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- W4210921729 abstract "Abstract The aim of the study was to evaluate the role of pseudocontinuous arterial spin labeling perfusion (pCASL-perfusion) in preoperative assessment of cerebral glioma grades. The study group consisted of 253 patients, aged 7–78 years with supratentorial gliomas (65 low-grade gliomas (LGG), 188 high-grade gliomas (HGG)). We used 3D pCASL-perfusion for each patient in order to calculate the tumor blood flow (TBF). We obtained maximal tumor blood flow (maxTBF) in small regions of interest (30 ± 10 mm 2 ) and then normalized absolute maximum tumor blood flow (nTBF) to that of the contralateral normal-appearing white matter of the centrum semiovale. MaxTBF and nTBF values significantly differed between HGG and LGG groups ( p < 0.001), as well as between patient groups separated by the grades (grade II vs. grade III) ( p < 0.001). Moreover, we performed ROC-analysis which demonstrated high sensitivity and specificity in differentiating between HGG and LGG. We found significant differences for maxTBF and nTBF between grade III and IV gliomas, however, ROC-analysis showed low sensitivity and specificity. We did not observe a significant difference in TBF for astrocytomas and oligodendrogliomas. Our study demonstrates that 3D pCASL-perfusion as an effective diagnostic tool for preoperative differentiation of glioma grades." @default.
- W4210921729 created "2022-02-09" @default.
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- W4210921729 date "2022-02-08" @default.
- W4210921729 modified "2023-10-01" @default.
- W4210921729 title "3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients" @default.
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- W4210921729 doi "https://doi.org/10.1038/s41598-022-05992-4" @default.
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