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• W4210935903 abstract "ABSTRACT Naturally fluctuating temperatures provide a constant environmental stress that requires adaptation. Some fungal pathogens respond to heat stress by producing new morphotypes that maximize their overall fitness. The fungal wheat pathogen Z. tritici responds to heat stress by switching from its yeast-like blastospore form to hyphae or chlamydospores. The regulatory mechanisms underlying this switch are unknown. Here, we demonstrate that a differential heat stress response is ubiquitous in Z. tritici populations around the world. We used QTL mapping to identify a single locus associated with the temperature-dependent morphogenesis and we found two genes, the transcription factor ZtMsr1 and the protein phosphatase ZtYvh1 , regulating this mechanism. We find that ZtMsr1 regulates repression of hyphal growth and induces chlamydospore formation whereas ZtYvh1 is required for hyphal growth. We next pinpointed that chlamydospore formation is a response to the intracellular osmotic stress generated by the heat stress. This intracellular stress stimulates the CWI and HOG MAPK pathways resulting in hyphal growth. If cell wall integrity is however compromised, ZtMsr1 represses the hyphal development program and might induce the chlamydospore-inducing genes as a stress-response survival strategy. Taken together, these results suggest a novel mechanism through which morphological transitions are orchestrated in Z. tritici – a mechanism possibly also present in other pleomorphic fungi. IMPORTANCE Temperature is an environmental signal constantly monitored by pleomorphic fungi. Our experiments showed that yeast-to-hyphal or yeast-to-chlamydospore transitions are ubiquitous heat stress responses in Z. tritici . QTL mapping allowed us to identify a transcription factor and a protein phosphatase contributing to temperature-dependent morphogenesis. We showed that intracellular osmolarity is the pivotal signal inducing these transitions. We propose a regulatory network controlling Z. tritici morphogenesis, which may have broad implications for temperature sensing of fungal pathogens." @default.
• W4210935903 created "2022-02-09" @default.
• W4210935903 creator A5017444708 @default.
• W4210935903 creator A5019962582 @default.
• W4210935903 creator A5056400720 @default.
• W4210935903 date "2022-02-08" @default.
• W4210935903 modified "2023-10-17" @default.
• W4210935903 title "A transcription factor and a phosphatase regulate temperature-dependent morphogenesis in a fungal plant pathogen" @default.
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• W4210935903 cites W1518340767 @default.
• W4210935903 cites W1588192538 @default.
• W4210935903 cites W1798315881 @default.
• W4210935903 cites W1906305764 @default.
• W4210935903 cites W1909542138 @default.
• W4210935903 cites W1957827495 @default.
• W4210935903 cites W1973041622 @default.
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• W4210935903 cites W1978945721 @default.
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• W4210935903 cites W1997437177 @default.
• W4210935903 cites W2001660017 @default.
• W4210935903 cites W2001876820 @default.
• W4210935903 cites W2006568893 @default.
• W4210935903 cites W2037777347 @default.
• W4210935903 cites W2040013747 @default.
• W4210935903 cites W2040518083 @default.
• W4210935903 cites W2043573783 @default.
• W4210935903 cites W2046967366 @default.
• W4210935903 cites W2050245762 @default.
• W4210935903 cites W2054040048 @default.
• W4210935903 cites W2060335717 @default.
• W4210935903 cites W2063713495 @default.
• W4210935903 cites W2064558289 @default.
• W4210935903 cites W2080492298 @default.
• W4210935903 cites W2083467590 @default.
• W4210935903 cites W2085741440 @default.
• W4210935903 cites W2085808820 @default.
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• W4210935903 cites W2112546055 @default.
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• W4210935903 cites W2121139063 @default.
• W4210935903 cites W2122798106 @default.
• W4210935903 cites W2124479692 @default.
• W4210935903 cites W2124610014 @default.
• W4210935903 cites W2125533723 @default.
• W4210935903 cites W2127290771 @default.
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• W4210935903 cites W2170964688 @default.
• W4210935903 cites W2171414364 @default.
• W4210935903 cites W2184532922 @default.
• W4210935903 cites W2228816633 @default.
• W4210935903 cites W2236319430 @default.
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• W4210935903 cites W2952904733 @default.
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• W4210935903 cites W4230096730 @default.
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• W4210935903 doi "https://doi.org/10.1101/2022.02.07.479299" @default.
• W4210935903 hasPublicationYear "2022" @default.
• W4210935903 type Work @default.
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• W4210935903 hasAuthorship W4210935903A5017444708 @default.
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