Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210926054> ?p ?o ?g. }
- W4210926054 abstract "Many neurodegenerative diseases are neuropathologically characterized by neuronal loss, gliosis, and the deposition of misfolded proteins such as β-amyloid (Aβ) plaques and tau tangles in Alzheimer's disease (AD). In postmortem AD brains, reactive astrocytes and activated microglia are observed surrounding Aβ plaques and tau tangles. These activated glial cells secrete pro-inflammatory cytokines and reactive oxygen species, which may contribute to neurodegeneration. Therefore, in vivo imaging of glial response by positron emission tomography (PET) combined with Aβ and tau PET would provide new insights to better understand the disease process, as well as aid in the differential diagnosis, and monitoring glial response disease-specific therapeutics. There are two promising targets proposed for imaging reactive astrogliosis: monoamine oxidase-B (MAO-B) and imidazoline2 binding site (I2BS), which are predominantly expressed in the mitochondrial membranes of astrocytes and are upregulated in various neurodegenerative conditions. PET tracers targeting these two MAO-B and I2BS have been evaluated in humans. [18F]THK-5351, which was originally designed to target tau aggregates in AD, showed high affinity for MAO-B and clearly visualized reactive astrocytes in progressive supranuclear palsy (PSP). However, the lack of selectivity of [18F]THK-5351 binding to both MAO-B and tau, severely limits its clinical utility as a biomarker. Recently, [18F]SMBT-1 was developed as a selective and reversible MAO-B PET tracer via compound optimization of [18F]THK-5351. In this review, we summarize the strategy underlying molecular imaging of reactive astrogliosis and clinical studies using MAO-B and I2BS PET tracers." @default.
- W4210926054 created "2022-02-09" @default.
- W4210926054 creator A5017027985 @default.
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- W4210926054 creator A5058052951 @default.
- W4210926054 creator A5063415107 @default.
- W4210926054 creator A5065225018 @default.
- W4210926054 date "2022-02-08" @default.
- W4210926054 modified "2023-10-18" @default.
- W4210926054 title "Imaging of Reactive Astrogliosis by Positron Emission Tomography" @default.
- W4210926054 cites W1503335808 @default.
- W4210926054 cites W1525558041 @default.
- W4210926054 cites W1547548853 @default.
- W4210926054 cites W168886292 @default.
- W4210926054 cites W1865287979 @default.
- W4210926054 cites W1934549153 @default.
- W4210926054 cites W1963860273 @default.
- W4210926054 cites W1964079539 @default.
- W4210926054 cites W1964590338 @default.
- W4210926054 cites W1972899609 @default.
- W4210926054 cites W1974663369 @default.
- W4210926054 cites W1975978765 @default.
- W4210926054 cites W1980610999 @default.
- W4210926054 cites W1984009511 @default.
- W4210926054 cites W1984689203 @default.
- W4210926054 cites W1989201276 @default.
- W4210926054 cites W1991128766 @default.
- W4210926054 cites W1995528771 @default.
- W4210926054 cites W2000225222 @default.
- W4210926054 cites W2009077522 @default.
- W4210926054 cites W2010663073 @default.
- W4210926054 cites W2011314392 @default.
- W4210926054 cites W2012516949 @default.
- W4210926054 cites W2013489516 @default.
- W4210926054 cites W2014028464 @default.
- W4210926054 cites W2014895137 @default.
- W4210926054 cites W2020574854 @default.
- W4210926054 cites W2022043510 @default.
- W4210926054 cites W2024770800 @default.
- W4210926054 cites W2032352955 @default.
- W4210926054 cites W2032643752 @default.
- W4210926054 cites W2033759470 @default.
- W4210926054 cites W2034852720 @default.
- W4210926054 cites W2037818212 @default.
- W4210926054 cites W2038337878 @default.
- W4210926054 cites W2038419555 @default.
- W4210926054 cites W2041636112 @default.
- W4210926054 cites W2042386533 @default.
- W4210926054 cites W2042695207 @default.
- W4210926054 cites W2048128191 @default.
- W4210926054 cites W2069885465 @default.
- W4210926054 cites W2070458400 @default.
- W4210926054 cites W2073673434 @default.
- W4210926054 cites W2075755119 @default.
- W4210926054 cites W2079313884 @default.
- W4210926054 cites W2082429191 @default.
- W4210926054 cites W2089875406 @default.
- W4210926054 cites W2090620788 @default.
- W4210926054 cites W2091101912 @default.
- W4210926054 cites W2091243484 @default.
- W4210926054 cites W2093781635 @default.
- W4210926054 cites W2103598429 @default.
- W4210926054 cites W2107804537 @default.
- W4210926054 cites W2108364115 @default.
- W4210926054 cites W2108901526 @default.
- W4210926054 cites W2111595594 @default.
- W4210926054 cites W2111904695 @default.
- W4210926054 cites W2116448213 @default.
- W4210926054 cites W2116591217 @default.
- W4210926054 cites W2137864613 @default.
- W4210926054 cites W2141706699 @default.
- W4210926054 cites W2142456895 @default.
- W4210926054 cites W2154353967 @default.
- W4210926054 cites W2154780300 @default.
- W4210926054 cites W2157816812 @default.
- W4210926054 cites W2196268942 @default.
- W4210926054 cites W2208088507 @default.
- W4210926054 cites W2219920450 @default.
- W4210926054 cites W2257502804 @default.
- W4210926054 cites W2276853091 @default.
- W4210926054 cites W2321391711 @default.
- W4210926054 cites W2330791837 @default.
- W4210926054 cites W2462362682 @default.
- W4210926054 cites W2545175005 @default.
- W4210926054 cites W2546313121 @default.
- W4210926054 cites W2549184735 @default.
- W4210926054 cites W2560534594 @default.
- W4210926054 cites W2572710398 @default.
- W4210926054 cites W2602659814 @default.
- W4210926054 cites W2602908130 @default.
- W4210926054 cites W2738881219 @default.
- W4210926054 cites W2747632345 @default.
- W4210926054 cites W2750990748 @default.
- W4210926054 cites W2761121091 @default.
- W4210926054 cites W2767131549 @default.
- W4210926054 cites W2768094121 @default.
- W4210926054 cites W2779391140 @default.
- W4210926054 cites W2782185896 @default.
- W4210926054 cites W2792164441 @default.