FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210947743> ?p ?o ?g. }

• W4210947743 abstract "Background: Fibronectin ( FN1 ) is an essential regulator of homodynamic processes and tissue remodeling that have been proposed to contribute to atherosclerosis. Moreover, recent large-scale genome-wide association studies (GWAS) have linked common genetic variants within the FN1 gene to coronary artery disease risk. Methods: Public databases were analyzed by 2-Sample Mendelian Randomization. Expression constructs encoding short FN1 reporter constructs and full-length plasma FN1 variants were introduced in various cell models. Secreted and cellular levels were then analyzed and quantified by SDS-PAGE and fluorescence microscopy. Mass spectrometry and glycosylation analyses were performed to probe possible posttranscriptional differences. Results: Bioinformatic analyses revealed that common coronary artery disease risk single nucleotide polymorphisms in the FN1 locus associate with circulating levels of FN1 and that higher FN1 (fibronectin 1) protein levels in plasma are linked to lower coronary artery disease risk. The coronary artery disease-associated FN1 locus encompasses a common polymorphism that translates a L15Q variant situated within the FN1 signal peptide. Introduction of FN1 reporter constructs, differing at position 15, revealed differences in secretion, with the FN1 Q15 variant being less well secreted. Moreover, the L15Q polymorphism was found to alter glycosylation in some cell models but not in human plasma. Conclusions: In addition to providing novel functional evidence implicating FN1 in cardioprotection, these findings demonstrate that a common variant within a secretion signal peptide regulates protein function." @default.
• W4210947743 created "2022-02-09" @default.
• W4210947743 creator A5007653975 @default.
• W4210947743 creator A5010879940 @default.
• W4210947743 creator A5041031002 @default.
• W4210947743 creator A5062724268 @default.
• W4210947743 creator A5089497908 @default.
• W4210947743 date "2022-04-01" @default.
• W4210947743 modified "2023-10-18" @default.
• W4210947743 title "Common Polymorphism That Protects From Cardiovascular Disease Increases Fibronectin Processing and Secretion" @default.
• W4210947743 cites W1563015144 @default.
• W4210947743 cites W1602678826 @default.
• W4210947743 cites W1743894323 @default.
• W4210947743 cites W1887076575 @default.
• W4210947743 cites W1966526938 @default.
• W4210947743 cites W1991366673 @default.
• W4210947743 cites W2018355418 @default.
• W4210947743 cites W2019983262 @default.
• W4210947743 cites W2073614919 @default.
• W4210947743 cites W2089621623 @default.
• W4210947743 cites W2092731808 @default.
• W4210947743 cites W2097792029 @default.
• W4210947743 cites W2099560426 @default.
• W4210947743 cites W2106203560 @default.
• W4210947743 cites W2108614024 @default.
• W4210947743 cites W2111005494 @default.
• W4210947743 cites W2134839779 @default.
• W4210947743 cites W2150215679 @default.
• W4210947743 cites W2156714600 @default.
• W4210947743 cites W2164531600 @default.
• W4210947743 cites W2165619954 @default.
• W4210947743 cites W2277439059 @default.
• W4210947743 cites W2398690791 @default.
• W4210947743 cites W2522716802 @default.
• W4210947743 cites W2566116513 @default.
• W4210947743 cites W2581452190 @default.
• W4210947743 cites W2612591211 @default.
• W4210947743 cites W2735404270 @default.
• W4210947743 cites W2739458618 @default.
• W4210947743 cites W2775393828 @default.
• W4210947743 cites W2806225217 @default.
• W4210947743 cites W2883517933 @default.
• W4210947743 cites W2885870007 @default.
• W4210947743 cites W2889776411 @default.
• W4210947743 cites W2899140256 @default.
• W4210947743 cites W2912733745 @default.
• W4210947743 cites W2949543964 @default.
• W4210947743 cites W2952835495 @default.
• W4210947743 cites W2966217839 @default.
• W4210947743 cites W2969915148 @default.
• W4210947743 cites W3214679739 @default.
• W4210947743 doi "https://doi.org/10.1161/circgen.121.003428" @default.
• W4210947743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35130031" @default.
• W4210947743 hasPublicationYear "2022" @default.
• W4210947743 type Work @default.
• W4210947743 citedByCount "4" @default.
• W4210947743 countsByYear W42109477432022 @default.
• W4210947743 countsByYear W42109477432023 @default.
• W4210947743 crossrefType "journal-article" @default.
• W4210947743 hasAuthorship W4210947743A5007653975 @default.
• W4210947743 hasAuthorship W4210947743A5010879940 @default.
• W4210947743 hasAuthorship W4210947743A5041031002 @default.
• W4210947743 hasAuthorship W4210947743A5062724268 @default.
• W4210947743 hasAuthorship W4210947743A5089497908 @default.
• W4210947743 hasBestOaLocation W42109477431 @default.
• W4210947743 hasConcept C104317684 @default.
• W4210947743 hasConcept C126322002 @default.
• W4210947743 hasConcept C134018914 @default.
• W4210947743 hasConcept C135763542 @default.
• W4210947743 hasConcept C1491633281 @default.
• W4210947743 hasConcept C153209595 @default.
• W4210947743 hasConcept C2778213512 @default.
• W4210947743 hasConcept C2779901538 @default.
• W4210947743 hasConcept C2993967602 @default.
• W4210947743 hasConcept C54355233 @default.
• W4210947743 hasConcept C60644358 @default.
• W4210947743 hasConcept C71924100 @default.
• W4210947743 hasConcept C84597430 @default.
• W4210947743 hasConcept C86492073 @default.
• W4210947743 hasConcept C86803240 @default.
• W4210947743 hasConceptScore W4210947743C104317684 @default.
• W4210947743 hasConceptScore W4210947743C126322002 @default.
• W4210947743 hasConceptScore W4210947743C134018914 @default.
• W4210947743 hasConceptScore W4210947743C135763542 @default.
• W4210947743 hasConceptScore W4210947743C1491633281 @default.
• W4210947743 hasConceptScore W4210947743C153209595 @default.
• W4210947743 hasConceptScore W4210947743C2778213512 @default.
• W4210947743 hasConceptScore W4210947743C2779901538 @default.
• W4210947743 hasConceptScore W4210947743C2993967602 @default.
• W4210947743 hasConceptScore W4210947743C54355233 @default.
• W4210947743 hasConceptScore W4210947743C60644358 @default.
• W4210947743 hasConceptScore W4210947743C71924100 @default.
• W4210947743 hasConceptScore W4210947743C84597430 @default.
• W4210947743 hasConceptScore W4210947743C86492073 @default.
• W4210947743 hasConceptScore W4210947743C86803240 @default.
• W4210947743 hasIssue "2" @default.
• W4210947743 hasLocation W42109477431 @default.
• W4210947743 hasLocation W42109477432 @default.
• W4210947743 hasLocation W42109477433 @default.
• W4210947743 hasOpenAccess W4210947743 @default.

• next