FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210913887> ?p ?o ?g. }

• W4210913887 endingPage "669" @default.
• W4210913887 startingPage "658" @default.
• W4210913887 abstract "Recruitment rates for Crohn's disease and ulcerative colitis clinical trials continue to decrease annually. The inability to reach recruitment targets and complete trials has serious implications for stakeholders in the inflammatory bowel disease (IBD) community. Action is required to ensure patients with an unmet medical need have access to new therapies to improve the management of their IBD.Identify challenges contributing to recruitment decline in IBD clinical trials and propose potential solutions.PubMed and Google were used to identify literature, regulatory guidelines and conference proceedings related to IBD clinical trials and related concepts. Data on IBD clinical trials conducted between 1989 and 2020 were extracted from the Trialtrove database.Key aspects that may improve recruitment rates were identified. An increasingly patient-centric approach should be taken to study design including improvements to the readability of key trial documentation and inclusion of patient representatives in trial planning. Placebo is unappealing to patients; approaches including platform trials should be explored to minimise placebo exposure. Non-invasive imaging, biomarkers and novel digital endpoints should continue to be examined to reduce the burden on patients. Reducing the administrative burden associated with trials via the use of electronic signatures, for example, may benefit study sites and investigators. Changes implemented to IBD trials during the COVID-19 pandemic provided examples of how trial conduct can be rapidly and constructively adapted.To improve recruitment in Crohn's disease and ulcerative colitis trials, the IBD community should address a broad range of issues related to clinical trial conduct." @default.
• W4210913887 created "2022-02-09" @default.
• W4210913887 creator A5015953257 @default.
• W4210913887 creator A5021116736 @default.
• W4210913887 creator A5022022076 @default.
• W4210913887 creator A5031136418 @default.
• W4210913887 creator A5043230834 @default.
• W4210913887 creator A5045626036 @default.
• W4210913887 creator A5045650183 @default.
• W4210913887 creator A5047563454 @default.
• W4210913887 creator A5059435501 @default.
• W4210913887 creator A5064276019 @default.
• W4210913887 date "2022-02-07" @default.
• W4210913887 modified "2023-10-09" @default.
• W4210913887 title "Review article: randomised controlled trials in inflammatory bowel disease—common challenges and potential solutions" @default.
• W4210913887 cites W1547943993 @default.
• W4210913887 cites W1834872163 @default.
• W4210913887 cites W1965952543 @default.
• W4210913887 cites W1967833059 @default.
• W4210913887 cites W2012110426 @default.
• W4210913887 cites W2020640954 @default.
• W4210913887 cites W2039234374 @default.
• W4210913887 cites W2092863985 @default.
• W4210913887 cites W2138201492 @default.
• W4210913887 cites W2162805528 @default.
• W4210913887 cites W2171297959 @default.
• W4210913887 cites W2209274739 @default.
• W4210913887 cites W2229293842 @default.
• W4210913887 cites W2230795721 @default.
• W4210913887 cites W2314735134 @default.
• W4210913887 cites W2328481225 @default.
• W4210913887 cites W2463718837 @default.
• W4210913887 cites W2512083002 @default.
• W4210913887 cites W2518767134 @default.
• W4210913887 cites W2530226391 @default.
• W4210913887 cites W2580410027 @default.
• W4210913887 cites W2584203780 @default.
• W4210913887 cites W2591573858 @default.
• W4210913887 cites W2611548364 @default.
• W4210913887 cites W2623019834 @default.
• W4210913887 cites W2753535533 @default.
• W4210913887 cites W2778088240 @default.
• W4210913887 cites W2779922261 @default.
• W4210913887 cites W2783103617 @default.
• W4210913887 cites W2785800471 @default.
• W4210913887 cites W2789874222 @default.
• W4210913887 cites W2790434969 @default.
• W4210913887 cites W2800544499 @default.
• W4210913887 cites W2806361671 @default.
• W4210913887 cites W2809712191 @default.
• W4210913887 cites W2888061430 @default.
• W4210913887 cites W2910890040 @default.
• W4210913887 cites W2921733977 @default.
• W4210913887 cites W2945330085 @default.
• W4210913887 cites W2947189704 @default.
• W4210913887 cites W2949654782 @default.
• W4210913887 cites W2964277243 @default.
• W4210913887 cites W2969096507 @default.
• W4210913887 cites W2969285468 @default.
• W4210913887 cites W2973439892 @default.
• W4210913887 cites W2974694595 @default.
• W4210913887 cites W2980144960 @default.
• W4210913887 cites W2982224439 @default.
• W4210913887 cites W2984675782 @default.
• W4210913887 cites W2991064810 @default.
• W4210913887 cites W2995711171 @default.
• W4210913887 cites W3001057465 @default.
• W4210913887 cites W3006764495 @default.
• W4210913887 cites W3007153876 @default.
• W4210913887 cites W3010700640 @default.
• W4210913887 cites W3011041837 @default.
• W4210913887 cites W3012151322 @default.
• W4210913887 cites W3012877162 @default.
• W4210913887 cites W3014470228 @default.
• W4210913887 cites W3016669010 @default.
• W4210913887 cites W3040508995 @default.
• W4210913887 cites W3040947514 @default.
• W4210913887 cites W3043034473 @default.
• W4210913887 cites W3083313255 @default.
• W4210913887 cites W3083733784 @default.
• W4210913887 cites W3091069714 @default.
• W4210913887 cites W3100152466 @default.
• W4210913887 cites W3106951843 @default.
• W4210913887 cites W3112415181 @default.
• W4210913887 cites W3115410759 @default.
• W4210913887 cites W3122201315 @default.
• W4210913887 cites W4205253993 @default.
• W4210913887 cites W4211138554 @default.
• W4210913887 cites W437024349 @default.
• W4210913887 cites W4378072791 @default.
• W4210913887 doi "https://doi.org/10.1111/apt.16781" @default.
• W4210913887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35132657" @default.
• W4210913887 hasPublicationYear "2022" @default.
• W4210913887 type Work @default.
• W4210913887 citedByCount "7" @default.
• W4210913887 countsByYear W42109138872022 @default.
• W4210913887 countsByYear W42109138872023 @default.
• W4210913887 crossrefType "journal-article" @default.

• next