Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210927976> ?p ?o ?g. }
- W4210927976 endingPage "2941" @default.
- W4210927976 startingPage "2928" @default.
- W4210927976 abstract "Self-assembly of metallointercalators into DNA nanocages is a rapid and facile approach to synthesize discrete bioinorganic host/guest structures with a high load of metal complexes. Turberfield's DNA tetrahedron can accommodate one intercalator for every two base pairs, which corresponds to 48 metallointercalators per DNA tetrahedron. The affinity of the metallointercalator for the DNA tetrahedron is a function of both the structure of the intercalating ligand and the overall charge of the complex, with a trend in affinity [Ru(bpy)2(dppz)]2+ > [Tb-DOTAm-Phen]3+ ≫ Tb-DOTA-Phen. Intercalation of the metal complex stabilizes the DNA tetrahedron, resulting in an increase of its melting temperature and, importantly, a significant increase in its stability in the presence of serum. [Ru(bpy)2(dppz)]2+, which has a greater affinity for DNA than [Tb-DOTAm-Phen]3+, increases the melting point and decreases degradation in serum to a greater extent than the TbIII complex. In the presence of Lipofectamine, the metallointercalator@DNA nanocage assemblies substantially increase the cell uptake of their respective metal complex. Altogether, the facile incorporation of a large number of metal complexes per assembly, the higher stability in serum, and the increased cell penetration of metallointercalator@DNA make these self-assemblies well-suited as metallodrugs." @default.
- W4210927976 created "2022-02-09" @default.
- W4210927976 creator A5002818722 @default.
- W4210927976 creator A5004893465 @default.
- W4210927976 creator A5006176629 @default.
- W4210927976 creator A5013842465 @default.
- W4210927976 creator A5013993451 @default.
- W4210927976 creator A5026233354 @default.
- W4210927976 creator A5044624471 @default.
- W4210927976 creator A5067510984 @default.
- W4210927976 date "2022-02-08" @default.
- W4210927976 modified "2023-10-17" @default.
- W4210927976 title "Metallointercalators-DNA Tetrahedron Supramolecular Self-Assemblies with Increased Serum Stability" @default.
- W4210927976 cites W1481702065 @default.
- W4210927976 cites W153075741 @default.
- W4210927976 cites W1922563352 @default.
- W4210927976 cites W1969436685 @default.
- W4210927976 cites W1972032435 @default.
- W4210927976 cites W1973489898 @default.
- W4210927976 cites W1975198718 @default.
- W4210927976 cites W1981824156 @default.
- W4210927976 cites W1983382833 @default.
- W4210927976 cites W1987354680 @default.
- W4210927976 cites W2004899704 @default.
- W4210927976 cites W2005240531 @default.
- W4210927976 cites W2006225923 @default.
- W4210927976 cites W2006443314 @default.
- W4210927976 cites W2006483299 @default.
- W4210927976 cites W2006594691 @default.
- W4210927976 cites W2012829798 @default.
- W4210927976 cites W2013008937 @default.
- W4210927976 cites W2019240520 @default.
- W4210927976 cites W2026999243 @default.
- W4210927976 cites W2029920851 @default.
- W4210927976 cites W2030303910 @default.
- W4210927976 cites W2032129221 @default.
- W4210927976 cites W2038156304 @default.
- W4210927976 cites W2042062103 @default.
- W4210927976 cites W2049055414 @default.
- W4210927976 cites W2052446799 @default.
- W4210927976 cites W2056030962 @default.
- W4210927976 cites W2059100663 @default.
- W4210927976 cites W2059909081 @default.
- W4210927976 cites W2060348125 @default.
- W4210927976 cites W2073059231 @default.
- W4210927976 cites W2084198349 @default.
- W4210927976 cites W2096423541 @default.
- W4210927976 cites W2098710248 @default.
- W4210927976 cites W2107253024 @default.
- W4210927976 cites W2119128096 @default.
- W4210927976 cites W2131072123 @default.
- W4210927976 cites W2139485998 @default.
- W4210927976 cites W2142018422 @default.
- W4210927976 cites W2144409714 @default.
- W4210927976 cites W2152055606 @default.
- W4210927976 cites W2170525321 @default.
- W4210927976 cites W2171560347 @default.
- W4210927976 cites W2300655373 @default.
- W4210927976 cites W2318474482 @default.
- W4210927976 cites W2319713839 @default.
- W4210927976 cites W2321941382 @default.
- W4210927976 cites W2328778894 @default.
- W4210927976 cites W2408452241 @default.
- W4210927976 cites W2474276388 @default.
- W4210927976 cites W2618072306 @default.
- W4210927976 cites W2737130296 @default.
- W4210927976 cites W2753915348 @default.
- W4210927976 cites W2769018611 @default.
- W4210927976 cites W2771431428 @default.
- W4210927976 cites W2786092482 @default.
- W4210927976 cites W2791722228 @default.
- W4210927976 cites W2799586630 @default.
- W4210927976 cites W2803080671 @default.
- W4210927976 cites W2807998637 @default.
- W4210927976 cites W2890458122 @default.
- W4210927976 cites W2896728718 @default.
- W4210927976 cites W2902554490 @default.
- W4210927976 cites W2903024684 @default.
- W4210927976 cites W2904420967 @default.
- W4210927976 cites W2913121738 @default.
- W4210927976 cites W2942044904 @default.
- W4210927976 cites W2963141353 @default.
- W4210927976 cites W2966289003 @default.
- W4210927976 cites W2982951748 @default.
- W4210927976 cites W2995617069 @default.
- W4210927976 cites W3011195687 @default.
- W4210927976 cites W3014959960 @default.
- W4210927976 cites W3030138290 @default.
- W4210927976 cites W3103600027 @default.
- W4210927976 cites W3126424583 @default.
- W4210927976 cites W3158678351 @default.
- W4210927976 cites W4211087439 @default.
- W4210927976 cites W4293872843 @default.
- W4210927976 cites W74691089 @default.
- W4210927976 doi "https://doi.org/10.1021/acsnano.1c10084" @default.
- W4210927976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35133785" @default.
- W4210927976 hasPublicationYear "2022" @default.
- W4210927976 type Work @default.