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• W4210954290 startingPage "1079" @default.
• W4210954290 abstract "Activated T cells drive the initiation and progression of a number of inflammatory diseases following their recognition of autoantigen or allergen. These activated T cells, including TH1, TH2, and TH17 cells, support B cell activation and autoantibody production and produce a wide array of cytokines, chemokines, and growth factors which promote further T cell activation, including cytotoxic T cells that cause direct tissue damage, and attract and activate other leukocytes and nonhaematopoietic cells, serving to amplify the inflammatory response. A number of T cell-targeting monoclonal antibody (mAbs) are in early clinical trials in organ transplantation and associated graft-versus-host disease (GvHD), rheumatoid arthritis (RA), psoriasis, multiple sclerosis (MS), systemic lupus erythematosis (SLE), inflammatory bowel disease (IBD), and asthma. These are designed to directly deplete or modulate the function of T cells by targeting either the T cell receptor (TCR) complex, including the TCR itself or CD3, the T cell activation-associated accessory molecule CD4, or a range of co-stimulatory molecules that promote T cell activation." @default.
• W4210954290 created "2022-02-13" @default.
• W4210954290 creator A5031461430 @default.
• W4210954290 date "2014-08-12" @default.
• W4210954290 modified "2023-10-17" @default.
• W4210954290 title "T Cell Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders" @default.
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