Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210917656> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W4210917656 abstract "There is presently great interest in mechanisms of acquired resistance to epidermal growth factor receptor (EGFR) inhibitors that are now being used widely in the treatment of a variety of common human cancers. To investigate these mechanisms, we established EGFR inhibitor-resistant clones from non-small cell lung cancer cells. A comparative analysis revealed that acquired resistance to EGFR inhibitors was associated consistently with the loss of p53 and cross-resistance to radiation. To examine the role of p53, we first knocked down p53 in sensitive parental cells and found a reduction in sensitivity to both EGFR inhibitors and radiation. Conversely, restoration of functional p53 in EGFR inhibitor-resistant cells was sufficient to resensitize them to EGFR inhibitors or radiation in vitro and in vivo. Further studies indicate that p53 may enhance sensitivity to EGFR inhibitors and radiation via induction of cell-cycle arrest, apoptosis, and DNA damage repair. Taken together, these findings suggest a central role of p53 in the development of acquired resistance to EGFR inhibitors and prompt consideration to apply p53 restoration strategies in future clinical trials that combine EGFR inhibitors and radiation.©2011 AACR PMID: 22068033 Funding information This work was supported by: NCRR NIH HHS, United States Grant ID: UL1 RR025011-05 NCI NIH HHS, United States Grant ID: R01 CA 113448-01 NCI NIH HHS, United States Grant ID: R01 CA113448-03 NCRR NIH HHS, United States Grant ID: UL1 RR025011 NCI NIH HHS, United States Grant ID: R01 CA113448" @default.
- W4210917656 created "2022-02-09" @default.
- W4210917656 creator A5008093569 @default.
- W4210917656 creator A5075201353 @default.
- W4210917656 date "2011-11-28" @default.
- W4210917656 modified "2023-10-05" @default.
- W4210917656 title "Faculty Opinions recommendation of p53 modulates acquired resistance to EGFR inhibitors and radiation." @default.
- W4210917656 doi "https://doi.org/10.3410/f.13380981.14750092" @default.
- W4210917656 hasPublicationYear "2011" @default.
- W4210917656 type Work @default.
- W4210917656 citedByCount "0" @default.
- W4210917656 crossrefType "dataset" @default.
- W4210917656 hasAuthorship W4210917656A5008093569 @default.
- W4210917656 hasAuthorship W4210917656A5075201353 @default.
- W4210917656 hasBestOaLocation W42109176561 @default.
- W4210917656 hasConcept C121608353 @default.
- W4210917656 hasConcept C126322002 @default.
- W4210917656 hasConcept C143998085 @default.
- W4210917656 hasConcept C190283241 @default.
- W4210917656 hasConcept C2776256026 @default.
- W4210917656 hasConcept C2777506169 @default.
- W4210917656 hasConcept C2779438470 @default.
- W4210917656 hasConcept C502942594 @default.
- W4210917656 hasConcept C509974204 @default.
- W4210917656 hasConcept C54355233 @default.
- W4210917656 hasConcept C71924100 @default.
- W4210917656 hasConcept C86803240 @default.
- W4210917656 hasConceptScore W4210917656C121608353 @default.
- W4210917656 hasConceptScore W4210917656C126322002 @default.
- W4210917656 hasConceptScore W4210917656C143998085 @default.
- W4210917656 hasConceptScore W4210917656C190283241 @default.
- W4210917656 hasConceptScore W4210917656C2776256026 @default.
- W4210917656 hasConceptScore W4210917656C2777506169 @default.
- W4210917656 hasConceptScore W4210917656C2779438470 @default.
- W4210917656 hasConceptScore W4210917656C502942594 @default.
- W4210917656 hasConceptScore W4210917656C509974204 @default.
- W4210917656 hasConceptScore W4210917656C54355233 @default.
- W4210917656 hasConceptScore W4210917656C71924100 @default.
- W4210917656 hasConceptScore W4210917656C86803240 @default.
- W4210917656 hasLocation W42109176561 @default.
- W4210917656 hasOpenAccess W4210917656 @default.
- W4210917656 hasPrimaryLocation W42109176561 @default.
- W4210917656 hasRelatedWork W2007766970 @default.
- W4210917656 hasRelatedWork W2054822224 @default.
- W4210917656 hasRelatedWork W2092134708 @default.
- W4210917656 hasRelatedWork W2107312379 @default.
- W4210917656 hasRelatedWork W2186047679 @default.
- W4210917656 hasRelatedWork W2407189953 @default.
- W4210917656 hasRelatedWork W2542192317 @default.
- W4210917656 hasRelatedWork W3042289395 @default.
- W4210917656 hasRelatedWork W3044237032 @default.
- W4210917656 hasRelatedWork W2597201175 @default.
- W4210917656 isParatext "false" @default.
- W4210917656 isRetracted "false" @default.
- W4210917656 workType "dataset" @default.