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- W4210947479 abstract "Functionalization of nanocarriers has been considered the most promising way of ensuring an accurate and targeted drug delivery system. This study reports the synthesis of bifunctional folic-conjugated aspartic-modified Fe3O4 nanocarriers with an excellent ability to deliver doxorubicin (DOX), an anticancer drug, into the intercellular matrix. Here, the presence of amine and carboxylate groups enables aspartic acid (AA) to be used as an efficient anchoring molecule for the conjugation of folic acid (FA) (EDC-NHS coupling) and DOX (electrostatic interaction). Based on the results, surface functionalization showed little effect on the physicochemical properties of the nanoparticles but significantly influenced both the loading and release efficiency of DOX. This is primarily caused by the steric hindrance effect due to large and bulky FA molecules. Furthermore, in vitro MTT assay of B16-F1 cell lines revealed that FA conjugation was responsible for a significant increase in the cytotoxicity of DOX-loaded nanocarriers, which was also found to be proportional to AA concentration. This high cytotoxicity resulted from an efficient cellular uptake induced by the over-expressed folate receptors and fast pH triggered DOX release inside the target cell. Here, the lowest IC50 value of DOX-loaded nanocarriers was achieved at 2.814 ± 0.449 μg mL-1. Besides, further investigation also showed that the drug-loaded nanocarriers exhibited less or no toxicity against normal cells." @default.
- W4210947479 created "2022-02-09" @default.
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- W4210947479 date "2022-01-01" @default.
- W4210947479 modified "2023-10-17" @default.
- W4210947479 title "Bifunctional folic-conjugated aspartic-modified Fe<sub>3</sub>O<sub>4</sub> nanocarriers for efficient targeted anticancer drug delivery" @default.
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- W4210947479 doi "https://doi.org/10.1039/d1ra08776b" @default.
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