Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210947215> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4210947215 endingPage "6" @default.
- W4210947215 startingPage "1" @default.
- W4210947215 abstract "An 1194-nucleotide complementary DNA clone, FMI, encoding a human high-mobility group-I protein (HMG-I) was isolated from a well-differentiated human gastric-carcinoma cell line complementary DNA library by a differential screening method. FMI is similar to the published human HMG-I in mature protein, with only 3 different codons at positions 11, 149, and 190. We analyzed 33 gastric and colorectal adenocarcinomas for expression of the FMI gene. Northern-blot analysis revealed that all of the cancers expressed FMI at a higher level than in corresponding non-cancerous mucosa, with 2 transcripts of approximately 1.4 and 2.4 kilobases. The FMI expression level in the non-cancerous tissues increased with the depth of accompanying cancer invasion. Only 18.2% of well-differentiated cancers showed a higher expression level in corresponding non-cancerous tissues, whereas the expression in corresponding non-cancerous tissues was significantly higher in moderately (60%) and poorly differentiated (83.3%) cancers. In situ hybridization demonstrated the location of FMI mRNA in well- and poorly differentiated gastric-cancer cells as well as in non-cancerous tissue adjacent to poorly differentiated gastric cancer, but no hybridization was detected in normal epithelial cells adjacent to well-differentiated gastric cancer. These findings may provide new information on HMG-I mRNA expression in human gastrointestinal cancer and suggest a correlation between FMI mRNA expression to the differentiation and the stage of human gastrointestinal adenocarcinomas. Int. J. Cancer 74:1–6. © 1997 Wiley-Liss, Inc." @default.
- W4210947215 created "2022-02-09" @default.
- W4210947215 creator A5000601994 @default.
- W4210947215 creator A5004513459 @default.
- W4210947215 creator A5008194748 @default.
- W4210947215 creator A5010869375 @default.
- W4210947215 creator A5019744439 @default.
- W4210947215 creator A5032069454 @default.
- W4210947215 creator A5057851288 @default.
- W4210947215 creator A5074349263 @default.
- W4210947215 creator A5081577782 @default.
- W4210947215 date "1997-02-20" @default.
- W4210947215 modified "2023-09-25" @default.
- W4210947215 title "Expression of high‐mobility group‐1 mRNA in human gastrointestinal adenocarcinoma and corresponding non‐cancerous mucosa" @default.
- W4210947215 doi "https://doi.org/10.1002/(sici)1097-0215(19970220)74:1<1::aid-ijc1>3.3.co;2-a" @default.
- W4210947215 hasPublicationYear "1997" @default.
- W4210947215 type Work @default.
- W4210947215 citedByCount "0" @default.
- W4210947215 crossrefType "journal-article" @default.
- W4210947215 hasAuthorship W4210947215A5000601994 @default.
- W4210947215 hasAuthorship W4210947215A5004513459 @default.
- W4210947215 hasAuthorship W4210947215A5008194748 @default.
- W4210947215 hasAuthorship W4210947215A5010869375 @default.
- W4210947215 hasAuthorship W4210947215A5019744439 @default.
- W4210947215 hasAuthorship W4210947215A5032069454 @default.
- W4210947215 hasAuthorship W4210947215A5057851288 @default.
- W4210947215 hasAuthorship W4210947215A5074349263 @default.
- W4210947215 hasAuthorship W4210947215A5081577782 @default.
- W4210947215 hasConcept C104317684 @default.
- W4210947215 hasConcept C105580179 @default.
- W4210947215 hasConcept C121608353 @default.
- W4210947215 hasConcept C142724271 @default.
- W4210947215 hasConcept C2781182431 @default.
- W4210947215 hasConcept C502942594 @default.
- W4210947215 hasConcept C54355233 @default.
- W4210947215 hasConcept C71924100 @default.
- W4210947215 hasConcept C81439078 @default.
- W4210947215 hasConcept C86803240 @default.
- W4210947215 hasConcept C96232424 @default.
- W4210947215 hasConceptScore W4210947215C104317684 @default.
- W4210947215 hasConceptScore W4210947215C105580179 @default.
- W4210947215 hasConceptScore W4210947215C121608353 @default.
- W4210947215 hasConceptScore W4210947215C142724271 @default.
- W4210947215 hasConceptScore W4210947215C2781182431 @default.
- W4210947215 hasConceptScore W4210947215C502942594 @default.
- W4210947215 hasConceptScore W4210947215C54355233 @default.
- W4210947215 hasConceptScore W4210947215C71924100 @default.
- W4210947215 hasConceptScore W4210947215C81439078 @default.
- W4210947215 hasConceptScore W4210947215C86803240 @default.
- W4210947215 hasConceptScore W4210947215C96232424 @default.
- W4210947215 hasIssue "1" @default.
- W4210947215 hasLocation W42109472151 @default.
- W4210947215 hasOpenAccess W4210947215 @default.
- W4210947215 hasPrimaryLocation W42109472151 @default.
- W4210947215 hasRelatedWork W2339808165 @default.
- W4210947215 hasRelatedWork W2344637265 @default.
- W4210947215 hasRelatedWork W2378785636 @default.
- W4210947215 hasRelatedWork W2391924536 @default.
- W4210947215 hasRelatedWork W2783732652 @default.
- W4210947215 hasRelatedWork W2974647127 @default.
- W4210947215 hasRelatedWork W2996890875 @default.
- W4210947215 hasRelatedWork W3049178086 @default.
- W4210947215 hasRelatedWork W3208750523 @default.
- W4210947215 hasRelatedWork W3215939181 @default.
- W4210947215 hasVolume "74" @default.
- W4210947215 isParatext "false" @default.
- W4210947215 isRetracted "false" @default.
- W4210947215 workType "article" @default.