @default.
• W4210868143 hasConceptScore W4210868143C539455810 @default.
• W4210868143 hasConceptScore W4210868143C71924100 @default.
• W4210868143 hasConceptScore W4210868143C86803240 @default.
• W4210868143 hasFunder F4320322626 @default.
• W4210868143 hasIssue "1" @default.
• W4210868143 hasLocation W42108681431 @default.
• W4210868143 hasLocation W42108681432 @default.
• W4210868143 hasLocation W42108681433 @default.
• W4210868143 hasLocation W42108681434 @default.
• W4210868143 hasLocation W42108681435 @default.
• W4210868143 hasOpenAccess W4210868143 @default.
• W4210868143 hasPrimaryLocation W42108681431 @default.
• W4210868143 hasRelatedWork W2904360832 @default.
• W4210868143 hasRelatedWork W3153668192 @default.
• W4210868143 hasRelatedWork W3155677729 @default.
• W4210868143 hasRelatedWork W3173560251 @default.

• next