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- W4210921884 abstract "Toll-like receptors (TLRs) detect microbial infection and play an essential role in the induction of innate and adaptive immune responses. The mechanisms of TLR-mediated control of adaptive immunity are not yet fully understood. Induction of dendritic cell (DC) maturation is essential for activation of naive T cells. Here, we demonstrate that TLR-induced DC maturation and migration to the lymph nodes, in the absence of TLR-induced inflammatory cytokines, are not sufficient for T cell activation in vivo. We show that transient depletion of regulatory T (Tr) cells recovers the primary CD4 T cells response in MyD88-deficient mice, demonstrating that a major mechanism of TLR-mediated activation of T cell responses is the blocking of suppression by regulatory T cells. In addition we show that a TLR-induced signal(s) is required for memory CD4 T cell differentiation, but not for activation of memory T cells. PMID: 15539158 Funding information This work was supported by: NIAID NIH HHS, United States Grant ID: AI 05502" @default.
- W4210921884 created "2022-02-09" @default.
- W4210921884 creator A5059761327 @default.
- W4210921884 date "2004-11-23" @default.
- W4210921884 modified "2023-09-28" @default.
- W4210921884 title "Faculty Opinions recommendation of Toll-dependent control mechanisms of CD4 T cell activation." @default.
- W4210921884 doi "https://doi.org/10.3410/f.1012546.255636" @default.
- W4210921884 hasPublicationYear "2004" @default.
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