Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210947403> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4210947403 endingPage "viii" @default.
- W4210947403 startingPage "vii" @default.
- W4210947403 abstract "Most nucleoside-derived anticancer drugs are taken up by the high-affinity Na-dependent nucleoside transporter CNT1. Since such drugs are to some extent cell-cycle-dependent in their cytotoxic action, we examined the relationship between CNT1 expression and cell-cycle progression in the rat hepatoma cell line FAO. Cell cultures were synchronized either at late G1 or early S stages by combining mimosin treatment with either previous synchronization or not by serum starvation. Cell-cycle progression was then assessed by measuring [methyl-3H]thymidine incorporation into DNA and monitoring cyclin E and A protein levels. In these conditions, CNT1 protein amounts increase at the G1–S transition. When cells were synchronized using hydroxyurea (HU), which directly interacts with nucleotide metabolism by inhibiting ribonucleotide reductase, CNT1 protein amounts increased in synchronized cells and remained high during cell-cycle progression. These data indicate that CNT1 adapts to cell-cycle progression and responds to nucleos(t)ide metabolism status, a feature that might contribute to the cytotoxic action of cell-cycle-dependent anticancer drugs." @default.
- W4210947403 created "2022-02-09" @default.
- W4210947403 date "2003-02-01" @default.
- W4210947403 modified "2023-09-25" @default.
- W4210947403 title "Author Index" @default.
- W4210947403 doi "https://doi.org/10.1016/s0006-291x(03)00036-6" @default.
- W4210947403 hasPublicationYear "2003" @default.
- W4210947403 type Work @default.
- W4210947403 citedByCount "0" @default.
- W4210947403 crossrefType "journal-article" @default.
- W4210947403 hasConcept C104292427 @default.
- W4210947403 hasConcept C104317684 @default.
- W4210947403 hasConcept C149011108 @default.
- W4210947403 hasConcept C1491633281 @default.
- W4210947403 hasConcept C153911025 @default.
- W4210947403 hasConcept C154317977 @default.
- W4210947403 hasConcept C202751555 @default.
- W4210947403 hasConcept C2776543447 @default.
- W4210947403 hasConcept C2777108182 @default.
- W4210947403 hasConcept C2780549722 @default.
- W4210947403 hasConcept C29537977 @default.
- W4210947403 hasConcept C4710235 @default.
- W4210947403 hasConcept C512185932 @default.
- W4210947403 hasConcept C54355233 @default.
- W4210947403 hasConcept C552990157 @default.
- W4210947403 hasConcept C55493867 @default.
- W4210947403 hasConcept C62112901 @default.
- W4210947403 hasConcept C81885089 @default.
- W4210947403 hasConcept C86803240 @default.
- W4210947403 hasConcept C95444343 @default.
- W4210947403 hasConcept C98892162 @default.
- W4210947403 hasConceptScore W4210947403C104292427 @default.
- W4210947403 hasConceptScore W4210947403C104317684 @default.
- W4210947403 hasConceptScore W4210947403C149011108 @default.
- W4210947403 hasConceptScore W4210947403C1491633281 @default.
- W4210947403 hasConceptScore W4210947403C153911025 @default.
- W4210947403 hasConceptScore W4210947403C154317977 @default.
- W4210947403 hasConceptScore W4210947403C202751555 @default.
- W4210947403 hasConceptScore W4210947403C2776543447 @default.
- W4210947403 hasConceptScore W4210947403C2777108182 @default.
- W4210947403 hasConceptScore W4210947403C2780549722 @default.
- W4210947403 hasConceptScore W4210947403C29537977 @default.
- W4210947403 hasConceptScore W4210947403C4710235 @default.
- W4210947403 hasConceptScore W4210947403C512185932 @default.
- W4210947403 hasConceptScore W4210947403C54355233 @default.
- W4210947403 hasConceptScore W4210947403C552990157 @default.
- W4210947403 hasConceptScore W4210947403C55493867 @default.
- W4210947403 hasConceptScore W4210947403C62112901 @default.
- W4210947403 hasConceptScore W4210947403C81885089 @default.
- W4210947403 hasConceptScore W4210947403C86803240 @default.
- W4210947403 hasConceptScore W4210947403C95444343 @default.
- W4210947403 hasConceptScore W4210947403C98892162 @default.
- W4210947403 hasIssue "2" @default.
- W4210947403 hasLocation W42109474031 @default.
- W4210947403 hasOpenAccess W4210947403 @default.
- W4210947403 hasPrimaryLocation W42109474031 @default.
- W4210947403 hasRelatedWork W1977468279 @default.
- W4210947403 hasRelatedWork W2012209901 @default.
- W4210947403 hasRelatedWork W2042118988 @default.
- W4210947403 hasRelatedWork W2055366578 @default.
- W4210947403 hasRelatedWork W2066519212 @default.
- W4210947403 hasRelatedWork W2072481810 @default.
- W4210947403 hasRelatedWork W2363880822 @default.
- W4210947403 hasRelatedWork W2373495330 @default.
- W4210947403 hasRelatedWork W2374592133 @default.
- W4210947403 hasRelatedWork W2387175565 @default.
- W4210947403 hasVolume "301" @default.
- W4210947403 isParatext "false" @default.
- W4210947403 isRetracted "false" @default.
- W4210947403 workType "article" @default.