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- W4210886182 abstract "This work demonstrates the optimization of an efficient, mild, and environmentally friendly synthetic approach to access a diverse library of N-naphthoyl thioureas. These derivatives could be exploited as precursor scaffolds for designing valuable heterocycles with anticipated biological activities. Additionally, the utilization of a copper complex derived from the newly synthesized N-naphthoyl thiourea ligand in the photodegradation of methyl orange (MO) dye was explored. The antiproliferative effect of the synthesized derivatives was examined against MCF-7, HCT116, and A549 cancer cell lines. Most of the assembled derivatives revealed a significant cytotoxic effect, in some cases, greater than doxorubicin. Of these, the copper complex demonstrated significant antitumor activities (IC50 < 1.3 μM) and lesser cytotoxic impact (IC50 > 76 μM), indicating its possibility as a pioneering candidate for future carcinogenic pharmaceutics. Relations between the structure and activity also have been addressed." @default.
- W4210886182 created "2022-02-09" @default.
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- W4210886182 date "2022-02-09" @default.
- W4210886182 modified "2023-10-18" @default.
- W4210886182 title "<i>N</i>-Naphthoyl Thiourea Derivatives: An Efficient Ultrasonic-Assisted Synthesis, Reaction, and <i>In Vitro</i> Anticancer Evaluations" @default.
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- W4210886182 doi "https://doi.org/10.1021/acsomega.1c06718" @default.
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