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- W4210930981 abstract "Background The diagnosis of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is challenging, and the role of Aspergillus-PCR in bronchoalveolar lavage (BAL) is unknown. Objectives This study evaluated diagnostic accuracy of Aspergillus-PCR in BAL in IPA in three different cohorts: ICU-admitted patients with COVID-19, ICU-admitted patients without COVID-19 and immunocompromised patients. Methods All stored available BAL samples collected from three patient groups were tested with Aspergillus-PCR (AsperGenius®). IPA was diagnosed according to appropriate criteria for each patient group. Results We included 111 BAL samples from 101 patients: 52 (51%) patients admitted to ICU for COVID-19, 24 (24%) admitted to ICU for other reasons and 25 (25%) immunocompromised. There were 31 cases of IPA (28%). Aspergillus-PCR sensitivity was 64% (95% CI 47–79) and specificity 99% (95% CI 93–100). Aspergillus-PCR sensitivity was 40% (95%CI 19–64) in ICU COVID-19, 67% (95% CI 21-93) in non-COVID-19 ICU patients and 92% (95%CI 67–98) in the immunocompromised. The concordance between positive BAL-GM and BAL-PCR in patients with and without IPA was significantly lower in ICU patients (32%; 43% in COVID-19, 18% in non-COVID-19) than in the immunocompromised (92%), p < .001. Conclusions Aspergillus-PCR in BAL improves the diagnostic accuracy of BAL-GM in ICU patients." @default.
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- W4210930981 date "2022-02-17" @default.
- W4210930981 modified "2023-09-30" @default.
- W4210930981 title "<i>Aspergillus</i> ‐PCR in bronchoalveolar lavage ‐ diagnostic accuracy for invasive pulmonary aspergillosis in critically ill patients" @default.
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- W4210930981 doi "https://doi.org/10.1111/myc.13428" @default.
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