Matches in SemOpenAlex for { <https://semopenalex.org/work/W4210957268> ?p ?o ?g. }
- W4210957268 endingPage "162" @default.
- W4210957268 startingPage "162" @default.
- W4210957268 abstract "Due to organ shortage and rising life expectancy the age of organ donors and recipients is increasing. Reliable biomarkers of organ quality that predict successful long-term transplantation outcomes are poorly defined. The aim of this study was the identification of age-related markers of kidney function that might accurately reflect donor organ quality. Histomorphometric, biochemical and molecular parameters were measured in young (3-month-old) and old (24-month-old) male Sprague Dawley rats. In addition to conventional methods, we used urine metabolomics by NMR spectroscopy and gene expression analysis by quantitative RT-PCR to identify markers of ageing relevant to allograft survival. Beside known markers of kidney ageing like albuminuria, changes in the concentration of urine metabolites such as trimethylamine-N-oxide, trigonelline, 2-oxoglutarate, citrate, hippurate, glutamine, acetoacetate, valine and 1-methyl-histidine were identified in association with ageing. In addition, expression of several genes of the toll-like receptor (TLR) pathway, known for their implication in inflammaging, were upregulated in the kidneys of old rats. This study led to the identification of age-related markers of biological allograft age potentially relevant for allograft survival in the future. Among those, urine metabolites and markers of immunity and inflammation, which are highly relevant to immunosuppression in transplant recipients, are promising and deserve further investigation in humans." @default.
- W4210957268 created "2022-02-13" @default.
- W4210957268 creator A5002628989 @default.
- W4210957268 creator A5009502558 @default.
- W4210957268 creator A5010970457 @default.
- W4210957268 creator A5025358800 @default.
- W4210957268 creator A5027976807 @default.
- W4210957268 creator A5032457146 @default.
- W4210957268 creator A5037470013 @default.
- W4210957268 creator A5049091055 @default.
- W4210957268 creator A5052319857 @default.
- W4210957268 creator A5064176373 @default.
- W4210957268 creator A5081132382 @default.
- W4210957268 creator A5081742830 @default.
- W4210957268 date "2022-02-08" @default.
- W4210957268 modified "2023-09-25" @default.
- W4210957268 title "Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation" @default.
- W4210957268 cites W1870586278 @default.
- W4210957268 cites W1894543987 @default.
- W4210957268 cites W1966822395 @default.
- W4210957268 cites W1969753425 @default.
- W4210957268 cites W1972084827 @default.
- W4210957268 cites W1981621132 @default.
- W4210957268 cites W1984990753 @default.
- W4210957268 cites W1997295514 @default.
- W4210957268 cites W1998609229 @default.
- W4210957268 cites W2009291602 @default.
- W4210957268 cites W2021050906 @default.
- W4210957268 cites W2044812260 @default.
- W4210957268 cites W2044999311 @default.
- W4210957268 cites W2048657237 @default.
- W4210957268 cites W2054737428 @default.
- W4210957268 cites W2056729526 @default.
- W4210957268 cites W2056910294 @default.
- W4210957268 cites W2073798353 @default.
- W4210957268 cites W2077684987 @default.
- W4210957268 cites W2082402714 @default.
- W4210957268 cites W2083113920 @default.
- W4210957268 cites W2100757193 @default.
- W4210957268 cites W2101624429 @default.
- W4210957268 cites W2108196440 @default.
- W4210957268 cites W2110065044 @default.
- W4210957268 cites W2113835200 @default.
- W4210957268 cites W2116911322 @default.
- W4210957268 cites W2126677023 @default.
- W4210957268 cites W2129454878 @default.
- W4210957268 cites W2137746278 @default.
- W4210957268 cites W2142288396 @default.
- W4210957268 cites W2156009645 @default.
- W4210957268 cites W2170999650 @default.
- W4210957268 cites W2197510689 @default.
- W4210957268 cites W2231590221 @default.
- W4210957268 cites W2400000792 @default.
- W4210957268 cites W2410374774 @default.
- W4210957268 cites W2462347288 @default.
- W4210957268 cites W2808943201 @default.
- W4210957268 cites W2961784779 @default.
- W4210957268 cites W3005747003 @default.
- W4210957268 cites W3019948503 @default.
- W4210957268 cites W3024763324 @default.
- W4210957268 cites W75552241 @default.
- W4210957268 cites W78647631 @default.
- W4210957268 doi "https://doi.org/10.3390/metabo12020162" @default.
- W4210957268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35208236" @default.
- W4210957268 hasPublicationYear "2022" @default.
- W4210957268 type Work @default.
- W4210957268 citedByCount "0" @default.
- W4210957268 crossrefType "journal-article" @default.
- W4210957268 hasAuthorship W4210957268A5002628989 @default.
- W4210957268 hasAuthorship W4210957268A5009502558 @default.
- W4210957268 hasAuthorship W4210957268A5010970457 @default.
- W4210957268 hasAuthorship W4210957268A5025358800 @default.
- W4210957268 hasAuthorship W4210957268A5027976807 @default.
- W4210957268 hasAuthorship W4210957268A5032457146 @default.
- W4210957268 hasAuthorship W4210957268A5037470013 @default.
- W4210957268 hasAuthorship W4210957268A5049091055 @default.
- W4210957268 hasAuthorship W4210957268A5052319857 @default.
- W4210957268 hasAuthorship W4210957268A5064176373 @default.
- W4210957268 hasAuthorship W4210957268A5081132382 @default.
- W4210957268 hasAuthorship W4210957268A5081742830 @default.
- W4210957268 hasBestOaLocation W42109572681 @default.
- W4210957268 hasConcept C126322002 @default.
- W4210957268 hasConcept C21565614 @default.
- W4210957268 hasConcept C2779349466 @default.
- W4210957268 hasConcept C2780026642 @default.
- W4210957268 hasConcept C2780091579 @default.
- W4210957268 hasConcept C2911091166 @default.
- W4210957268 hasConcept C42407357 @default.
- W4210957268 hasConcept C500499127 @default.
- W4210957268 hasConcept C515207424 @default.
- W4210957268 hasConcept C55493867 @default.
- W4210957268 hasConcept C60644358 @default.
- W4210957268 hasConcept C71924100 @default.
- W4210957268 hasConcept C86803240 @default.
- W4210957268 hasConcept C9832595 @default.
- W4210957268 hasConceptScore W4210957268C126322002 @default.
- W4210957268 hasConceptScore W4210957268C21565614 @default.
- W4210957268 hasConceptScore W4210957268C2779349466 @default.