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• W4210934239 endingPage "e0263744" @default.
• W4210934239 startingPage "e0263744" @default.
• W4210934239 abstract "Background Studies assessing normative values and sex differences in pulmonary function test parameters (PFTPs) among Indigenous populations are sparse. Methods PFTPs were compared between male and female Indigenous Australian adults with and without chest radiologically proven chronic airway diseases (CADs). Results 485 adults (56% were female) with no significant difference in age, body mass index or smoking status between sexes were included. Females displayed a higher prevalence of radiology without CADs compared to males (66 vs. 52%, respectively). Among patients without CADs, after adjustment for age, stature and smoking, males displayed significantly higher absolute values of Forced Vital Capacity (FVC) (mean difference, 0.41L (0.21,0.62), p<0.001) and Forced Expiratory Volume in one second (FEV 1 ) (mean difference 0.27L (0.07,0.47), p<0.001), with no significant difference in FEV 1 /FVC ratio (mean difference -0.02 (-0.06, 0.02), p = 0.174). Male and female patients with radiologically proven CADs demonstrated lower FEV 1 /FVC values. However, compared to females, males showed significantly greater reductions in pre- [-0.53 (-0.74, -0.32) vs. -0.29 (-0.42, -0.16), p = 0.045] and post- [-0.51 (-0.72, -0.3) vs. -0.27 (-0.39, -0.14), p = 0.049] bronchodilator FEV 1 . Conclusions There are significant sex differences in the PFTPs among Indigenous Australians. Recognising these differences may be of value in the accurate diagnosis, management, monitoring and prognostication of CADs in this population." @default.
• W4210934239 created "2022-02-09" @default.
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• W4210934239 date "2022-02-08" @default.
• W4210934239 modified "2023-09-25" @default.
• W4210934239 title "Sex differences in pulmonary function parameters among Indigenous Australians with and without chronic airway disease" @default.
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• W4210934239 doi "https://doi.org/10.1371/journal.pone.0263744" @default.
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