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• W4210909788 endingPage "156" @default.
• W4210909788 startingPage "146" @default.
• W4210909788 abstract "Endometriosis is a chronic inflammatory gynecologic disorder characterized by the presence of endometrial glands and stroma throughout the abdominopelvic cavity, including the surfaces of the ovaries, uterus, fallopian tubes, small and large bowel, and anterior/posterior cul-de-sacs. Research on the pathophysiology of endometriosis has revealed several biologically active proinflammatory mediators, such as myeloperoxidase (MPO), reactive oxygen species, and free iron. The generation of free iron is believed to be driven by high activity of inducible heme oxygenase; however, this does not fully explain the clinical features of endometriosis, such as implantation, hypoxic stress, appearance of lesions, or marked elevations of free iron. Therefore, this review proposes a new theory highlighting that MPO, and subsequently generated hypochlorous acid, may direct the ectopic implantation of endometrial tissue and progression of endometriosis via tissue hypoxia and angiogenesis and modulation of inducible heme oxygenase activity, free iron generation, and increased reactive oxygen species activity. Furthermore, we discuss the pathway in which MPO-hypochlorous acid directly and indirectly impacts the follicular microenvironment and oocyte, contributing to endometriosis-associated infertility. We conclude with the hypothesis that these adverse effects may be attenuated through antioxidant supplementation, such as lycopene or melatonin. Endometriosis is a chronic inflammatory gynecologic disorder characterized by the presence of endometrial glands and stroma throughout the abdominopelvic cavity, including the surfaces of the ovaries, uterus, fallopian tubes, small and large bowel, and anterior/posterior cul-de-sacs. Research on the pathophysiology of endometriosis has revealed several biologically active proinflammatory mediators, such as myeloperoxidase (MPO), reactive oxygen species, and free iron. The generation of free iron is believed to be driven by high activity of inducible heme oxygenase; however, this does not fully explain the clinical features of endometriosis, such as implantation, hypoxic stress, appearance of lesions, or marked elevations of free iron. Therefore, this review proposes a new theory highlighting that MPO, and subsequently generated hypochlorous acid, may direct the ectopic implantation of endometrial tissue and progression of endometriosis via tissue hypoxia and angiogenesis and modulation of inducible heme oxygenase activity, free iron generation, and increased reactive oxygen species activity. Furthermore, we discuss the pathway in which MPO-hypochlorous acid directly and indirectly impacts the follicular microenvironment and oocyte, contributing to endometriosis-associated infertility. We conclude with the hypothesis that these adverse effects may be attenuated through antioxidant supplementation, such as lycopene or melatonin." @default.
• W4210909788 created "2022-02-09" @default.
• W4210909788 creator A5005306051 @default.
• W4210909788 creator A5013450877 @default.
• W4210909788 creator A5054869923 @default.
• W4210909788 creator A5077074927 @default.
• W4210909788 creator A5086986142 @default.
• W4210909788 date "2022-05-01" @default.
• W4210909788 modified "2023-09-27" @default.
• W4210909788 title "A novel theory implicating hypochlorous acid as the primary generator of angiogenesis, infertility, and free iron in endometriosis" @default.
• W4210909788 cites W1519147845 @default.
• W4210909788 cites W1546742128 @default.
• W4210909788 cites W1579357450 @default.
• W4210909788 cites W1824521117 @default.
• W4210909788 cites W1940436875 @default.
• W4210909788 cites W1964093919 @default.
• W4210909788 cites W1965081805 @default.
• W4210909788 cites W1965459361 @default.
• W4210909788 cites W1967948940 @default.
• W4210909788 cites W1969263330 @default.
• W4210909788 cites W1969421128 @default.
• W4210909788 cites W1975381191 @default.
• W4210909788 cites W1976299761 @default.
• W4210909788 cites W1976593248 @default.
• W4210909788 cites W1986952926 @default.
• W4210909788 cites W1998412842 @default.
• W4210909788 cites W2003749942 @default.
• W4210909788 cites W2004241496 @default.
• W4210909788 cites W2004283265 @default.
• W4210909788 cites W2006754144 @default.
• W4210909788 cites W2007654790 @default.
• W4210909788 cites W2009760139 @default.
• W4210909788 cites W2011372300 @default.
• W4210909788 cites W2014321361 @default.
• W4210909788 cites W2018992923 @default.
• W4210909788 cites W2019627521 @default.
• W4210909788 cites W2019843041 @default.
• W4210909788 cites W2023020387 @default.
• W4210909788 cites W2031361052 @default.
• W4210909788 cites W2035568334 @default.
• W4210909788 cites W2036459481 @default.
• W4210909788 cites W2038134765 @default.
• W4210909788 cites W2039152389 @default.
• W4210909788 cites W2040726024 @default.
• W4210909788 cites W2041394922 @default.
• W4210909788 cites W2044474988 @default.
• W4210909788 cites W2046381495 @default.
• W4210909788 cites W2046690044 @default.
• W4210909788 cites W2048198010 @default.
• W4210909788 cites W2048554453 @default.
• W4210909788 cites W2061427976 @default.
• W4210909788 cites W2062398216 @default.
• W4210909788 cites W2062806267 @default.
• W4210909788 cites W2063850046 @default.
• W4210909788 cites W2066949075 @default.
• W4210909788 cites W2067152905 @default.
• W4210909788 cites W2068010495 @default.
• W4210909788 cites W2070522963 @default.
• W4210909788 cites W2070805231 @default.
• W4210909788 cites W2072651499 @default.
• W4210909788 cites W2075495986 @default.
• W4210909788 cites W2076458139 @default.
• W4210909788 cites W2077587761 @default.
• W4210909788 cites W2078456182 @default.
• W4210909788 cites W2080983244 @default.
• W4210909788 cites W2083558299 @default.
• W4210909788 cites W2083712604 @default.
• W4210909788 cites W2084838353 @default.
• W4210909788 cites W2085933450 @default.
• W4210909788 cites W2085977860 @default.
• W4210909788 cites W2086090458 @default.
• W4210909788 cites W2089219113 @default.
• W4210909788 cites W2091924757 @default.
• W4210909788 cites W2092865574 @default.
• W4210909788 cites W2095796001 @default.
• W4210909788 cites W2106029185 @default.
• W4210909788 cites W2117374842 @default.
• W4210909788 cites W2119501943 @default.
• W4210909788 cites W2119781626 @default.
• W4210909788 cites W2126253259 @default.
• W4210909788 cites W2130774259 @default.
• W4210909788 cites W2131489846 @default.
• W4210909788 cites W2132826785 @default.
• W4210909788 cites W2134343103 @default.
• W4210909788 cites W2135489538 @default.
• W4210909788 cites W2145550766 @default.
• W4210909788 cites W2146656685 @default.
• W4210909788 cites W2151417342 @default.
• W4210909788 cites W2151618269 @default.
• W4210909788 cites W2155690375 @default.
• W4210909788 cites W2156032042 @default.
• W4210909788 cites W2162415072 @default.
• W4210909788 cites W2165796896 @default.
• W4210909788 cites W2168439614 @default.
• W4210909788 cites W2208430455 @default.
• W4210909788 cites W2304103551 @default.
• W4210909788 cites W2313678972 @default.
• W4210909788 cites W2319582451 @default.

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